Is there an answer? Can resveratrol extend your life?

IUBMB Life

Volumn 61, Issue 10, 2009, Pages 1010-1011

  Azzi, Angelo ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; RESVERATROL; RESVERT; UNCLASSIFIED DRUG; STILBENE DERIVATIVE;

AGING; ANTIINFLAMMATORY ACTIVITY; CALORIC RESTRICTION; CARCINOGENESIS; DRUG ACTIVITY; HEART PROTECTION; HUMAN; LIFESPAN; LONGEVITY; NEUROPROTECTION; NONHUMAN; NOTE; ARTICLE; CLINICAL TRIAL; LIFE EXPECTANCY;

CLINICAL TRIALS AS TOPIC; HUMANS; LIFE EXPECTANCY; STILBENES;

EID: 73349126440     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.250     Document Type: Note

References (6)

1. Boocock, D. J., Faust, G. E., Patel, K. R., Schinas, A. M., Brown, V. A., Ducharme, M. P., Booth, T. D., Crowell, J. A., Perloff, M., Gescher, A. J., Steward, W. P., and Brenner, D. E. (2007) Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev. 16, 1246-1252. (Pubitemid 46984966)
2. Olshansky, S. J., Hayflick, L., and Carnes, B. A. (2002) Position statement on human aging. J. Gerontol. A Biol. Sci. Med. Sci. 57, B292-B297.
3. Valenzano, D. R. and Cellerino, A. (2006) Resveratrol and the pharmacology of aging: a new vertebrate model to validate an old molecule. Cell Cycle 5, 1027-1032.
4. Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L. L., Scherer, B., and Sinclair, D. A. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-196. (Pubitemid 37150899)
5. Guarente, L. (2007) Sirtuins in aging and disease. Cold Spring Harb. Symp. Quant. Biol. 72, 483-488.
6. Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., Jamieson, H. A., Zhang, Y., Dunn, S. R., Sharma, K., Pleshko, N., Woollett, L. A., Csiszar, A., Ikeno, Y., Le Couteur, D., Elliott, P. J., Becker, K. G., Navas, P., Ingram, D. K., Wolf, N. S., Ungvari, Z., Sinclair, D. A., and de Cabo, R. (2008) Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 8, 157-168.