Central and peripheral effects of thyroid hormone signalling in the control of energy metabolism

Journal of Neuroendocrinology

Volumn 22, Issue 1, 2010, Pages 56-63

  Alkemade, A ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Deiodinase; Hyperthyroidism; Hypothalamus; Paraventricular nucleus; Thyroid hormone receptor

Indexed keywords

GLUCOSE; LIOTHYRONINE; LIPID; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 8; NEUROPEPTIDE Y; PROTIRELIN; THYROID HORMONE; THYROID HORMONE RECEPTOR; THYROID HORMONE RECEPTOR ALPHA; THYROID HORMONE RECEPTOR BETA; THYROXINE; THYROXINE DEIODINASE; UNCOUPLING PROTEIN 1;

ADRENERGIC TRANSMISSION; ARTICLE; AUTONOMIC NERVOUS SYSTEM; DENERVATION; ENERGY METABOLISM; GENE MUTATION; GLUCOSE METABOLISM; HUMAN; HYPERTHYROIDISM; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; LIPID METABOLISM; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THERMOGENESIS; TRANSCRIPTION REGULATION;

ANIMALS; ENERGY METABOLISM; HYPOTHALAMUS; NEURONS; RECEPTORS, THYROID HORMONE; THYROID HORMONES;

EID: 73349096632     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2009.01932.x     Document Type: Article

References (54)

1. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 2002, 23:38-89.
2. Maia AL, Kim BW, Huang SA, Harney JW, Larsen PR. Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. J Clin Invest 2005, 115:2524-2533.
3. Maia AL. Type 1 iodothyronine deiodinase is the major source of circulating T3 in hyperthyroidism: implications for therapy. Nat Clin Pract Endocrinol Metab 2007, 3:740-741.
4. Schneider MJ, Fiering SN, Thai B, Wu SY, St GE, Parlow AF, St GermainDL, Galton VA. Targeted disruption of the type 1 selenodeiodinase gene (Dio1) results in marked changes in thyroid hormone economy in mice. Endocrinology 2006, 147:580-589.
5. Larsen PR. Type 2 iodothyronine deiodinase in human skeletal muscle: new insights into its physiological role and regulation. J Clin Endocrinol Metab 2009, 94:1893-1895.
6. Heemstra KA, Soeters MR, Fliers E, Serlie MJ, Burggraaf J, van Doorn MB, van der Klaauw AA, Romijn JA, Smit JW, Corssmit EP, Visser TJ. Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting. J Clin Endocrinol Metab 2009, 94:2144-2150.
7. Grozovsky R, Ribich S, Rosene ML, Mulcahey MA, Huang SA, Patti ME, Bianco AC, Kim BW. Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. Endocrinology 2009, 150:1976-1983.
8. Visser WE, Friesema EC, Jansen J, Visser TJ. Thyroid hormone transport in and out of cells. Trends Endocrinol Metab 2008, 19:50-56.
9. Sap J, Munoz A, Damm K, Goldberg Y, Ghysdael J, Leutz A, Beug H, Vennstrom B. The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature 1986, 324:635-640.
10. Dillmann WH. Cellular action of thyroid hormone on the heart. Thyroid 2002, 12:447-452.
11. Gullberg H, Rudling M, Salto C, Forrest D, Angelin B, Vennstrom B. Requirement for thyroid hormone receptor beta in T3 regulation of cholesterol metabolism in mice. Mol Endocrinol 2002, 16:1767-1777.
12. Alkemade A, Vuijst CL, Unmehopa UA, Bakker O, Vennstrom B, Wiersinga WM, Swaab DF, Fliers E. Thyroid hormone receptor expression in the human hypothalamus and anterior pituitary. J Clin Endocrinol Metab 2005, 90:904-912.
13. Legradi G, Lechan RM. The arcuate nucleus is the major source for neuropeptide Y-innervation of thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 1998, 139:3262-3270.
14. Tu HM, Kim SW, Salvatore D, Bartha T, Legradi G, Larsen PR, Lechan RM. Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone. Endocrinology 1997, 138:3359-3368.
15. Alkemade A, Friesema EC, Unmehopa UA, Fabriek BO, Kuiper GG, Leonard JL, Wiersinga WM, Swaab DF, Visser TJ, Fliers E. Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus. J Clin Endocrinol Metab 2005, 90:4322-4334.
16. Schneider MJ, Fiering SN, Pallud SE, Parlow AF, St GD, Galton VA. Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4. Mol Endocrinol 2001, 15:2137-2148.
17. Alkemade A, Friesema EC, Kuiper GG, Wiersinga WM, Swaab DF, Visser TJ, Fliers E. Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary. Eur J Endocrinol 2006, 154:491-500.
18. Segerson TP, Kauer J, Wolfe HC, Mobtaker H, Wu P, Jackson IM, Lechan RM. Thyroid hormone regulates TRH biosynthesis in the paraventricular nucleus of the rat hypothalamus. Science 1987, 238:78-80.
19. Abel ED, Ahima RS, Boers ME, Elmquist JK, Wondisford FE. Critical role for thyroid hormone receptor beta2 in the regulation of paraventricular thyrotropin-releasing hormone neurons. J Clin Invest 2001, 107:1017-1023.
20. Cook CB, Kakucska I, Lechan RM, Koenig RJ. Expression of thyroid hormone receptor beta 2 in rat hypothalamus. Endocrinology 1992, 130:1077-1079.
21. Boelen A, Kwakkel J, Chassande O, Fliers E. Thyroid hormone receptor beta mediates acute illness-induced alterations in central thyroid hormone metabolism. J Neuroendocrinol 2009, in press
22. Silva JE, Braverman LE, Utiger RD. Intermediary metabolism and the sympathoadrenal systen in hypothyrodism. Werner and Ingbar's The Thyroid 2009, 817-823. In, eds, 9th edn, Philadelphia, Lippincott Williams & Wilkins
23. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerback S, Nuutila P. Functional brown adipose tissue in healthy adults. N Engl J Med 2009, 360:1518-1525.
24. Silva JE, Bianco SD. Thyroid-adrenergic interactions: physiological and clinical implications. Thyroid 2008, 18:157-165.
25. Golozoubova V, Gullberg H, Matthias A, Cannon B, Vennstrom B, Nedergaard J. Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors. Mol Endocrinol 2004, 18:384-401.
26. Weiss RE, Refetoff S. Resistance to thyroid hormone. Rev Endocr Metab Disord 2000, 1:97-108.
27. Refetoff S, Weiss RE, Usala SJ. The syndromes of resistance to thyroid hormone. Endocr Rev 1993, 14:348-399.
28. Wikstrom L, Johansson C, Salto C, Barlow C, Campos BA, Baas F, Forrest D, Thoren P, Vennstrom B. Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1. EMBO J 1998, 17:455-461.
29. Kaneshige M, Kaneshige K, Zhu X, Dace A, Garrett L, Carter TA, Kazlauskaite R, Pankratz DG, Wynshaw-Boris A, Refetoff S, Weintraub B, Willingham MC, Barlow C, Cheng S. Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone. Proc Natl Acad Sci USA 2000, 97:13209-13214.
30. Liu YY, Schultz JJ, Brent GA. A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice. J Biol Chem 2003, 278:38913-38920.
