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Volumn 98, Issue 2, 1996, Pages 229-241

Comparison of the islet cell antibody pattern of monoclonal glutamic acid decarboxylase antibodies recognizing linear and conformational epitopes

Author keywords

65 kD isoform; cytoplasmic islet cell antibodies; diabetes mellitus; Dot blot; ELISA; epitope; glutamic acid decarboxylase; islet cells; monoclonal antibodies; pancreas

Indexed keywords

EPITOPE; GLUTAMATE DECARBOXYLASE; MONOCLONAL ANTIBODY;

EID: 0029982458     PISSN: 00651281     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0065-1281(96)80042-0     Document Type: Article
Times cited : (4)

References (39)
  • 1
    • 0027529913 scopus 로고
    • Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes
    • Atkinson MA, Kaufman DL, Newman D, Tobin AJ, and Maclaren NK (1993) Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes. J Clin Invest 91: 350-356
    • (1993) J Clin Invest , vol.91 , pp. 350-356
    • Atkinson, M.A.1    Kaufman, D.L.2    Newman, D.3    Tobin, A.J.4    Maclaren, N.K.5
  • 2
    • 0026678217 scopus 로고
    • Characterization of two porcine pro-insulin reactive monoclonal antibodies by immunostaining of β-cells in pancreatic sections of different species
    • Augstein P, Braun B, Ziegler B, Woltanski K-P, and Ziegler, M (1992) Characterization of two porcine pro-insulin reactive monoclonal antibodies by immunostaining of β-cells in pancreatic sections of different species. Acta histochem 93: 433-440
    • (1992) Acta Histochem , vol.93 , pp. 433-440
    • Augstein, P.1    Braun, B.2    Ziegler, B.3    Woltanski, K.-P.4    Ziegler, M.5
  • 3
    • 0019959221 scopus 로고
    • Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins
    • Baekkeskov S, Nielsen JH, Marner B, Bilde T, Ludvigsson J, and Lernmark A (1982) Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature (Lond) 298: 167-169
    • (1982) Nature (Lond) , vol.298 , pp. 167-169
    • Baekkeskov, S.1    Nielsen, J.H.2    Marner, B.3    Bilde, T.4    Ludvigsson, J.5    Lernmark, A.6
  • 5
    • 0028008978 scopus 로고
    • GAD autoantibodies in IDDM, Stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes
    • Björk E, Velloso LA, Kämpe O, and Karlsson AF (1994) GAD autoantibodies in IDDM, Stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes. Diabetes 43: 161-165
    • (1994) Diabetes , vol.43 , pp. 161-165
    • Björk, E.1    Velloso, L.A.2    Kämpe, O.3    Karlsson, A.F.4
  • 8
    • 0028673941 scopus 로고
    • Autoantibodies in insulin-dependent diabetes mellitus
    • Bosi E, and Bonifacio E (1994) Autoantibodies in insulin-dependent diabetes mellitus. J Endocrinol Invest 17: 521-531
    • (1994) J Endocrinol Invest , vol.17 , pp. 521-531
    • Bosi, E.1    Bonifacio, E.2
  • 9
    • 0016261369 scopus 로고
    • Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
    • Bottazzo GF, Florin-Christensen A, and Doniach D (1974) Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 2: 1279-1283
    • (1974) Lancet , vol.2 , pp. 1279-1283
    • Bottazzo, G.F.1    Florin-Christensen, A.2    Doniach, D.3
  • 10
    • 0018116131 scopus 로고
    • Islet cell antibodies (ICA) in diabetes mellitus: Evidence of an auto-antigen common to all the cells in the islet of Langerhans
    • Bottazzo GF, and Doniach D (1978) Islet cell antibodies (ICA) in diabetes mellitus: evidence of an auto-antigen common to all the cells in the islet of Langerhans. Ric Clin Lab 8: 29-38
    • (1978) Ric Clin Lab , vol.8 , pp. 29-38
    • Bottazzo, G.F.1    Doniach, D.2
  • 11
    • 0027489866 scopus 로고
    • Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in Stiff-man syndrome
    • Butler MH, Solimena M, Dirkx R, Haysay A, and De Camilli P (1993) Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in Stiff-man syndrome. J Exp Med 178: 2097-2106
    • (1993) J Exp Med , vol.178 , pp. 2097-2106
    • Butler, M.H.1    Solimena, M.2    Dirkx, R.3    Haysay, A.4    De Camilli, P.5
  • 12
    • 0028346078 scopus 로고
    • Combined analysis of islet cell antibodies which crossreact with mouse pancreas, antibodies to the Mr 64,000 islet protein, and antibodies to glutamate decarboxylase in subjects at risk for IDDM
