Perfusion CT: A worthwhile enhancement?

British Journal of Radiology

Volumn 76, Issue 904, 2003, Pages 220-231

  Miles, K A ^a,b   Griffiths, M R ^a,b  

^a WESLEY HOSPITAL   (Australia)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; FIBRINOLYTIC AGENT; IODINATED CONTRAST MEDIUM; TRACER;

ARTERY BLOOD FLOW; BIOMEDICAL TECHNOLOGY ASSESSMENT; BRAIN PERFUSION; CANCER; CANCER DIAGNOSIS; CANCER GRADING; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; COMPUTER PROGRAM; CONTRAST ENHANCEMENT; COST BENEFIT ANALYSIS; DRUG MONITORING; DRUG RESPONSE; HEALTH CARE COST; HUMAN; IMAGE ANALYSIS; IMAGE ENHANCEMENT; IMAGE PROCESSING; IMAGE QUALITY; IMAGING SYSTEM; PERFUSION COMPUTER ASSISTED TOMOGRAPHY; PROGNOSIS; RADIOLOGICAL PARAMETERS; REPRODUCIBILITY; REVIEW; STROKE; TISSUE PERFUSION; VALIDATION PROCESS;

CEREBROVASCULAR ACCIDENT; CONTRAST MEDIA; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PERFUSION; REPRODUCIBILITY OF RESULTS; SOFTWARE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0037650168     PISSN: 00071285     EISSN: None     Source Type: Journal    
DOI: 10.1259/bjr/13564625     Document Type: Review

References (85)

