The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective β3-adrenoceptor agonists

ChemMedChem

Volumn 4, Issue 12, 2009, Pages 2080-2097

  Perrone, Maria Grazia ^a   Bleve, Laura ^a   Santandrea, Ernesto ^a   Vitale, Paola ^a   Niso, Mauro ^a   Scilimati, Antonio ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

3 adrenergic receptors; Agonists; Arylethanolamines; Aryloxypropanolamines; Piperazine sulfonamides

Indexed keywords

1 (3 AMINOPHENOXY) 3 [4 (4 METHOXYPHENYLSULFONYL)PIPERAZIN 1 YL]PROPAN 2 OL; 1 (9H CARBAZOL 4 YLOXY) 3 [4 (4 METHOXYPHENYLSULFONYL)PIPERAZIN 1 YL]PROPAN 2 OL; 1 [4 (4 METHOXYPHENYLSULFONYL)PIPERAZIN 1 YL] 3 (3 NITROPHENOXY)PROPAN 2 OL; 1 [4 (4 METHOXYPHENYLSULFONYL)PIPERAZIN 1 YL] 3 (NAPHTHALEN 1 YLOXY)PROPAN 2 OL; 1 [4 (4 METHOXYPHENYLSULFONYL)PIPERAZIN 1 YL] 3 PHENOXYPROPAN 2 OL; 1 [4 (BENZYLOXY)PHENOXY] 3 [4 (4 METHOXYPHENYLSULFONYL)PIPERAZIN 1 YL]PROPAN 2 OL; 1 [4 [4 (2 HYDROXY 2 PHENYLETHYLAMINO)PIPERIDIN 1 YLSULFONYL]PHENYL] 3 OCTYLUREA; 2 [1 (4 METHOXYPHENYLSULFONYL)PIPERIDIN 4 YLAMINO] 1 (PYRIDIN 3 YL)ETHANOL; 2 [1 (4 METHOXYPHENYLSULFONYL)PIPERIDIN 4 YLAMINO] 1 PHENYLETHANOL; 2 [4 [4 (2 HYDROXY 2 PHENYLETHYLAMINO)PIPERIDIN 1 YLSULFONYL]PHENOXY]ACETIC ACID; 2 [4 [N [4 [2 [2 HYDROXY 3 (4 HYDROXYPHENOXY)PROPYLAMINO]ETHYL]PHENYL]SULFAMOYL]PHENOXY]ACETIC ACID; 3 [4 [N [4 [2 [2 HYDROXY 3 (4 HYDROXYPHENOXY)PROPYLAMINO]ETHYL]PHENYL]SULFAMOYL]PHENOXY]PROPANOIC ACID; 4 [2 HYDROXY 3 [4 (4 METHOXYPHENYLSULFONYL)PIPERAZIN 1 YL]PROPOXY]PHENOL; AMINE; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; ETHYL 2 [4 [4 (2 HYDROXY 2 PHENYLETHYLAMINO)PIPERIDIN 1 YLSULFONYL]PHENOXY]ACETIC ACID; ETHYL 2 [4 [N [4 [2 (2 HYDROXY 2 PHENYLETHYLAMINO)ETHYL]PHENYL]SULFAMOYL]PHENOXY]ACETIC ACID; ETHYL 2 [4 [N [4 [2 [2 HYDROXY 3 (4 HYDROXYPHENOXY)PROPYLAMINO]ETHYL]PHENYL]SULFAMOYL]PHENOXY]ACETIC ACID; ETHYL 3 [4 [4 (2 HYDROXY 2 PHENYLETHYLAMINO)PIPERIDIN 1 YLSULFONYL]PHENOXY]PROPANOIC ACID; ETHYL 3 [4 [N [4 [2 (2 HYDROXY 2 PHENYLETHYLAMINO)ETHYL]PHENYL]SULFAMOYL]PHENOXY]PROPANOIC ACID; ETHYL 3 [4 [N [4 [2 [2 HYDROXY 3 (4 HYDROXYPHENOXY)PROPYLAMINO]ETHYL]PHENYL]SULFAMOYL]PHENOXY]PROPANOIC ACID; N [3 [2 HYDROXY 3 [4 (4 METHOXYPHENYLSULFONYL)PIPERAZIN 1 YL]PROPOXY]PHENYL]BENZENESULFONAMIDE; N [3 [2 HYDROXY 3 [4 (4 METHOXYPHENYLSULFONYL)PIPERAZIN 1 YL]PROPOXY]PHENYL]METHANESULFONAMIDE; N [3 [2 HYDROXY 3 [4 (4 METHOXYPHENYLSULFONYL)PIPERAZIN 1 YL]PROPOXY]PHENYL]THIOPHENE 2 SULFONAMIDE; N [4 [2 (2 HYDROXY 2 PHENYLETHYLAMINO)ETHYL]PHENYL] 4 (3 OCTYLUREIDO)BENZENESULFONAMIDE; NITROGEN; PIPERAZINE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PRIORITY JOURNAL;

AMINES; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; GENE EXPRESSION; HUMANS; MOLECULAR STRUCTURE; PIPERAZINES; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, ADRENERGIC, BETA-3; SULFONAMIDES;

EID: 73449099637     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900292     Document Type: Article

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