Anorectal Crohn's Disease

Surgical Clinics of North America

Volumn 90, Issue 1, 2010, Pages 83-97

  Lewis, Robert T ^a   Maron, David J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Abscess; Advancement flap; Crohn's; Fistula; Fistulotomy; Stricture

Indexed keywords

ADALIMUMAB; AZATHIOPRINE; CIPROFLOXACIN; CYCLOSPORIN; INFLIXIMAB; MERCAPTOPURINE; METRONIDAZOLE; PLACEBO; TACROLIMUS;

ABSCESS; ANORECTAL DISEASE; ANUS FISSURE; ANUS FISTULA; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CROHN DISEASE; DIAGNOSTIC ACCURACY; DIGITAL RECTAL EXAMINATION; DOSE RESPONSE; DRUG DOSAGE FORM COMPARISON; DRUG WITHDRAWAL; ENDOSCOPIC ECHOGRAPHY; FISTULOTOMY; HEMORRHOID; HUMAN; ILEOANAL ANASTOMOSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROCTOCOLECTOMY; RECTUM RESECTION; RECTUM ULCER; REVIEW; SEPSIS; SKIN FISSURE; SURGICAL TECHNIQUE;

ALGORITHMS; CONSTRICTION, PATHOLOGIC; CROHN DISEASE; FISSURE IN ANO; HEMORRHOIDS; HUMANS; PHYSICAL EXAMINATION; PROCTOCOLECTOMY, RESTORATIVE; RECTAL DISEASES; RECTAL FISTULA; RECTUM;

EID: 73249133815     PISSN: 00396109     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.suc.2009.09.004     Document Type: Review

References (144)

1. Crohn B.B., Ginzberg L., and Oppenheimer G.D. Regional ileitis: a pathologic and clinical entity. JAMA 99 (1932) 1323
2. Bissell A.D. Localized chronic ulcerative ileitis. Ann Surg 99 6 (1934) 957-966
3. Penner A., and Crohn B.B. Perianal fistulae as a complication of regional ileitis. Ann Surg 108 5 (1938) 867-873
4. Gabriel W.B. Results of an experimental and histological investigation in seventy-five cases of rectal fistulae. Proc R Soc Med 14 (1921) 156-161
5. Hellers G., Bergstrand O., Ewerth S., et al. Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease. Gut 21 6 (1980) 525-527
6. Sandborn W.J., Fazio V.W., Feagan B.G., et al. AGA technical review on perianal Crohn's disease. Gastroenterology 125 5 (2003) 1508-1530
7. Schwartz D.A., Loftus Jr. E.V., Tremaine W.J., et al. The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota. Gastroenterology 122 4 (2002) 875-880
8. Lockhart-Mummery H.E. Symposium. Crohn's disease: anal lesions. Dis Colon Rectum 18 3 (1975) 200-202
9. McClane S.J., and Rombeau J.L. Anorectal Crohn's disease. Surg Clin North Am 81 1 (2001) 169-183 ix
10. Williams D.R., Coller J.A., Corman M.L., et al. Anal complications in Crohn's disease. Dis Colon Rectum 24 1 (1981) 22-24
11. Gray B.K., Lockhart-Mummery H.E., and Morson B.C. Crohn's disease of the anal region. Gut 6 6 (1965) 515-524
12. Markowitz J., Daum F., Aiges H., et al. Perianal disease in children and adolescents with Crohn's disease. Gastroenterology 86 5 Pt 1 (1984) 829-833
13. Palder S.B., Shandling B., Bilik R., et al. Perianal complications of pediatric Crohn's disease. J Pediatr Surg 26 5 (1991) 513-515
14. Cosnes J., Cattan S., Blain A., et al. Long-term evolution of disease behavior of Crohn's disease. Inflamm Bowel Dis 8 4 (2002) 244-250
15. Roberts P.L., Schoetz Jr. D.J., Pricolo R., et al. Clinical course of Crohn's disease in older patients. A retrospective study. Dis Colon Rectum 33 6 (1990) 458-462
16. Nguyen G.C., Torres E.A., Regueiro M., et al. Inflammatory bowel disease characteristics among African Americans, Hispanics, and non-Hispanic Whites: characterization of a large North American cohort. Am J Gastroenterol 101 5 (2006) 1012-1023
17. Cross R.K., Jung C., Wasan S., et al. Racial differences in disease phenotypes in patients with Crohn's disease. Inflamm Bowel Dis 12 3 (2006) 192-198
