Age-related accumulation of mutations supports a replication-dependent mechanism of spontaneous mutation at tandem repeat DNA loci in mice

Molecular Biology and Evolution

Volumn 26, Issue 11, 2009, Pages 2647-2654

  Hardwick, Robert J ^a   Tretyakov, Michael V ^a   Dubrova, Yuri E ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Age; Expanded simple tandem repeat loci; Mouse; Mutation

Indexed keywords

DNA; PROTEIN;

ACCURACY; AGE DETERMINATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; BRAIN; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; DNA REPLICATION; EXPANDED SIMPLE TANDEM REPEAT; GENE FREQUENCY; GENE LOCUS; MALE; MAMMAL; MICROSATELLITE MARKER; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; POLYMERASE CHAIN REACTION; SPERM; SPONTANEOUS MUTATION; TANDEM REPEAT; AGING; ANIMAL; GENETICS; MUTATION; THEORETICAL MODEL;

MAMMALIA; MUS;

AGING; ANIMALS; MALE; MICE; MODELS, THEORETICAL; MUTATION; POLYMERASE CHAIN REACTION; TANDEM REPEAT SEQUENCES;

EID: 73349135938     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msp182     Document Type: Article

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