31. Tinnikov A, Nordstrom K, Thoren P, Kindblom JM, Malin S, Rozell B, Adams M, Rajanayagam O, Pettersson S, Ohlsson C, Chatterjee K, Vennstrom B. Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1. EMBO J 2002, 21:5079-5087.
32. Kaneshige M, Suzuki H, Kaneshige K, Cheng J, Wimbrow H, Barlow C, Willingham MC, Cheng S. A targeted dominant negative mutation of the thyroid hormone alpha 1 receptor causes increased mortality, infertility, and dwarfism in mice. Proc Natl Acad Sci USA 2001, 98:15095-15100.
33. Quignodon L, Vincent S, Winter H, Samarut J, Flamant F. A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism. Mol Endocrinol 2007, 21:2350-2360.
34. Forrest D, Hanebuth E, Smeyne RJ, Everds N, Stewart CL, Wehner JM, Curran T. Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function. EMBO J 1996, 15:3006-3015.
35. Araki O, Ying H, Zhu XG, Willingham MC, Cheng SY. Distinct dysregulation of lipid metabolism by unliganded thyroid hormone receptor isoforms. Mol Endocrinol 2009, 23:308-315.
36. Ying H, Araki O, Furuya F, Kato Y, Cheng SY. Impaired adipogenesis caused by a mutated thyroid hormone alpha1 receptor. Mol Cell Biol 2007, 27:2359-2371.
37. Liu YY, Heymann RS, Moatamed F, Schultz JJ, Sobel D, Brent GA. A mutant thyroid hormone receptor alpha antagonizes peroxisome proliferator-activated receptor alpha signaling in vivo and impairs fatty acid oxidation. Endocrinology 2007, 148:1206-1217.
38. Venero C, Guadano-Ferraz A, Herrero AI, Nordstrom K, Manzano J, de Escobar GM, Bernal J, Vennstrom B. Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor alpha1 can be ameliorated by T3 treatment. Genes Dev 2005, 19:2152-2163.
39. Sjogren M, Alkemade A, Mittag J, Nordstrom K, Katz A, Rozell B, Westerblad H, Arner A, Vennstrom B. Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor alpha1. EMBO J 2007, 26:4535-4545.
40. Vujovic M, Nordstrom K, Gauthier K, Flamant F, Visser TJ, Vennstrom B, Mittag J. Interference of a mutant thyroid hormone receptor alpha1 with hepatic glucose metabolism. Endocrinology 2009, 150:2940-2947.
41. la Fleur SE, Kalsbeek A, Wortel J, Buijs RM. Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liver. Brain Res 2000, 871:50-56.
42. Kreier F, Fliers E, Voshol PJ, Van Eden CG, Havekes LM, Kalsbeek A, Van Heijningen CL, Sluiter AA, Mettenleiter TC, Romijn JA, Sauerwein HP, Buijs RM. Selective parasympathetic innervation of subcutaneous and intra-abdominal fat - functional implications. J Clin Invest 2002, 110:1243-1250.
43. Lechan RM, Qi Y, Jackson IM, Mahdavi V. Identification of thyroid hormone receptor isoforms in thyrotropin-releasing hormone neurons of the hypothalamic paraventricular nucleus. Endocrinology 1994, 135:92-100.
44. Zandieh-Doulabi B, Platvoet-ter SM, Kalsbeek A, Wiersinga WM, Bakker O. Hyper and hypothyroidism change the expression and diurnal variation of thyroid hormone receptor isoforms in rat liver without major changes in their zonal distribution. Mol Cell Endocrinol 2004, 219:69-75.
45. Zandieh DB, Platvoet-ter SM, Kalsbeek A, Fliers E, Bakker O, Wiersinga WM. Diurnal variation in rat liver thyroid hormone receptor (TR)-alpha messenger ribonucleic acid (mRNA) is dependent on the biological clock in the suprachiasmatic nucleus, whereas diurnal variation of TR beta 1 mRNA is modified by food intake. Endocrinology 2004, 145:1284-1289.
46. Zandieh DB, Platvoet-ter SM, Van Beeren HC, Labruyere WT, Lamers WH, Fliers E, Bakker O, Wiersinga WM. TR(beta)1 protein is preferentially expressed in the pericentral zone of rat liver and exhibits marked diurnal variation. Endocrinology 2002, 143:979-984.
47. Diano S, Naftolin F, Goglia F, Horvath TL. Fasting-induced increase in type II iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus. Endocrinology 1998, 139:2879-2884.
48. Fekete C, Gereben B, Doleschall M, Harney JW, Dora JM, Bianco AC, Sarkar S, Liposits Z, Rand W, Emerson C, Kacskovics I, Larsen PR, Lechan RM. Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology 2004, 145:1649-1655.
49. Fliers E, Guldenaar SE, Wiersinga WM, Swaab DF. Decreased hypothalamic thyrotropin-releasing hormone gene expression in patients with nonthyroidal illness. J Clin Endocrinol Metab 1997, 82:4032-4036.
50. Boelen A, Kwakkel J, Thijssen-Timmer DC, Alkemade A, Fliers E, Wiersinga WM. Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice. J Endocrinol 2004, 182:315-323.
51. Coppola A, Hughes J, Esposito E, Schiavo L, Meli R, Diano S. Suppression of hypothalamic deiodinase type II activity blunts TRH mRNA decline during fasting. FEBS Lett 2005, 579:4654-4658.
52. Kong WM, Martin NM, Smith KL, Gardiner JV, Connoley IP, Stephens DA, Dhillo WS, Ghatei MA, Small CJ, Bloom SR. Triiodothyronine stimulates food intake via the hypothalamic ventromedial nucleus independent of changes in energy expenditure. Endocrinology 2004, 145:5252-5258.
53. Klieverik LP, Janssen SF, van RA, Foppen E, Bisschop PH, Serlie MJ, Boelen A, Ackermans MT, Sauerwein HP, Fliers E, Kalsbeek A. Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. Proc Natl Acad Sci USA 2009, 106:5966-5971.
54. Klieverik LP, Sauerwein HP, Ackermans MT, Boelen A, Kalsbeek A, Fliers E. Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats. Am J Physiol Endocrinol Metab 2008, 294:E513-E520.