18. Beaugerie L., Seksik P., Nion-Larmurier I., et al. Predictors of Crohn's disease. Gastroenterology 130 3 (2006) 650-656
19. Rankin G.B., Watts H.D., Melnyk C.S., et al. National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications. Gastroenterology 77 4 Pt 2 (1979) 914-920
20. Gelbmann C.M., Rogler G., Gross V., et al. Prior bowel resections, perianal disease, and a high initial Crohn's disease activity index are associated with corticosteroid resistance in active Crohn's disease. Am J Gastroenterol 97 6 (2002) 1438-1445
21. Makowiec F., Jehle E.C., and Starlinger M. Clinical course of perianal fistulas in Crohn's disease. Gut 37 5 (1995) 696-701
22. Mahmoud N., Rombeau J.L., Ross H.M., et al. Colon and rectum. PA. In: Townsend C.M., Beauchamp R.D., Evers B.M., et al. (Eds) (2004), Saunders, Sabiston Textbook of Surgery. Philadelphia 1401
23. Gillen C.D., Walmsley R.S., Prior P., et al. Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis. Gut 35 11 (1994) 1590-1592
24. Ekbom A., Helmick C., Zack M., et al. Increased risk of large-bowel cancer in Crohn's disease with colonic involvement. Lancet 336 8711 (1990) 357-359
25. Sjodahl R.I., Myrelid P., and Soderholm J.D. Anal and rectal cancer in Crohn's disease. Colorectal Dis 5 5 (2003) 490-495
26. Ky A., Sohn N., Weinstein M.A., et al. Carcinoma arising in anorectal fistulas of Crohn's disease. Dis Colon Rectum 41 8 (1998) 992-996
27. Connell W.R., Sheffield J.P., Kamm M.A., et al. Lower gastrointestinal malignancy in Crohn's disease. Gut 35 3 (1994) 347-352
28. Weedon D.D., Shorter R.G., Ilstrup D.M., et al. Crohn's disease and cancer. N Engl J Med 289 21 (1973) 1099-1103
29. Vermeire S., Van Assche G., and Rutgeerts P. Perianal Crohn's disease: classification and clinical evaluation. Dig Liver Dis 39 10 (2007) 959-962
30. Keighley M.R., and Allan R.N. Current status and influence of operation on perianal Crohn's disease. Int J Colorectal Dis 1 2 (1986) 104-107
31. Buchmann P., Keighley M.R., Allan R.N., et al. Natural history of perianal Crohn's disease. Ten year follow-up: a plea for conservatism. Am J Surg 140 5 (1980) 642-644
32. Ingle S.B., and Loftus Jr. E.V. The natural history of perianal Crohn's disease. Dig Liver Dis 39 10 (2007) 963-969
33. Wolkomir A.F., and Luchtefeld M.A. Surgery for symptomatic hemorrhoids and anal fissures in Crohn's disease. Dis Colon Rectum 36 6 (1993) 545-547
34. Steele S.R. Operative management of Crohn's disease of the colon including anorectal disease. Surg Clin North Am 87 3 (2007) 611-631
35. Singh B., McC Mortensen N.J., Jewell D.P., et al. Perianal Crohn's disease. Br J Surg 91 7 (2004) 801-814
36. Nelson R.L., Abcarian H., Davis F.G., et al. Prevalence of benign anorectal disease in a randomly selected population. Dis Colon Rectum 38 4 (1995) 341-344
37. Jeffery P.J., Parks A.G., and Ritchie J.K. Treatment of haemorrhoids in patients with inflammatory bowel disease. Lancet 1 8021 (1977) 1084-1085
38. Sweeney J.L., Ritchie J.K., and Nicholls R.J. Anal fissure in Crohn's disease. Br J Surg 75 1 (1988) 56-57
39. Fleshner P.R., Schoetz Jr. D.J., Roberts P.L., et al. Anal fissure in Crohn's disease: a plea for aggressive management. Dis Colon Rectum 38 11 (1995) 1137-1143
40. Madoff R.D., and Fleshman J.W. AGA technical review on the diagnosis and care of patients with anal fissure. Gastroenterology 124 1 (2003) 235-245
41. Singh B., George B.D., and Mortensen N.J. Surgical therapy of perianal Crohn's disease. Dig Liver Dis 39 10 (2007) 988-992
