-
4
-
-
39149098194
-
-
Gordaliza, M. Clin. Transl. Oncol. 2007, 9, 767-776.
-
(d) Gordaliza, M. Clin. Transl. Oncol. 2007, 9, 767-776.
-
-
-
-
6
-
-
33645816334
-
-
(f) Jones, W. P.; Chin, Y. W.; Kinghorn, A. D. Curr. Drug Targets 2006, 7, 247-264.
-
(2006)
Curr. Drug Targets
, vol.7
, pp. 247-264
-
-
Jones, W.P.1
Chin, Y.W.2
Kinghorn, A.D.3
-
10
-
-
36749048735
-
-
(a) Ryan, R. P.; Germaine, K.; Franks, A.; Ryan, D. J.; Dowling, D. N. FEMS Microbiol. Lett. 2008, 278, 1-9.
-
(2008)
FEMS Microbiol. Lett
, vol.278
, pp. 1-9
-
-
Ryan, R.P.1
Germaine, K.2
Franks, A.3
Ryan, D.J.4
Dowling, D.N.5
-
11
-
-
33748991468
-
-
(b) Zhang, H. W.; Song, Y. C.; Tan, R. X. Nat. Prod. Rep. 2006, 23, 753-771.
-
(2006)
Nat. Prod. Rep
, vol.23
, pp. 753-771
-
-
Zhang, H.W.1
Song, Y.C.2
Tan, R.X.3
-
13
-
-
34547641010
-
-
Steinkellner, S.; Lendzemo, V.; Langer, I.; Schweiger, P.; Khaosaad, T.; Toussaint, J. P.; Vierheilig, H. Molecules 2007, 5, 1290-1306.
-
(2007)
Molecules
, vol.5
, pp. 1290-1306
-
-
Steinkellner, S.1
Lendzemo, V.2
Langer, I.3
Schweiger, P.4
Khaosaad, T.5
Toussaint, J.P.6
Vierheilig, H.7
-
14
-
-
15744401951
-
-
For natural products obtained from L. sulphureus, see: (a) Davoli, P.; Mucci, A.; Schenetti, L.; Weber, R. W. Phytochemistry 2005, 66, 817-823.
-
For natural products obtained from L. sulphureus, see: (a) Davoli, P.; Mucci, A.; Schenetti, L.; Weber, R. W. Phytochemistry 2005, 66, 817-823.
-
-
-
-
15
-
-
11844249348
-
-
León, F.; Quintana, J.; Rivera, ?.; Estévez, F.; Bermejo, J. J. Nat. Prod. 2004, 67, 2008-2011.
-
(b) León, F.; Quintana, J.; Rivera, ?.; Estévez, F.; Bermejo, J. J. Nat. Prod. 2004, 67, 2008-2011.
-
-
-
-
16
-
-
0035087141
-
-
The latter reference is particularly relevant, as it identifies a monobenzofuran that exhibited cytotoxicity against Kato III cells
-
(c) Yoshikawa, K.; Bando, S.; Arihara, S.; Matsumura, E. Chem. Pharm. Bull. 2001, 49, 327-329. The latter reference is particularly relevant, as it identifies a monobenzofuran that exhibited cytotoxicity against Kato III cells.
-
(2001)
Chem. Pharm. Bull
, vol.49
, pp. 327-329
-
-
Yoshikawa, K.1
Bando, S.2
Arihara, S.3
Matsumura, E.4
-
18
-
-
44949095586
-
-
(a) Rodríguez, A. D.; Lear, M. J.; La Clair, J. J. J. Am. Chem. Soc. 2008, 130, 7256-7258.
-
(2008)
J. Am. Chem. Soc
, vol.130
, pp. 7256-7258
-
-
Rodríguez, A.D.1
Lear, M.J.2
La Clair, J.J.3
-
19
-
-
58249095065
-
-
(b) Hughes, C. C.; MacMillan, J. B.; Gaudêncio, S. P.; Fenical, W.; La Clair, J. J. Angew. Chem., Int. Ed. 2009, 48, 728-732.
-
(2009)
Angew. Chem., Int. Ed
, vol.48
, pp. 728-732
-
-
Hughes, C.C.1
MacMillan, J.B.2
Gaudêncio, S.P.3
Fenical, W.4
La Clair, J.J.5
-
20
-
-
33644914163
-
-
Alexander, M. D.; Burkart, M. D.; Leonard, M. S.; Portonovo, P.; Liang, B.; Ding, X.; Joullie, M. M.; Gulledge, B. M.; Aggen, J. B.; Chamberlin, A. R.; Sandler, J.; Fenical, W.; Cui, J.; Gharpure, S. J.; Polosukhin, A.; Zhang, H. R.; Evans, P. A.; Richardson, A. D.; Harper, M. K.; Ireland, C. M.; Vong, B. G.; Brady, T. P.; Theodorakis, E. A.; La Clair, J. J. ChemBioChem 2006, 7, 409-416.
