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Volumn 72, Issue 11, 2009, Pages 1980-1987

Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; LAETIROBIN; PLANT EXTRACT; UNCLASSIFIED DRUG; BENZOFURAN DERIVATIVE;

EID: 73349123181     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np9002838     Document Type: Article
Times cited : (20)

References (41)
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    • Gordaliza, M. Clin. Transl. Oncol. 2007, 9, 767-776.
    • (d) Gordaliza, M. Clin. Transl. Oncol. 2007, 9, 767-776.
  • 14
    • 15744401951 scopus 로고    scopus 로고
    • For natural products obtained from L. sulphureus, see: (a) Davoli, P.; Mucci, A.; Schenetti, L.; Weber, R. W. Phytochemistry 2005, 66, 817-823.
    • For natural products obtained from L. sulphureus, see: (a) Davoli, P.; Mucci, A.; Schenetti, L.; Weber, R. W. Phytochemistry 2005, 66, 817-823.
  • 15
    • 11844249348 scopus 로고    scopus 로고
    • León, F.; Quintana, J.; Rivera, ?.; Estévez, F.; Bermejo, J. J. Nat. Prod. 2004, 67, 2008-2011.
    • (b) León, F.; Quintana, J.; Rivera, ?.; Estévez, F.; Bermejo, J. J. Nat. Prod. 2004, 67, 2008-2011.
  • 16
    • 0035087141 scopus 로고    scopus 로고
    • The latter reference is particularly relevant, as it identifies a monobenzofuran that exhibited cytotoxicity against Kato III cells
    • (c) Yoshikawa, K.; Bando, S.; Arihara, S.; Matsumura, E. Chem. Pharm. Bull. 2001, 49, 327-329. The latter reference is particularly relevant, as it identifies a monobenzofuran that exhibited cytotoxicity against Kato III cells.
    • (2001) Chem. Pharm. Bull , vol.49 , pp. 327-329
    • Yoshikawa, K.1    Bando, S.2    Arihara, S.3    Matsumura, E.4
  • 22
    • 73549094303 scopus 로고    scopus 로고
    • Jackman, J.; O'Connor, P. M. Curr. Protoc. Cell. Biol. 2001, 8.3, 1-20.
    • Jackman, J.; O'Connor, P. M. Curr. Protoc. Cell. Biol. 2001, 8.3, 1-20.
  • 23
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    • Although sufficient for guiding the isolation of 1, this process failed to provide sufficient quantities of probe 3 for characterization by NMR analysis. As probe 3 was unnecessary for this study, we did not prepare samples for structural assignment. Efforts are ongoing to apply IAFlabeling methods to develop active probes for molecular and cellular studies as well as to define the structure-activity relationships of 1. These efforts will be reported in due course
    • Although sufficient for guiding the isolation of 1, this process failed to provide sufficient quantities of probe 3 for characterization by NMR analysis. As probe 3 was unnecessary for this study, we did not prepare samples for structural assignment. Efforts are ongoing to apply IAFlabeling methods to develop active probes for molecular and cellular studies as well as to define the structure-activity relationships of 1. These efforts will be reported in due course.
  • 24
    • 0035207013 scopus 로고    scopus 로고
    • The 1024 m/z peak identified from probe 3 during reverse-affinity purification was used to guide preparative isolation of compound 1 (steps h-m, Figure 1). For procedures for DCVC, see: Pedersen, D. S.; Rosenbohm, C. Synthesis 2001, 16, 2431-2434.
    • The 1024 m/z peak identified from probe 3 during reverse-affinity purification was used to guide preparative isolation of compound 1 (steps h-m, Figure 1). For procedures for DCVC, see: Pedersen, D. S.; Rosenbohm, C. Synthesis 2001, 16, 2431-2434.
  • 25
    • 73549112051 scopus 로고    scopus 로고
    • The use of H/C ratios to determine the applicability of NMR methods was first described by: Crews, P. US-Japan Conference on Marine Natural Products Chemistry (June 2007).
    • The use of H/C ratios to determine the applicability of NMR methods was first described by: Crews, P. US-Japan Conference on Marine Natural Products Chemistry (June 2007).
  • 37
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    • However, they are more commonly obtained from plant extracts. For recent examples describing the isolation of benzofuran-containing natural products from plants, see: b
    • However, they are more commonly obtained from plant extracts. For recent examples describing the isolation of benzofuran-containing natural products from plants, see: (b) Shen, H.; Hou, A. J. Nat. Prod. Res. 2008, 22, 1451-1456.
    • (2008) J. Nat. Prod. Res , vol.22 , pp. 1451-1456
    • Shen, H.1    Hou, A.2
  • 40
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    • We have recently completed a total synthesis of (±)-laetirobin (1) that suggests that the biosynthesis arises through a homodimeric Diels - Alder cycloaddition; see: Simon, O.; Reux, B., La Clair, J. J.; Lear, M. J. Chem Asian J., in review.
    • We have recently completed a total synthesis of (±)-laetirobin (1) that suggests that the biosynthesis arises through a homodimeric Diels - Alder cycloaddition; see: Simon, O.; Reux, B., La Clair, J. J.; Lear, M. J. Chem Asian J., in review.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.