Substrate specificity of SIRT1-catalyzed lysine Nε-deacetylation reaction probed with the side chain modified Nε-acetyl-lysine analogs

Bioorganic Chemistry

Volumn 38, Issue 1, 2010, Pages 17-25

  Jamonnak, Nuttara ^a   Hirsch, Brett M ^a   Pang, Yi ^a   Zheng, Weiping ^a  

^a UNIVERSITY OF AKRON   (United States)

Author keywords

Analogs; N acetyl lysine; Protein deacetylation; SIRT1

Indexed keywords

3 BROMOPROPIONAMIDE; CARBON; HOMOCYSTEINE; HOMOSERINE; LYSINE DERIVATIVE; N EPSILON ACETYLLYSINE DERIVATIVE; PROPIONAMIDE DERIVATIVE; SILENT INFORMATION REGULATOR PROTEIN 2; SIRTUIN 1; UNCLASSIFIED DRUG;

ARTICLE; DEACETYLATION; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SPECIFICITY; ESCHERICHIA COLI; HUMAN; MOLECULAR MODEL; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEREOSPECIFICITY;

BIOCATALYSIS; HUMANS; LYSINE; RECOMBINANT PROTEINS; SIRTUIN 1; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 73249132347     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2009.10.001     Document Type: Article

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