-
(2006)
ChemBioChem
, vol.7
, pp. 409-416
-
-
Alexander, M.D.1
Burkart, M.D.2
Leonard, M.S.3
Portonovo, P.4
Liang, B.5
Ding, X.6
Joullie, M.M.7
Gulledge, B.M.8
Aggen, J.B.9
Chamberlin, A.R.10
Sandler, J.11
Fenical, W.12
Cui, J.13
Gharpure, S.J.14
Polosukhin, A.15
Zhang, H.R.16
Evans, P.A.17
Richardson, A.D.18
Harper, M.K.19
Ireland, C.M.20
Vong, B.G.21
Brady, T.P.22
Theodorakis, E.A.23
La Clair, J.J.24
more..
-
22
-
-
73549094303
-
-
Jackman, J.; O'Connor, P. M. Curr. Protoc. Cell. Biol. 2001, 8.3, 1-20.
-
Jackman, J.; O'Connor, P. M. Curr. Protoc. Cell. Biol. 2001, 8.3, 1-20.
-
-
-
-
23
-
-
73549095240
-
-
Although sufficient for guiding the isolation of 1, this process failed to provide sufficient quantities of probe 3 for characterization by NMR analysis. As probe 3 was unnecessary for this study, we did not prepare samples for structural assignment. Efforts are ongoing to apply IAFlabeling methods to develop active probes for molecular and cellular studies as well as to define the structure-activity relationships of 1. These efforts will be reported in due course
-
Although sufficient for guiding the isolation of 1, this process failed to provide sufficient quantities of probe 3 for characterization by NMR analysis. As probe 3 was unnecessary for this study, we did not prepare samples for structural assignment. Efforts are ongoing to apply IAFlabeling methods to develop active probes for molecular and cellular studies as well as to define the structure-activity relationships of 1. These efforts will be reported in due course.
-
-
-
-
24
-
-
0035207013
-
-
The 1024 m/z peak identified from probe 3 during reverse-affinity purification was used to guide preparative isolation of compound 1 (steps h-m, Figure 1). For procedures for DCVC, see: Pedersen, D. S.; Rosenbohm, C. Synthesis 2001, 16, 2431-2434.
-
The 1024 m/z peak identified from probe 3 during reverse-affinity purification was used to guide preparative isolation of compound 1 (steps h-m, Figure 1). For procedures for DCVC, see: Pedersen, D. S.; Rosenbohm, C. Synthesis 2001, 16, 2431-2434.
-
-
-
-
25
-
-
73549112051
-
-
The use of H/C ratios to determine the applicability of NMR methods was first described by: Crews, P. US-Japan Conference on Marine Natural Products Chemistry (June 2007).
-
The use of H/C ratios to determine the applicability of NMR methods was first described by: Crews, P. US-Japan Conference on Marine Natural Products Chemistry (June 2007).
-
-
-
-
28
-
-
0030924824
-
-
(b) Jonker, A.; Geerts, W. J.; Chieco, P.; Moorman, A. F.; Lamers, W. H.; Van Noorden, C. J. Histochem. J. 1997, 29, 347-364.
-
(1997)
Histochem. J
, vol.29
, pp. 347-364
-
-
Jonker, A.1
Geerts, W.J.2
Chieco, P.3
Moorman, A.F.4
Lamers, W.H.5
Van Noorden, C.J.6
-
29
-
-
1642462152
-
-
Lemieux, B.; Percival, M. D.; Falgueyret, J. P. Anal. Biochem. 2004, 327, 247-251.
-
(2004)
Anal. Biochem
, vol.327
, pp. 247-251
-
-
Lemieux, B.1
Percival, M.D.2
Falgueyret, J.P.3
-
31
-
-
0019204956
-
-
Verderame, M.; Alcorta, D.; Egnor, M.; Smith, K.; Pollack, R. Proc. Natl. Acad. Sci. U.S.A. 1980, 77, 6624-6628.
