A novel DNA vaccine containing multiple TB-specific epitopes cast in a natural structure elicits enhanced Th1 immunity compared with BCG

Microbiology and Immunology

Volumn 53, Issue 10, 2009, Pages 541-549

  Gao, Haifeng ^a   Li, Kang ^a   Yu, Shanshan ^a   Xiong, Sidong ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

DNA vaccine; ECNAS; Epitope

Indexed keywords

ANTIGEN; BCG VACCINE; CD4 ANTIGEN; CD8 ANTIGEN; CULTURE FILTRATE PROTEIN 10; DNA VACCINE; EARLY SECRETORY ANTIGENIC TARGET 6; EPITOPE; GAMMA INTERFERON; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEAT SHOCK PROTEIN 65; INTERLEUKIN 10; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN; PROTEIN AG85A; PROTEIN AG85B; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ACYLTRANSFERASE; ANTIGEN 85A, MYCOBACTERIUM TUBERCULOSIS; BACTERIAL ANTIGEN; BACTERIAL DNA; BACTERIAL PROTEIN; CFP 10 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; CFP-10 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; CHAPERONIN; ESAT 6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; ESAT-6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; HEAT SHOCK PROTEIN 65, MYCOBACTERIUM; HEAT-SHOCK PROTEIN 65, MYCOBACTERIUM;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHIMERA; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; DNA IMMUNIZATION; DRUG EFFICACY; FEMALE; HUMAN; HUMORAL IMMUNITY; INTERFERON PRODUCTION; LYMPHOCYTE PROLIFERATION; MOLECULAR CLONING; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN DOMAIN; TH1 CELL; TUBERCULOSIS; VACCINATION; ANIMAL; COMPARATIVE STUDY; GENETICS; IMMUNOLOGY; LUNG TUBERCULOSIS;

MUS; MYCOBACTERIUM TUBERCULOSIS;

ACYLTRANSFERASES; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BCG VACCINE; CHAPERONIN 60; DNA, BACTERIAL; EPITOPES, T-LYMPHOCYTE; FEMALE; HUMANS; MICE; MYCOBACTERIUM TUBERCULOSIS; TH1 CELLS; TUBERCULOSIS VACCINES; TUBERCULOSIS, PULMONARY; VACCINES, DNA;

EID: 73349124497     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2009.00157.x     Document Type: Article

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