1. Axel L. Cerebral blood flow determination by rapid-sequence computed tomography: Theoretical analysis. Radiology 1980;137:679-86.
2. Wolfkiel CJ, Ferguson JL, Chomka EV, Law WR, Labin IN, Tenzer ML, et al. Measurement of myocardial blood flow by ultrafast computed tomography. Circulation 1987;76:1262-73.
3. Jaschke W, Sievers RS, Lipton MJ, Cogan MG. Cine-computed tomographic assessment of regional renal blood flow. Acta Radiol 1990;31:77-81.
4. Miles KA, Hayball M, Dixon AK. Colour perfusion imaging: A new application of computed tomography. Lancet 1991;337:643-5.
5. Miles KA, Hayball MP, Dixon AK. Functional images of hepatic perfusion obtained with dynamic CT. Radiology 1993;188:405-11.
6. Miles KA, Griffiths MR, Fuentes MA. Standardized perfusion value: Universal CT contrast enhancement scale that correlates with FDG PET in lung nodules. Radiology 2001;220:548-53.
7. Keith C, Griffiths M, Petersen B, Anderson R, Miles K. Computed tomography perfusion imaging in acute stroke. Australas Radiol 2002;46:221-30.
8. Mullani N, Herbst R, Abbruzzese J, Charnsangavej C, Kim E, Tran H, et al. Antiangiogenic treatment with endostatin results in uncoupling of blood flow and glucose metabolism in human tumors. Clin Positron Imaging 2000;3:151.
9. Maxwell RJ, Wilson J, Prise VE, Vojnovic B, Rustin GJ, Lodge MA, et al. Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI. NMR Biomed 2002;15:89-98.
10. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rtPA Stroke Study Group. N Engl J Med 1995;333:1581-7.
11. Hacke W, Kaste M, Fieschi C, Von Kummer R, Davalos A, Meier D, et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet 1998;352:1245-51.
12. Koenig M, Kraus M, Theek C, Klotz E, Gehlen W, Heuser L. Quantitative assessment of the ischemic brain by means of perfusion-related parameters derived from perfusion CT. Stroke 2001;32:431-7.
13. Mayer TE, Hamann GF, Baranczyk J, Rosengarten B, Klotz E, Wiesmann M, et al. Dynamic CT perfusion imaging of acute stroke. Am J Neuroradiol 2000;21:1441-9.
14. Klotz E, König M. Perfusion measurements of the brain: Using dynamic CT for the quantitative assessment of cerebral ischemia in acute stroke. Eur J Radiol 1999;30:170-84.
15. Wintermark M, Reichhart M, Thiran JP, Maeder P, Chalaron M, Schnyder P, et al. Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients. Ann Neurol 2002;51:417-32.
16. Brawer MK, Deering RE, Brown M, Preston SD, Bigler SA. Predictors of pathologic stage in prostatic carcinoma. The role of neovascularity. Cancer 1994;73:678-87.
17. Fontanini G, Lucchi M, Vignati S, Mussi A, Ciardiello F, De Laurentiis M, et al. Angiogenesis as a prognostic indicator of survival in non-small cell lung carcinoma: A prospective study. J Natl Cancer Inst 1997;89:881-6.
18. Miles KA, Charnsangavej C, Lee FT, Fishman EK, Horton K, Lee TY. Application of CT in the investigation of angiogenesis in oncology. Acad Radiol 2000;7:840-50.
19. Swensen SJ, Brown LR, Colby TV, Weaver AL, Midthun DE. Lung nodule enhancement at CT: Prospective findings. Radiology 1996;201:447-55.
20. Tateishi U, Nishihara H, Watanabe S, Morikawa T, Abe K, Miyasaka K. Tumor angiogenesis and dynamic CT in lung adenocarcinoma: Radiologic-pathologic correlation. J Comput Assist Tomogr 2001;25:23-7.
21. Jinzaki M, Tanimoto A, Mukai M, Ikeda E, Kobayashi S, Yuasa Y, et al. Double-phase helical CT of small renal parenchymal neoplasms: Correlation with pathologic findings and tumor angiogenesis. J Comput Assist Tomogr 2000;24:835-42.
22. Miles KA. Tumour angiogenesis and its relation to contrast enhancement of computed tomography: A review. Eur J Radiol 1999;30:198-205.
23. Swensen SJ, Viggiano RW, Midthun DE, Muller NL, Sherrick A, Yamashita K, et al. Lung nodule enhancement at CT: Multicenter study. Radiology 2000;214:73-80.
24. Zhang M, Kono M. Solitary pulmonary nodules: Evaluation of blood flow patterns with dynamic CT. Radiology 1997;205:471-8.
25. Fukuya T, Honda H, Hayashi T, Kaneko K, Tateshi Y, Ro T, et al. Lymph-node metastases: Efficacy for detection with helical CT in patients with gastric cancer. Radiology 1995;197:705-11.
26. Cuenod C, Leconte I, Siauve N, Resten A, Dromain C, Poulet B, et al. Early changes in liver perfusion caused by occult metastases in rats: Detection with quantitative CT. Radiology 2001;218:556-61.
27. Platt JF, Francis IR, Ellis JH, Reige KA. Liver metastases: Early detection based on abnormal contrast material enhancement at dual-phase helical CT. Radiology 1997;205:49-53.
28. Sheafor DH, Killius JS, Paulson EK, DeLong DM, Foti AM, Nelson RC. Hepatic parenchymal enhancement during triplet-phase helical CT: Can it be used to predict which patients with breast cancer will develop hepatic metastases? Radiology 2000;214:875-80.