42. Siproudhis L., Mortaji A., Mary J.Y., et al. Anal lesions: any significant prognosis in Crohn's disease?. Eur J Gastroenterol Hepatol 9 3 (1997) 239-243
43. Strong S.A. Perianal Crohn's disease. Semin Pediatr Surg 16 3 (2007) 185-193
44. Linares L., Moreira L.F., Andrews H., et al. Natural history and treatment of anorectal strictures complicating Crohn's disease. Br J Surg 75 7 (1988) 653-655
45. Alexander-Williams J., Allan A., Morel P., et al. The therapeutic dilatation of enteric strictures due to Crohn's disease. Ann R Coll Surg Engl 68 2 (1986) 95-97
46. Galandiuk S., Kimberling J., Al-Mishlab T.G., et al. Perianal Crohn's disease: predictors of need for permanent diversion. Ann Surg 241 5 (2005) 796-801 [discussion: 801-2]
47. Williamson M.E., and Hughes L.E. Bowel diversion should be used with caution in stenosing anal Crohn's disease. Gut 35 8 (1994) 1139-1140
48. Regueiro M., and Mardini H. Treatment of perianal fistulizing Crohn's disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement. Inflamm Bowel Dis 9 2 (2003) 98-103
49. Topstad D.R., Panaccione R., Heine J.A., et al. Combined seton placement, infliximab infusion, and maintenance immunosuppressives improve healing rate in fistulizing anorectal Crohn's disease: a single center experience. Dis Colon Rectum 46 5 (2003) 577-583
50. Schwartz D.A., White C.M., Wise P.E., et al. Use of endoscopic ultrasound to guide combination medical and surgical therapy for patients with Crohn's perianal fistulas. Inflamm Bowel Dis 11 8 (2005) 727-732
51. Schwartz D.A., Wiersema M.J., Dudiak K.M., et al. A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn's perianal fistulas. Gastroenterology 121 5 (2001) 1064-1072
52. Kuijpers H.C., and Schulpen T. Fistulography for fistula-in-ano. Is it useful?. Dis Colon Rectum 28 2 (1985) 103-104
53. Weisman R.I., Orsay C.P., Pearl R.K., et al. The role of fistulography in fistula-in-ano. Report of five cases. Dis Colon Rectum 34 2 (1991) 181-184
54. Yousem D.M., Fishman E.K., and Jones B. Crohn disease: perirectal and perianal findings at CT. Radiology 167 2 (1988) 331-334
55. Schratter-Sehn A.U., Lochs H., Vogelsang H., et al. Endoscopic ultrasonography versus computed tomography in the differential diagnosis of perianorectal complications in Crohn's disease. Endoscopy 25 9 (1993) 582-586
56. Buchanan G.N., Halligan S., Bartram C.I., et al. Clinical examination, endosonography, and MR imaging in preoperative assessment of fistula in ano: comparison with outcome-based reference standard. Radiology 233 3 (2004) 674-681
57. Lunniss P.J., Barker P.G., Sultan A.H., et al. Magnetic resonance imaging of fistula-in-ano. Dis Colon Rectum 37 7 (1994) 708-718
58. West R.L., Dwarkasing S., Felt-Bersma R.J., et al. Hydrogen peroxide-enhanced three-dimensional endoanal ultrasonography and endoanal magnetic resonance imaging in evaluating perianal fistulas: agreement and patient preference. Eur J Gastroenterol Hepatol 16 12 (2004) 1319-1324
59. West R.L., Zimmerman D.D., Dwarkasing S., et al. Prospective comparison of hydrogen peroxide-enhanced three-dimensional endoanal ultrasonography and endoanal magnetic resonance imaging of perianal fistulas. Dis Colon Rectum 46 10 (2003) 1407-1415
60. Poen A.C., Felt-Bersma R.J., Eijsbouts Q.A., et al. Hydrogen peroxide-enhanced transanal ultrasound in the assessment of fistula-in-ano. Dis Colon Rectum 41 9 (1998) 1147-1152