-
(1980)
Proc. Natl. Acad. Sci. U.S.A
, vol.77
, pp. 6624-6628
-
-
Verderame, M.1
Alcorta, D.2
Egnor, M.3
Smith, K.4
Pollack, R.5
-
32
-
-
33846523617
-
-
For recent perspectives on antimitotic agents, see: a
-
For recent perspectives on antimitotic agents, see: (a) Jackson, J. R.; Patrick, D. R.; Dar, M. M.; Huang, P. S. Nat. Rev. Cancer 2007, 7, 107-117.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 107-117
-
-
Jackson, J.R.1
Patrick, D.R.2
Dar, M.M.3
Huang, P.S.4
-
33
-
-
34648825331
-
-
(b) Ruchaud, S.; Carmena, M.; Earnshaw, W. C. Nat. Rev. Mol. Cell Biol. 2007, 8, 798-812.
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, pp. 798-812
-
-
Ruchaud, S.1
Carmena, M.2
Earnshaw, W.C.3
-
34
-
-
37449016062
-
-
(c) Ivachtchenko, A. V.; Kiselyov, A. S.; Tkachenko, S. E.; Ivanenkov, Y. A.; Balakin, K. V. Curr. Cancer Drug Targets 2007, 7, 766-784.
-
(2007)
Curr. Cancer Drug Targets
, vol.7
, pp. 766-784
-
-
Ivachtchenko, A.V.1
Kiselyov, A.S.2
Tkachenko, S.E.3
Ivanenkov, Y.A.4
Balakin, K.V.5
-
36
-
-
11844302219
-
-
Benzofuran-containing natural products have been observed in fungi; see: a
-
Benzofuran-containing natural products have been observed in fungi; see: (a) Manniche, S.; Sprogøe, K.; Dalsgaard, P. W.; Christophersen, C.; Larsen, T. O. J. Nat. Prod. 2004, 67, 2111.
-
(2004)
J. Nat. Prod
, vol.67
, pp. 2111
-
-
Manniche, S.1
Sprogøe, K.2
Dalsgaard, P.W.3
Christophersen, C.4
Larsen, T.O.5
-
37
-
-
57049152420
-
-
However, they are more commonly obtained from plant extracts. For recent examples describing the isolation of benzofuran-containing natural products from plants, see: b
-
However, they are more commonly obtained from plant extracts. For recent examples describing the isolation of benzofuran-containing natural products from plants, see: (b) Shen, H.; Hou, A. J. Nat. Prod. Res. 2008, 22, 1451-1456.
-
(2008)
J. Nat. Prod. Res
, vol.22
, pp. 1451-1456
-
-
Shen, H.1
Hou, A.2
-
38
-
-
58049199372
-
-
(c) Chen, T. H.; Liau, B. C.; Wang, S. Y.; Jong, T. T. Planta Med. 2008, 74, 1806-1811.
-
(2008)
Planta Med
, vol.74
, pp. 1806-1811
-
-
Chen, T.H.1
Liau, B.C.2
Wang, S.Y.3
Jong, T.T.4
-
39
-
-
56049085352
-
-
(d) Ross, S. A.; Rodríguez-Guzmán, R.; Radwan, M. M.; Jacob, M.; Ding, Y.; Li, X. C.; Ferreira, D.; Manly, S. P. J. Nat. Prod. 2008, 71, 1764-1767.
-
(2008)
J. Nat. Prod
, vol.71
, pp. 1764-1767
-
-
Ross, S.A.1
Rodríguez-Guzmán, R.2
Radwan, M.M.3
Jacob, M.4
Ding, Y.5
Li, X.C.6
Ferreira, D.7
Manly, S.P.8
-
40
-
-
73549083484
-
-
We have recently completed a total synthesis of (±)-laetirobin (1) that suggests that the biosynthesis arises through a homodimeric Diels - Alder cycloaddition; see: Simon, O.; Reux, B., La Clair, J. J.; Lear, M. J. Chem Asian J., in review.
-
We have recently completed a total synthesis of (±)-laetirobin (1) that suggests that the biosynthesis arises through a homodimeric Diels - Alder cycloaddition; see: Simon, O.; Reux, B., La Clair, J. J.; Lear, M. J. Chem Asian J., in review.
-
-
-
-
41
-
-
0032952083
-
-
Sapan, C. V.; Lundblad, R. L.; Price, N. C. Biotechnol. Appl. Biochem. 1999, 29, 99-108.
-
(1999)
Biotechnol. Appl. Biochem
, vol.29
, pp. 99-108
-
-
Sapan, C.V.1
Lundblad, R.L.2
Price, N.C.3
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