29. Leggett DA, Kelley BB, Bunce IH, Miles KA. Colorectal cancer: Diagnostic potential of CT measurements of hepatic perfusion and implications for contrast enhancement protocols. Radiology 1997;205:716-20.
30. Dugdale PE, Miles KA. Hepatic metastases: The value of quantitative assessment of contrast enhancement on computed tomography. Eur J Radiol 1999;30:206-13.
31. Dugdale PE, Miles KA, Bunce I, Kelley BB, Leggett DA. CT measurement of perfusion and permeability within lymphoma masses and its ability to assess grade, activity, and chemotherapeutic response. J Comput Assist Tomogr 1999;23:540-7.
32. Leggett DA, Miles KA, Kelley BB. Blood-brain barrier and blood volume imaging of cerebral glioma using functional CT: A pictorial review. Australas Radiol 1998;42:335-40.
33. Roberts HC, Roberts TP, Brasch RC, Dillon WP. Quantitative measurement of microvascular permeability in human brain tumours achieved using dynamic contrast-enhanced MR imaging: Correlation with histologic grade. Am J Neuroradiol 2000;21:891-9.
34. Hermans R, Lambin P, Van Den Bogaert W, Haustermans K, Van Der Goten A, Baert AL. Non-invasive tumour perfusion measurement by dynamic CT: Preliminary results. Radiother Oncol 1997;44:159-62.
35. Miles KA, Leggett DA, Kelley BB, Hayball MP, Sinnatamby R, Bunce I. In vivo assessment of neovascularization of liver metastases using perfusion CT. Br J Radiol 1998;71:276-81.
36. Sommerfeld N, Miles K, Dugdale P, Leggett D, Bunce I. Colorectal cancer: Progressive disease is associated with altered liver perfusion on functional CT. In 50th Annual Meeting of the Royal Australia & New Zealand College of Radiologists. 1999.
37. Yeung WT, Lee TY, Del Maestro RF, Kozak R, Bennett J, Brown T. Effect of steroids on iopamidol blood-brain transfer constant and plasma volume in brain tumors measured with X-ray computed tomography. J Neurooncol 1994;18:53-60.
38. Ford J, Miles K, Hayball M, Bearcroft P, Bleehan N, Osborn C. A simplified method for measurement of blood-brain barrier permeability using CT: Preliminary results and the effect of RMP-7. In: Faulkner K et al, editors. Quantitative Imaging in Oncology. London: British Institute of Radiology, 1-5.
39. Falk SJ, Ramsay JR, Ward R, Miles K, Dixon AK, Bleehen NM. BW12C perturbs normal and tumour tissue oxygenation and blood flow in man. Radiother Oncol 1994;32:210-7.
40. Harvey C, Dooher A, Morgan J, Blomley M, Dawson P. Imaging of tumour therapy responses by dynamic CT. Eur J Radiol 1999;30:221-6.
41. Harvey CJ, Blomley MJ, Dawson P, Morgan JA, Dooher A, Deponte J, et al. Functional CT imaging of the acute hyperemic response to radiation therapy of the prostate gland: Early experience. J Comput Assist Tomogr 2001;25:43-9.
42. Li WW. Tumor angiogenesis: Molecular pathology, therapeutic targeting, and imaging. Acad Radiol 2000;7:800-11.
43. Miles K, Blomley M. Applications of perfusion CT. Functional Computed Tomography. Miles K, Dawson P, Blomley M, editors. Oxford ISIS Medical Media, 89-116.
44. Van Beers BE, Leconte I, Materne R, Smith AM, Jamart J, Horsmans Y. Hepatic perfusion parameters in chronic liver disease: Dynamic CT measurements correlated with disease severity. Am J Roentgenol 2001;176:667-73.
45. Tsushima Y, Blomley JK, Kusano S, Endo K. The portal component of hepatic perfusion measured by dynamic CT: An indicator of hepatic parenchymal damage. Dig Dis Sci 1999;44:1632-8.
46. Bader TR, Herneth AM, Blaicher W, Steininger R, Muhlbacher F, Lechner G, et al. Hepatic perfusion after liver transplantation: Noninvasive measurement with dynamic single-section CT. Radiology 1998;209:129-34.
47. Miles KA, McPherson SJ, Hayball MP. Transient splenic inhomogeneity with contrast-enhanced CT: Mechanism and effect of liver disease. Radiology 1995;194:91-5.
48. Miles KA, Leggett DA, Bennett GA. CT derived Patlak images of the human kidney. Br J Radiol 1999;72:153-8.
49. Blomley MJ, Dawson P. Review article: The quantification of renal function with enhanced computed tomography. Br J Radiol 1996;69:989-95.
50. Miles KA. Measurement of tissue perfusion by dynamic computed tomography. Br J Radiol 1991;64:409-12.
51. Miles KA, Hayball MP, Dixon AK. Functional imaging of changes in human intrarenal perfusion using quantitative dynamic computed tomography. Invest Radiol 1994;29:911-4.
52. Blomley MJ, McBride A, Mohammedtagi S, Albrecht T, Harvey CJ, Jager R, et al. Functional renal perfusion imaging with colour mapping: Is it a useful adjunct to spiral CT in the assessment of abdominal aortic aneurysm (AAA)? Eur J Radiol 1999;30:214-20.
53. Paul JF, Ugolini P, Sapoval M, Mousseaux E, Gaux JC. Unilateral renal artery stenosis: Perfusion patterns with electron-beam dynamic CT-preliminary experience. Radiology 2001;221:261-5.
54. Miles KA, Hayball MP, Dixon AK. Measurement of human pancreatic perfusion using dynamic computed tomography with perfusion imaging. Br J Radiol 1995;68:471-5.