61. Ardizzone S., Maconi G., Colombo E., et al. Perianal fistulae following infliximab treatment: clinical and endosonographic outcome. Inflamm Bowel Dis 10 2 (2004) 91-96
62. Spradlin N.M., Wise P.E., Herline A.J., et al. A randomized prospective trial of endoscopic ultrasound to guide combination medical and surgical treatment for Crohn's perianal fistulas. Am J Gastroenterol 103 10 (2008) 2527-2535
63. Schaefer O., Lohrmann C., and Langer M. Assessment of anal fistulas with high-resolution subtraction MR-fistulography: comparison with surgical findings. J Magn Reson Imaging 19 1 (2004) 91-98
64. Beets-Tan R.G., Beets G.L., van der Hoop A.G., et al. Preoperative MR imaging of anal fistulas: does it really help the surgeon?. Radiology 218 1 (2001) 75-84
65. Buchanan G.N., Halligan S., Williams A.B., et al. Magnetic resonance imaging for primary fistula in ano. Br J Surg 90 7 (2003) 877-881
66. Sachar D.B., Bodian C.A., Goldstein E.S., et al. Is perianal Crohn's disease associated with intestinal fistulization?. Am J Gastroenterol 100 7 (2005) 1547-1549
67. Heuman R., Bolin T., Sjodahl R., et al. The incidence and course of perianal complications and arthralgia after intestinal resection with restoration of continuity for Crohn's disease. Br J Surg 68 8 (1981) 528-530
68. Marks C.G., Ritchie J.K., and Lockhart-Mummery H.E. Anal fistulas in Crohn's disease. Br J Surg 68 8 (1981) 525-527
69. Orkin B.A., and Telander R.L. The effect of intra-abdominal resection or fecal diversion on perianal disease in pediatric Crohn's disease. J Pediatr Surg 20 4 (1985) 343-347
70. Pritchard T.J., Schoetz Jr. D.J., Roberts P.L., et al. Perirectal abscess in Crohn's disease. Drainage and outcome. Dis Colon Rectum 33 11 (1990) 933-937
71. Sohn N., Korelitz B.I., and Weinstein M.A. Anorectal Crohn's disease: definitive surgery for fistulas and recurrent abscesses. Am J Surg 139 3 (1980) 394-397
72. Giovannini M., Bories E., Moutardier V., et al. Drainage of deep pelvic abscesses using therapeutic echo endoscopy. Endoscopy 35 6 (2003) 511-514
73. Williams J.G., Rothenberger D.A., Nemer F.D., et al. Fistula-in-ano in Crohn's disease. Results of aggressive surgical treatment. Dis Colon Rectum 34 5 (1991) 378-384
74. Halme L., and Sainio A.P. Factors related to frequency, type, and outcome of anal fistulas in Crohn's disease. Dis Colon Rectum 38 1 (1995) 55-59
75. Sangwan Y.P., Schoetz Jr. D.J., Murray J.J., et al. Perianal Crohn's disease. Results of local surgical treatment. Dis Colon Rectum 39 5 (1996) 529-535
76. Faucheron J.L., Saint-Marc O., Guibert L., et al. Long-term seton drainage for high anal fistulas in Crohn's disease-a sphincter-saving operation?. Dis Colon Rectum 39 2 (1996) 208-211
77. Pearl R.K., Andrews J.R., Orsay C.P., et al. Role of the seton in the management of anorectal fistulas. Dis Colon Rectum 36 6 (1993) 573-577 [discussion: 577-9]
78. Thornton M., and Solomon M.J. Long-term indwelling seton for complex anal fistulas in Crohn's disease. Dis Colon Rectum 48 3 (2005) 459-463
79. Buchanan G.N., Owen H.A., Torkington J., et al. Long-term outcome following loose-seton technique for external sphincter preservation in complex anal fistula. Br J Surg 91 4 (2004) 476-480
80. Eitan A., Koliada M., and Bickel A. The use of the loose seton technique as a definitive treatment for recurrent and persistent high trans-sphincteric anal fistulas: a long-term outcome. J Gastrointest Surg 13 6 (2009) 1116-1119