    • Chaillous L, Delamaire M, Elmansour A, Maugendre D, Rohmer V, Joseph MG, Lecompte P, Limal JM, Charbonnel B, Allannic H, and Sai P (1994) Combined analysis of islet cell antibodies which crossreact with mouse pancreas, antibodies to the Mr 64,000 islet protein, and antibodies to glutamate decarboxylase in subjects at risk for IDDM. Diabetologia 37: 491-499
    • (1994) Diabetologia , vol.37 , pp. 491-499
    • Chaillous, L.1    Delamaire, M.2    Elmansour, A.3    Maugendre, D.4    Rohmer, V.5    Joseph, M.G.6    Lecompte, P.7    Limal, J.M.8    Charbonnel, B.9    Allannic, H.10    Sai, P.11
  • 19
    • 0016856843 scopus 로고
    • Islet-cell antibodies in juvenile diabetes mellitus of recent onset
    • Lendrum R, Walker G, and Gamble DR (1975) Islet-cell antibodies in juvenile diabetes mellitus of recent onset. Lancet 1: 880-882
    • (1975) Lancet , vol.1 , pp. 880-882
    • Lendrum, R.1    Walker, G.2    Gamble, D.R.3
  • 21
    • 0027030967 scopus 로고
    • Detection of antibodies against both isoforms of glutamate decarboxylase in BB/OK rats by Western blotting and immunotrapping enzyme activity assay
    • Lühder F, Woltanski KP, Hamann J, Klöting I, Ziegler B, and Ziegler M (1992) Detection of antibodies against both isoforms of glutamate decarboxylase in BB/OK rats by Western blotting and immunotrapping enzyme activity assay. Diab Res 20: 97-107
    • (1992) Diab Res , vol.20 , pp. 97-107
    • Lühder, F.1    Woltanski, K.P.2    Hamann, J.3    Klöting, I.4    Ziegler, B.5    Ziegler, M.6
  • 22
    • 0027340217 scopus 로고
    • Characterization of a linear epitope within the human pancreatic 64-kDa glutamic acid decarboxylase and its autoimmune recognition by sera from insulin-dependent diabetes mellitus
    • Mauch L, Abney CC, Berg H, Scherbaum WA, Liedvogel B, and Northemann W (1993) Characterization of a linear epitope within the human pancreatic 64-kDa glutamic acid decarboxylase and its autoimmune recognition by sera from insulin-dependent diabetes mellitus. Eur J Biochem 212: 597-603
    • (1993) Eur J Biochem , vol.212 , pp. 597-603
    • Mauch, L.1    Abney, C.C.2    Berg, H.3    Scherbaum, W.A.4    Liedvogel, B.5    Northemann, W.6
  • 23
    • 0021816281 scopus 로고
    • 'Cytoplasmic' islet cell antibodies. Evidence that the target antigen is a sialoglycoconjugate
    • Nayak RC, Omar MAK, Rabizadeh A, Srikanta S, and Eisenbarth GS (1985) 'Cytoplasmic' islet cell antibodies. Evidence that the target antigen is a sialoglycoconjugate. Diabetes 34: 617-619
    • (1985) Diabetes , vol.34 , pp. 617-619
    • Nayak, R.C.1    Omar, M.A.K.2    Rabizadeh, A.3    Srikanta, S.4    Eisenbarth, G.S.5
  • 24
    • 0028575726 scopus 로고
    • Glutamic acid decarboxylase (GAD65) autoantibodies in prediction of β-cell function and remission in recent-oncet IDDM after cyclosporin treatment
    • Petersen JS, Dyrberg T, Karlsen A, Karlsen AE, Molvig J, Michelsen B, Nerup J, Mandrup-Poulsen T, and the CERCTG (1994) Glutamic acid decarboxylase (GAD65) autoantibodies in prediction of β-cell function and remission in recent-oncet IDDM after cyclosporin treatment. Diabetes 43: 1291-1296
    • (1994) Diabetes , vol.43 , pp. 1291-1296
    • Petersen, J.S.1    Dyrberg, T.2    Karlsen, A.3    Karlsen, A.E.4    Molvig, J.5    Michelsen, B.6    Nerup, J.7    Mandrup-Poulsen, T.8    Cerctg, T.9
  • 26
    • 0027433010 scopus 로고
    • Cytoplasmic islet cell antibodies recognize distinct islet antigens in IDDM but not in Stiff man syndrome
    • Richter W, Seissler J, Northemann W, Wohlfahrt S, Meinck HM, and Scherbaum WA (1993b) Cytoplasmic islet cell antibodies recognize distinct islet antigens in IDDM but not in Stiff man syndrome. Diabetes 42: 1642-1648
    • (1993) Diabetes , vol.42 , pp. 1642-1648
    • Richter, W.1    Seissler, J.2    Northemann, W.3    Wohlfahrt, S.4    Meinck, H.M.5    Scherbaum, W.A.6
  • 27
    • 0027201695 scopus 로고
    • Quantification of human cytoplasmic islet-cell antibodies which cross-react with mouse pancreas: A follow-up study in Type 1 (insulin-dependent) diabetic patients and in first degree relatives
    • Sai P, Elmansour A, Audrain M, Charbonnel B, and Bardet S (1993) Quantification of human cytoplasmic islet-cell antibodies which cross-react with mouse pancreas: A follow-up study in Type 1 (insulin-dependent) diabetic patients and in first degree relatives. Diabetologia 36: 778-784
