The estimation of in vivo mutation rate and frequency samples of human lymphocytes

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 357, Issue 1-2, 1996, Pages 167-176

  Morley, Alexander A ^a  

^a FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; HUMAN; HUMAN CELL; IN VIVO STUDY; LYMPHOCYTE; MUTATION RATE; PRIORITY JOURNAL; T LYMPHOCYTE;

LURIA;

EID: 0030601699     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(96)00096-6     Document Type: Article

References (13)

1. [1] Luria, S.W. and M. Delbruck (1943) Mutation of bacteria from virus sensitivity to virus resistance, Genetics, 28, 491-511.
2. [2] Korsmeyer, S.J., A. Arnold, A. Bakhshi et al. (1983) Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukaemias of T cell and B cell precursor origins, J. Clin. Invest., 71, 301-313.
3. [3] Trainor, K.J., M.J. Brisco, C.J. Story and A.A. Morley (1990) Monoclonality in B-lymphoproliferative disorders detected at the DNA level, Blood, 75, 2220-2222.
4. [4] Trainor, K.J., M.J. Brisco, J.H. Wan, S. Neoh, S. Grist and A.A. Morley (1991) Gene rearrangement in B and T lymphoproliferative disease detected by the polymerase chain reaction, Blood 78, 192-196.
5. [5] O'Neill, J.P. et al. (1994) The effect of T-lymphocyte 'clonality' on the calculated hprt mutation frequency occurring in vivo in humans, Mutation Res., 313, 215-225.
6. [6] Curry, J., G.T. Rowley, V. Saddi, D. Beare, J. Cole and B.W. Glickman (1995) Determination of hprt mutant and mutation frequencies and the molecular characterisation of human derived in vivo T-lymphocyte mutants, Environ. Mol. Mutagen., 25, 167-169.
7. [7] Albertini, R.J. and R. De Mars (1974) Mosaicism of peripheral blood lymphocyte populations in females heterozygous for the Lesch-Nyhan mutation, Biochem. Genet., 11, 397-411.
8. [8] Dempsey, J.L., A.A. Morley, R.S. Seshadri, B.T. Emmerson, R. Gordon and C.I. Bhagat (1983) Detection of the carrier state for an X-linked disorder, the Lesch-Nyhan syndrome, by the use of lymphocyte cloning, Hum. Genet., 64, 288-290.
9. [9] Grist, S.A., M, McCarron, A, Kutlaca, D.R. Turner and A.A. Morley (1992) In vivo human somatic mutation frequency and spectrum with age, Mutation Res., 266, 189-196.
10. [10] Green, M.H.L., J.P. O'Neill and J. Cole (1995) Suggestions concerning the relationship between mutant frequency and mutation rate at the hprt locus in human peripheral T-lymphocytes, Mutation Res., 334, 323-339.
11. [11] Lea, D.E. and C.A. Coulson (1949) The distribution of numbers of mutants in bacterial populations, J. Genet., 49, 264-285.
12. [12] Seshadri, R., R. Kutlaca, K. Trainor, C. Matthews, C. and A.A. Morley (1987) Mutation rate of normal and malignant human lymphocytes, Cancer Res., 47, 407-409.
13. [13] Nicklas, J.A., J.P. O'Neill, L.M. Sullivan, T.C. Hunter, M. Allegretta, B.F. Chastenay, B.L. Libbus and R.J. Albertini (1988) Molecular analyses of in vivo hypoxanthine-guanine phosphoribosyl transferase mutations in human T-lymphocytes. II. Demonstration of a clonal amplification of hprt mutant T-lympocytes in vivo, Environ. Mol. Mutagen., 12, 271-284.