Perfusion CT in cirrhotic patients with early stage hepatocellular carcinoma: Assessment of tumor-related vascularization

European Journal of Radiology

Volumn 73, Issue 1, 2010, Pages 148-152

  Ippolito, Davide ^a,b   Sironi, Sandro ^a,b   Pozzi, Massimo ^a,b   Antolini, Laura ^a,c   Invernizzi, Francesca ^a,b   Ratti, Laura ^a,b   Leone, Eugenio Biagio ^a,b   Fazio, Ferruccio ^a,d,e  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b H SGerardo Monza ^*  (Italy)

^c Section of Medical Statistics   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

^e INSTITUTE OF MOLECULAR BIOIMAGING AND PHYSIOLOGY   (Italy)

Author keywords

CT perfusion; Functional computed tomography; Hepatocellular carcinoma

Indexed keywords

BLOOD VOLUMES; FUNCTIONAL COMPUTED TOMOGRAPHY; HEPATOCELLULAR CARCINOMA; LIVER CIRRHOSIS; MULTIDETECTOR COMPUTED TOMOGRAPHY; QUANTITATIVE DATA; QUANTITATIVE INFORMATION; STATISTICAL ANALYSIS; TIME TO PEAK; UNIVARIATE; VASCULARIZATION; WILCOXON SIGNED RANK TEST;

LIVER; TUMORS;

COMPUTERIZED TOMOGRAPHY;

IODINATED CONTRAST MEDIUM;

ADULT; AGED; ARTERY PERFUSION; ARTICLE; BLOOD VOLUME; CLINICAL ARTICLE; FEMALE; HUMAN; IMAGING SYSTEM; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER PERFUSION; MALE; PERFUSION WEIGHTED IMAGING; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION; TUMOR GROWTH; TUMOR VASCULARIZATION;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; FEMALE; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; PERFUSION IMAGING; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 73449107726     PISSN: 0720048X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejrad.2008.10.014     Document Type: Article

References (19)

1. Van Beers B.E., Leconte I., Materne R., et al. Hepatic perfusion parameters in chronic liver disease: dynamic CT measurements correlated with disease severity. AJR Am J Roentgenol 176 (2001) 667-673
2. Tsushima Y., Blomley M.J., Kusano S., et al. The portal component of hepatic perfusion measured by dynamic CT: an indicator of hepatic parenchymal damage. Dig Dis Sci 44 (1999) 1632-1638
3. Pandharipande P.V., Krinsky G.A., Rusinek H., et al. Perfusion imaging of the liver: current challenges and future goals. Radiology 234 (2005) 661-673
4. Park Y.N., Yang C.P., Fernandez G.J., et al. Neoangio-genesis and sinusoidal capillarization in dysplastic nodules of the liver. Am J Surg Pathol 22 (1998) 656-662
5. Pluda J.M. Tumor-associated angiogenesis: mechanisms, clinical applications and therapeutic strategies. Semin Oncol 24 (1997) 203-218
6. Sahani D.V., Holalkere N.S., Mueller P.R., et al. Advanced hepatocellular carcinoma: CT perfusion of liver and tumor tissue-initial experience. Radiology 243 (2007) 736-743
7. Miles K.A., Hayball M., and Dixon A.K. Colour perfusion imaging: a new application of computed tomography. Lancet 337 (1991) 643-645
8. Miles K.A., Leggett D.A.C., Kelley B.B., et al. In vivo assessment of neovascularization of liver metastases using perfusion CT. Br J Radiol 71 (1998) 276-281
9. Miles K.A., Charnsangavej C., Lee F.T., et al. Application of CT in the investigation of angiogenesis in oncology. Acad Radiol 7 (2000) 840-850
10. Miles K.A., and Griffiths M.R. Perfusion CT: a worthwhile enhancement?. Br J Radiol 76 (2003) 220-231
11. Miles K.A. Perfusion CT for the assessment of tumour vascularity: which protocol?. Br J Radiol 76 (2003) 36-42
12. Miles K.A., Hayball M.P., and Dixon A.K. Functional images of hepatic perfusion obtained with dynamic CT. Radiology 188 (1993) 405-411
13. Bruix J., Sherman M., Llovet J.M., et al. Clinical management of hepatocellular carcinoma: conclusions of the Barcelona-2000 EASL conference. J Hepatol 35 (2001) 421-430
14. Bruix J., and Sherman M. Management of hepatocellular carcinoma. Hepatology 42 (2005) 337-356
15. Fournier L.S., Cuenod C.A., de Bazelaire C., et al. Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent. Eur Radiol 14 (2004) 2125-2133
16. Wanless I.R. Nodular regenerative hyperplasia, dysplasia, and hepatocellular carcinoma. Am J Gastroenterol 91 (1996) 836-837
17. Hayashi M., Matsui O., Ueda K., et al. Correlation between the blood supply and grade of malignancy of hepatocellular nodules associated with liver cirrhosis: evaluation by CT during intra-arterial injection of contrast medium. AJR Am J Roentgenol 172 (1999) 969-976
18. Kim C.K., Lim J.H., Park C.K., et al. Neoangiogenesis and sinusoidal capillarization in hepatocellular carcinoma: correlation between dynamic CT and density of tumor microvessels. Radiology 237 (2005) 529-534
19. Tsushima Y., Fubasama S., Aoki J., et al. Quantitative perfusion map of malignant liver tumors, created from dynamic computed tomography data. Acad Radiol 11 (2004) 215-223