55. Axel L. Tissue mean transit time from dynamic computed tomography by a simple deconvolution technique. Invest Radiol 1983;18:94-9.
56. Mullani N, Gould KL. First pass measurements of regional blood flow using external detectors. J Nucl Med 1983;24:577-81.
57. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983;3:1-7.
58. Gobbel GT, Cann CE, Fike JR. Measurement of regional cerebral blood flow using ultrafast computed tomography. Theoretical aspects. Stroke 1991;22:768-71.
59. Cenic A, Nabavi DG, Craen RA, Gelb AW, Lee TY. Dynamic CT measurement of cerebral blood flow: A validation study. Am J Neuroradiol 1999;20:63-73.
60. Cenic A, Nabavi DG, Craen RA, Gelb AW, Lee TY. A CT method to measure hemodynamics in brain tumors: Validation and application of cerebral blood flow maps. Am J Neuroradiol 2000;21:462-70.
61. Koenig M, Klotz E, Luka B, Venderink DJ, Spittler JF, Heuser L. Perfusion CT of the brain: Diagnostic approach for early detection of ischemic stroke. Radiology 1998;209:85-93.
62. FUNCTIONAL CT, in Mx8000 Operation Manual, Vol. 2. 2000, Philips Medical Systems. p. 11-1, 11-20.
63. Gobbel GT, Cann CE, Iwamoto HS, Fike JR. Measurement of regional cerebral blood flow in the dog using ultrafast computed tomography. Experimental validation. Stroke 1991;22:772-9.
64. Gobbel GT, Cann CE, Fike JR. Comparison of xenon-enhanced CT with ultrafast CT for measurement of regional cerebral blood flow. Am J Neuroradiol 1993;14:543-50.
65. Rumberger JA, Feiring AJ, Lipton MJ, Higgins CB, Ell SR, Marcus ML. Use of ultrafast computed tomography to quantitate regional myocardial perfusion: A preliminary report. J Am Coll Cardiol 1987;9:59-69.
66. Gould RG, Lipon MJ, McNamara MT, Sievers RE, Koshold S, Higgins CB. Measurement of regional myocardial blood flow in dogs by ultrafast CT. Invest Radiol 1988;23:348-53.
67. Blomley MJ, Coulden R, Bufkin C, Lipton MJ, Dawson P. Contrast bolus dynamic computed tomography for the measurement of solid organ perfusion. Invest Radiol 1993;28 Suppl. 5:S72-7; discussion S78.
68. Blomley MJ, Coulden R, Dawson P, Kormano M, Donlan P, Bufkin C, et al. Liver perfusion studied with ultrafast CT. J Comput Assist Tomogr 1995;19:424-33.
69. 2(15)O positron emission tomography. Neurol Res 2000;22:457-64.
70. Wintermark M, Thiran JP, Maeder P, Schnyder P, Meuli R. Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: A validation study. Am J Neuroradiol 2001;22:905-14.
71. Nabavi DG, Cenic A, Dool J, Smith RM, Espinosa F, Craen RA, et al. Quantitative assessment of cerebral hemodynamics using CT: Stability, accuracy, and precision studies in dogs. J Comput Assist Tomogr 1999;23:506-15.
72. Gillard JH, Antoun NM, Burnet NG, Pickard JD. Reproducibility of quantitative CT perfusion imaging. Br J Radiol 2001;74:552-5.
73. Wintermark M, Maeder P, Verdun FR, Thiran JP, Valley JF, Schnyder P, et al. Using 80 kVp versus 120 kVp in perfusion CT measurement of regional cerebral blood flow. Am J Neuroradiol 2000;21:1881-4.
74. Bell SD, Peters AM. Measurement of blood flow from first-pass radionuclide angiography: Influence of bolus volume. Eur J Nucl Med 1991;18:885-8.
75. Roberts HC, Roberts TP, Smith WS, Lee TJ, Fischbein NJ, Dillon WP. Multisection dynamic CT perfusion for acute cerebral ischemia: The "toggling-table" technique. Am J Neuroradiol 2001;22:1077-80.
76. Axel L. Cerebral blood flow determination by rapid-sequence computed tomography: Theoretical analysis. Radiology 1980;137:679-86.
77. Gobbel GT, Cann CE, Fike JR. Measurement of regional cerebral blood flow using ultrafast computed tomography. Theoretical aspects. Stroke 1991;22:768-71.
78. Harpen MD, Lecklitner ML. Derivation of gamma variate indicator dilution function from simple convective dispersion model of blood flow. Med Phys 1984;11:690-2.
79. Sapirstein LA. Regional blood flow by fractional distribution of indicators. Am J Physiol 1958;193:161-8.
80. Mullani N, Gould KL. First pass measurements of regional blood flow using external detectors. J Nucl Med 1983;24:577-81.
81. Meier P, Zieler K. On the Theory of the Indicator-Dilution Method for the measurement of blood flow and volume. J Appl Physiol 1954;6:731-44.
82. Axel L. Tissue mean transit time from dynamic computed tomography by a simple deconvolution technique. Invest Radiol 1983;18:94-9.
83. Yeung WT, Lee TY, Del Maestro RF, Kozak R, Bennett JD, Brown T. An absorptiometry method for the determination of arterial blood concentration of injected iodinated contrast agent. Phys Med Biol 1992;37:1741-58.
84. Cenic A, Nabavi DG, Craen RA, Gelb AW, Lee TY. A CT method to measure hemodynamics in brain tumors: Validation and application of cerebral blood flow maps. Am J Neuroradiol 2000;21:462-70.
85. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983;3:1-7.