81. Edwards C.M., George B.D., Jewell D.P., et al. Role of a defunctioning stoma in the management of large bowel Crohn's disease. Br J Surg 87 8 (2000) 1063-1066
82. Dejaco C., Harrer M., Waldhoer T., et al. Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease. Aliment Pharmacol Ther 18 11-12 (2003) 1113-1120
83. Bernstein L.H., Frank M.S., Brandt L.J., et al. Healing of perineal Crohn's disease with metronidazole. Gastroenterology 79 3 (1980) 599
84. Turunen U.M., Farkkila M.A., Hakala K., et al. Long-term treatment of ulcerative colitis with ciprofloxacin: a prospective, double-blind, placebo-controlled study. Gastroenterology 115 5 (1998) 1072-1078
85. Brandt L.J., Bernstein L.H., Boley S.J., et al. Metronidazole therapy for perineal Crohn's disease: a follow-up study. Gastroenterology 83 2 (1982) 383-387
86. Jakobovits J., and Schuster M.M. Metronidazole therapy for Crohn's disease and associated fistulae. Am J Gastroenterol 79 7 (1984) 533-540
87. Pearson D.C., May G.R., Fick G.H., et al. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. Ann Intern Med 123 2 (1995) 132-142
88. Hinterleitner T.A., Petritsch W., Aichbichler B., et al. Combination of cyclosporine, azathioprine and prednisolone for perianal fistulas in Crohn's disease. Z Gastroenterol 35 8 (1997) 603-608
89. Egan L.J., Sandborn W.J., and Tremaine W.J. Clinical outcome following treatment of refractory inflammatory and fistulizing Crohn's disease with intravenous cyclosporine. Am J Gastroenterol 93 3 (1998) 442-448
90. Gurudu S.R., Griffel L.H., Gialanella R.J., et al. Cyclosporine therapy in inflammatory bowel disease: short-term and long-term results. J Clin Gastroenterol 29 2 (1999) 151-154
91. Sandborn W.J., Present D.H., Isaacs K.L., et al. Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial. Gastroenterology 125 2 (2003) 380-388
92. Present D.H., Rutgeerts P., Targan S., et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 340 18 (1999) 1398-1405
93. Sands B.E., Anderson F.H., Bernstein C.N., et al. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med 350 9 (2004) 876-885
94. Parsi M.A., Lashner B.A., Achkar J.P., et al. Type of fistula determines response to infliximab in patients with fistulous Crohn's disease. Am J Gastroenterol 99 3 (2004) 445-449
95. Ricart E., Panaccione R., Loftus E.V., et al. Infliximab for Crohn's disease in clinical practice at the Mayo Clinic: the first 100 patients. Am J Gastroenterol 96 3 (2001) 722-729
96. Schiff M.H., Burmester G.R., Kent J.D., et al. Safety analyses of adalimumab (HUMIRA) in global clinical trials and US postmarketing surveillance of patients with rheumatoid arthritis. Ann Rheum Dis 65 7 (2006) 889-894
97. Colombel J.F., Sandborn W.J., Rutgeerts P., et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology 132 1 (2007) 52-65
98. Colombel J.F., Schwartz D.A., Sandborn W.J., et al. Adalimumab for the treatment of fistulas in patients with Crohn's disease. Gut 58 7 (2009) 940-948
99. Hobbiss J.H., and Schofield P.F. Management of perianal Crohn's disease. J R Soc Med 75 6 (1982) 414-417
100. Morrison J.G., Gathright Jr. J.B., Ray J.E., et al. Surgical management of anorectal fistulas in Crohn's disease. Dis Colon Rectum 32 6 (1989) 492-496
101. Nordgren S., Fasth S., and Hulten L. Anal fistulas in Crohn's disease: incidence and outcome of surgical treatment. Int J Colorectal Dis 7 4 (1992) 214-218
102. Alexander-Williams J., Steinberg D.M., Fielding J.S., et al. Proceedings. Perianal Crohn's disease. Gut 15 10 (1974) 822-823