    • (1993) Diabetologia , vol.36 , pp. 778-784
    • Sai, P.1    Elmansour, A.2    Audrain, M.3    Charbonnel, B.4    Bardet, S.5
  • 28
    • 85030207254 scopus 로고
    • Sensitiver Sandwich-ELISA zur quantitativen Bestimmung von Glutamatdekarboxylase (GAD65) in pankreatischen Inseln und Organextrakten
    • Schlosser M, Hahmann J, Ziegler B, and Ziegler M (1995) Sensitiver Sandwich-ELISA zur quantitativen Bestimmung von Glutamatdekarboxylase (GAD65) in pankreatischen Inseln und Organextrakten. Diabetes und Stoffwechsel 4: 204A
    • (1995) Diabetes und Stoffwechsel , vol.4
    • Schlosser, M.1    Hahmann, J.2    Ziegler, B.3    Ziegler, M.4
  • 29
    • 0025892299 scopus 로고
    • Influence of target cell preparation on binding of monoclonal islet cell reactive antibodies (mc-ICRA) in cellular enzyme-linked immunosorbent assay (CELISA)
    • Schlosser M, Witt S, Ziegler B, and Ziegler M (1991) Influence of target cell preparation on binding of monoclonal islet cell reactive antibodies (mc-ICRA) in cellular enzyme-linked immunosorbent assay (CELISA). J Immunol Meth 140: 101-109
    • (1991) J Immunol Meth , vol.140 , pp. 101-109
    • Schlosser, M.1    Witt, S.2    Ziegler, B.3    Ziegler, M.4
  • 30
    • 0028673764 scopus 로고
    • GAD, diabetes, and Stiff-Man syndrome: Some progress and more questions
    • Solimena M, Butler MH, and De Camilli P (1994) GAD, diabetes, and Stiff-Man syndrome: Some progress and more questions. J Endocrinol Invest 17: 509-520
    • (1994) J Endocrinol Invest , vol.17 , pp. 509-520
    • Solimena, M.1    Butler, M.H.2    De Camilli, P.3
  • 31
    • 0025781922 scopus 로고
    • Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-man syndrome und insulin-dependent diabetes mellitus
    • Solimena M, and De Camilli P (1991) Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-man syndrome und insulin-dependent diabetes mellitus. Trends Neurosci 14: 452-457
    • (1991) Trends Neurosci , vol.14 , pp. 452-457
    • Solimena, M.1    De Camilli, P.2
  • 36
    • 0028132553 scopus 로고
    • Identification of glutamic acid decarboxylase autoantibody heterogeneity and epitope regions in type 1 diabetes
    • Ujihara N, Kendra D, Gianani R, Boel E, Liping Y, and Powers AC (1994) Identification of glutamic acid decarboxylase autoantibody heterogeneity and epitope regions in type 1 diabetes. Diabetes 43: 968-975
    • (1994) Diabetes , vol.43 , pp. 968-975
    • Ujihara, N.1    Kendra, D.2    Gianani, R.3    Boel, E.4    Liping, Y.5    Powers, A.C.6
  • 37
    • 0027311069 scopus 로고
    • Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression
    • Velloso LA, Kämpe O, Hallberg A, Christmanson L, Betsholtz C, and Karlsson EA (1993) Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression. J Clin Invest 91: 2084-2090
    • (1993) J Clin Invest , vol.91 , pp. 2084-2090
    • Velloso, L.A.1    Kämpe, O.2    Hallberg, A.3    Christmanson, L.4    Betsholtz, C.5    Karlsson, E.A.6
  • 38
    • 0028685980 scopus 로고
    • Monoclonal antibodies specific to glutamic acid decarboxylase 65 kDa isoform derived from non-obese diabetic (NOD) mouse
    • Ziegler B, Augstein P, Lühder F, Northemann W, Hamann J, Schlosser M, Kloting I, and Ziegler M (1994) Monoclonal antibodies specific to glutamic acid decarboxylase 65 kDa isoform derived from non-obese diabetic (NOD) mouse. Diab Res 25: 47-64
    • (1994) Diab Res , vol.25 , pp. 47-64
    • Ziegler, B.1    Augstein, P.2    Lühder, F.3    Northemann, W.4    Hamann, J.5    Schlosser, M.6    Kloting, I.7    Ziegler, M.8
  • 39
    • 0030033089 scopus 로고    scopus 로고
    • Glutamate decarboxylase (GAD) is not detectable on the surface of rat islet cells examined by cytofluorometry and complement-dependent antibody-mediated cytotoxicity of monoclonal GAD antibodies
    • Ziegler B, Augstein P, Schröder D, Mauch L, Hahmann J, Schlosser M, and Ziegler M (1996) Glutamate decarboxylase (GAD) is not detectable on the surface of rat islet cells examined by cytofluorometry and complement-dependent antibody-mediated cytotoxicity of monoclonal GAD antibodies. Horm Metab Res 28: 11-15
    • (1996) Horm Metab Res , vol.28 , pp. 11-15
    • Ziegler, B.1    Augstein, P.2    Schröder, D.3    Mauch, L.4    Hahmann, J.5    Schlosser, M.6    Ziegler, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.