17β-estradiol induces gastrointestinal motility disorder by decreasing CPI-17 phosphorylation via changes in Rho-family G-protein Rnd expression in small intestine

Journal of Veterinary Medical Science

Volumn 71, Issue 12, 2009, Pages 1591-1597

  Shimomura, Aya ^a   Ohama, Takashi ^a   Hori, Masatoshi ^a   Ozaki, Hiroshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Contraction; Estrogen; Gastrointestinal motility; Irritable bowel syndrome (IBS)

Indexed keywords

RATTUS;

CARBACHOL; ESTRADIOL; GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCLE PROTEIN; PHOSPHOPROTEIN; PPP1R14A PROTEIN, RAT;

ANIMAL; ARTICLE; DOSE RESPONSE; DRUG EFFECT; FEMALE; GASTROINTESTINAL MOTILITY; GENE EXPRESSION REGULATION; GENETICS; ILEUM; MALE; METABOLISM; MUSCLE CONTRACTION; OVARIECTOMY; PHOSPHORYLATION; PHYSIOLOGY; RAT; SMOOTH MUSCLE; TISSUE CULTURE TECHNIQUE; WISTAR RAT;

ANIMALS; CARBACHOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FEMALE; GASTROINTESTINAL MOTILITY; GENE EXPRESSION REGULATION; GTP-BINDING PROTEINS; ILEUM; MALE; MUSCLE CONTRACTION; MUSCLE PROTEINS; MUSCLE, SMOOTH; OVARIECTOMY; PHOSPHOPROTEINS; PHOSPHORYLATION; RATS; RATS, WISTAR; TISSUE CULTURE TECHNIQUES;

EID: 73349086258     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.001591     Document Type: Article

References (24)

1. Bruce, L.A. and Beshudi, F.M. 1981. Increased gastrointestinal motility in vitro following chronic estrogen treatment in male rats. Proc. Soc. Exp. Biol. Med. 166: 355-359.
2. 2+ sensitization of rabbit myometrium during pregnancy - role of Rnd3. J. Physiol. 552: 403-413.
3. Chang, L. and Heitkemper, M. M. 2002. Gender differences in irritable bowel syndrome. Gastroenterology 123: 1686-1701.
4. Chardin, P. 2003. GTPase regulation: getting aRnd Rock and Rho inhibition. Curr. Biol. 13: R702-704.
5. Diaz, M., Ramirez, C. M., Marin, R., Marrero-Alonso, J., Gomez, T. and Alonso, R. 2004. Acute relaxation of mouse duodenum by estrogens. Evidence for an estrogen receptorindependent modulation of muscle excitability. Eur. J. Pharmacol. 501: 161-178.
6. Drossman, D. A., Li, Z., Andruzzi, E., Temple, R. D., Talley, N. J., Thompson, W. G., Whitehead, W. E., Janssens, J., Funch-Jensen, P., Corazziari, E. and et al. 1993. U.S. house-holder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig. Dis. Sci. 38: 1569-1580.
7. Eto, M., Kitazawa, T. and Brautigan, D. L. 2004. Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits. Proc. Natl. Acad. Sci. U.S.A. 101: 8888-8893.
8. Gomez, M. and Sward, K. 1997. Long-term regulation of contractility and calcium current in smooth muscle. Am. J. Physiol. 273: C1714-1720.
9. Gustafsson, J. A. 1999. Estrogen receptor beta--a new dimension in estrogen mechanism of action. J. Endocrinol. 163: 379-383.
10. Hamaguchi, T., Ito, M., Feng, J., Seko, T., Koyama, M., Machida, H., Takase, K., Amano, M., Kaibuchi, K., Hartshorne, D. J. and Nakano, T. 2000. Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N. Biochem. Biophys. Res. Commun. 274: 825-830.
11. Heinemann, A., Pieber, D. and Holzer, P. 2002. Inhibition by female sex steroids of peristalsis in the guinea pig small intestine. Digestion 65: 213-219.
12. Horner, M. J., Ward, S. M., Gerthoffer, W. T., Sanders, K. M. and Horowitz, B. 1997. Maintenance of morphology and function of canine proximal colon smooth muscle in organ culture. Am. J. Physiol. 272: G669-680.
13. Kim, Y. S., Hori, M., Yasuda, K. and Ozaki, H. 2005. Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria. Comp. Biochem. Physiol. Part A 142: 410-415.
14. 2+ sensitization of contractile elements in rat myometrium. Biochem. Biophys. Res. Commun. 311: 972-978.
15. Kitazawa, T., Eto, M., Woodsome, T. P. and Brautigan, D. L. 2000. Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. J. Biol. Chem. 275: 9897-9900.
16. Li, L., Eto, M., Lee, M. R., Morita, F., Yazawa, M. and Kitazawa, T. 1998. Possible involvement of the novel CPI-17 protein in protein kinase C signal transduction of rabbit arterial smooth muscle. J. Physiol. 508: 871-881.
17. 2+ sensitization of rat smooth muscle. J. Physiol. 516: 825-834.
18. O'Lone, R., Frith, M. C., Karlsson, E.K. and Hansen, U. 2004. Genomic targets of nuclear estrogen receptors. Mol. Endocrinol. 18: 1859-1875.
19. Ohama, T., Hori, M., Momotani, E., Elorza, M., Gerthoffer, W. T. and Ozaki, H. 2007. IL-1β inhibits intestinal smooth muscle proliferation in an organ culture system: involvement of COX-2 and iNOS induction in muscularis resident macrophages. Am. J. Physiol. 292: G1315-1322.
20. Ohama, T., Hori, M., Sato, K., Ozaki, H. and Karaki, H. 2003. Chronic treatment with interleukin-1beta attenuates contractions by decreasing the activities of CPI-17 and MYPT-1 in intestinal smooth muscle. J. Biol. Chem. 278: 48794-48804.
21. Olden, K. W. 2002. Diagnosis of irritable bowel syndrome. Gastroenterology 122: 1701-1714.
22. Ozaki, H. and Karaki, H. 2002. Organ culture as a useful method for studying the biology of blood vessels and other smooth muscle tissues. Jpn. J. Pharmacol. 89: 93-100.
23. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol. Rev. 83: 1325-1358.
24. Wennerberg, K., Forget, M. A., Ellerbroek, S. M., Arthur, W.T., Burridge, K., Settleman, J., Der, C. J. and Hansen, S. H. 2003. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. Curr. Biol. 13: 1106-1115.