103. Lindsey I., Smilgin-Humphreys M.M., Cunningham C., et al. A randomized, controlled trial of fibrin glue vs. conventional treatment for anal fistula. Dis Colon Rectum 45 12 (2002) 1608-1615
104. Swinscoe M.T., Ventakasubramaniam A.K., and Jayne D.G. Fibrin glue for fistula-in-ano: the evidence reviewed. Tech Coloproctol 9 2 (2005) 89-94
105. Vitton V., Gasmi M., Barthet M., et al. Long-term healing of Crohn's anal fistulas with fibrin glue injection. Aliment Pharmacol Ther 21 12 (2005) 1453-1457
106. Loungnarath R., Dietz D.W., Mutch M.G., et al. Fibrin glue treatment of complex anal fistulas has low success rate. Dis Colon Rectum 47 4 (2004) 432-436
107. O'Connor L., Champagne B.J., Ferguson M.A., et al. Efficacy of anal fistula plug in closure of Crohn's anorectal fistulas. Dis Colon Rectum 49 10 (2006) 1569-1573
108. Champagne B.J., O'Connor L.M., Ferguson M., et al. Efficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-up. Dis Colon Rectum 49 12 (2006) 1817-1821
109. Ky A.J., Sylla P., Steinhagen R., et al. Collagen fistula plug for the treatment of anal fistulas. Dis Colon Rectum 51 6 (2008) 838-843
110. Talbot C., Sagar P.M., Johnston M.J., et al. Infliximab in the surgical management of complex fistulating anal Crohn's disease. Colorectal Dis 7 2 (2005) 164-168
111. Matos D., Lunniss P.J., and Phillips R.K. Total sphincter conservation in high fistula in ano: results of a new approach. Br J Surg 80 6 (1993) 802-804
112. Galis-Rozen E., Tulchinsky H., Rosen A., et al. Long-term outcome of loose-seton for complex anal fistula: a two-centre study of patients with and without Crohn's disease. Colorectal Dis (2009) [Epub ahed of print]
113. Makowiec F., Jehle E.C., Becker H.D., et al. Clinical course after transanal advancement flap repair of perianal fistula in patients with Crohn's disease. Br J Surg 82 5 (1995) 603-606
114. Joo J.S., Weiss E.G., Nogueras J.J., et al. Endorectal advancement flap in perianal Crohn's disease. Am Surg 64 2 (1998) 147-150
115. Robertson W.G., and Mangione J.S. Cutaneous advancement flap closure: alternative method for treatment of complicated anal fistulas. Dis Colon Rectum 41 7 (1998) 884-886 [discussion: 886-7]
116. Marchesa P., Hull T.L., and Fazio V.W. Advancement sleeve flaps for treatment of severe perianal Crohn's disease. Br J Surg 85 12 (1998) 1695-1698
117. van der Hagen S.J., Baeten C.G., Soeters P.B., et al. Anti-TNF-alpha (infliximab) used as induction treatment in case of active proctitis in a multistep strategy followed by definitive surgery of complex anal fistulas in Crohn's disease: a preliminary report. Dis Colon Rectum 48 4 (2005) 758-767
118. Gaertner W.B., Decanini A., Mellgren A., et al. Does infliximab infusion impact results of operative treatment for Crohn's perianal fistulas?. Dis Colon Rectum 50 11 (2007) 1754-1760
119. Andreani S.M., Dang H.H., Grondona P., et al. Rectovaginal fistula in Crohn's disease. Dis Colon Rectum 50 12 (2007) 2215-2222
120. Sands B.E., Blank M.A., Patel K., et al. Long-term treatment of rectovaginal fistulas in Crohn's disease: response to infliximab in the ACCENT II Study. Clin Gastroenterol Hepatol 2 10 (2004) 912-920
121. Hull T.L., and Fazio V.W. Surgical approaches to low anovaginal fistula in Crohn's disease. Am J Surg 173 2 (1997) 95-98
122. Kodner I.J., Mazor A., Shemesh E.I., et al. Endorectal advancement flap repair of rectovaginal and other complicated anorectal fistulas. Surgery 114 4 (1993) 682-689 [discussion: 689-90]
123. Berman I.R. Sleeve advancement anorectoplasty for complicated anorectal/vaginal fistula. Dis Colon Rectum 34 11 (1991) 1032-1037
124. Sher M.E., Bauer J.J., and Gelernt I. Surgical repair of rectovaginal fistulas in patients with Crohn's disease: transvaginal approach. Dis Colon Rectum 34 8 (1991) 641-648
125. Cohen J.L., Stricker J.W., Schoetz Jr. D.J., et al. Rectovaginal fistula in Crohn's disease. Dis Colon Rectum 32 10 (1989) 825-828
126. Yamamoto T., Bain I.M., Allan R.N., et al. Persistent perineal sinus after proctocolectomy for Crohn's disease. Dis Colon Rectum 42 1 (1999) 96-101
127. Rius J., Nessim A., Nogueras J.J., et al. Gracilis transposition in complicated perianal fistula and unhealed perineal wounds in Crohn's disease. Eur J Surg 166 3 (2000) 218-222
128. Yamamoto T., Allan R.N., and Keighley M.R. Effect of fecal diversion alone on perianal Crohn's disease. World J Surg 24 10 (2000) 1258-1262 [discussion: 1262-3]
129. Bach S.P., and Mortensen N.J. Revolution and evolution: 30 years of ileoanal pouch surgery. Inflamm Bowel Dis 12 2 (2006) 131-145
130. Sagar P.M., Dozois R.R., and Wolff B.G. Long-term results of ileal pouch-anal anastomosis in patients with Crohn's disease. Dis Colon Rectum 39 8 (1996) 893-898
131. Reese G.E., Lovegrove R.E., Tilney H.S., et al. The effect of Crohn's disease on outcomes after restorative proctocolectomy. Dis Colon Rectum 50 2 (2007) 239-250
132. Peyregne V., Francois Y., Gilly F.N., et al. Outcome of ileal pouch after secondary diagnosis of Crohn's disease. Int J Colorectal Dis 15 1 (2000) 49-53
133. Fazio V.W., Tekkis P.P., Remzi F., et al. Quantification of risk for pouch failure after ileal pouch anal anastomosis surgery. Ann Surg 238 4 (2003) 605-614 [discussion: 614-7]
134. MacRae H.M., McLeod R.S., Cohen Z., et al. Risk factors for pelvic pouch failure. Dis Colon Rectum 40 3 (1997) 257-262
135. Melmed G.Y., Fleshner P.R., Bardakcioglu O., et al. Family history and serology predict Crohn's disease after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum 51 1 (2008) 100-108
136. Alexander F., Sarigol S., DiFiore J., et al. Fate of the pouch in 151 pediatric patients after ileal pouch anal anastomosis. J Pediatr Surg 38 1 (2003) 78-82
137. Keswani R.N., and Cohen R.D. Postoperative management of ulcerative colitis and Crohn's disease. Curr Gastroenterol Rep 7 6 (2005) 492-499
138. Shen B., Remzi F.H., Brzezinski A., et al. Risk factors for pouch failure in patients with different phenotypes of Crohn's disease of the pouch. Inflamm Bowel Dis 14 7 (2008) 942-948
139. Wolf J.M., Achkar J., Lashner B.A., et al. Afferent limb ulcers predict Crohn's disease in patients with ileal pouch-anal anastomosis. Gastroenterology 126 7 (2004) 1686-1691
140. Viscido A., Habib F.I., Kohn A., et al. Infliximab in refractory pouchitis complicated by fistulae following ileo-anal pouch for ulcerative colitis. Aliment Pharmacol Ther 17 10 (2003) 1263-1271
141. Berrebi W., Chaussade S., Bruhl A.L., et al. Treatment of Crohn's disease recurrence after ileoanal anastomosis by azathioprine. Dig Dis Sci 38 8 (1993) 1558-1560
142. Colombel J.F., Ricart E., Loftus Jr. E.V., et al. Management of Crohn's disease of the ileoanal pouch with infliximab. Am J Gastroenterol 98 10 (2003) 2239-2244
143. Ozuner G., Hull T., Lee P., et al. What happens to a pelvic pouch when a fistula develops?. Dis Colon Rectum 40 5 (1997) 543-547
144. Alexander F. Complications of ileal pouch anal anastomosis. Semin Pediatr Surg 16 3 (2007) 200-204