Quantitative profiling of in vivo generated cisplatin-DNA adducts using different isotope dilution strategies

Analytical Chemistry

Volumn 81, Issue 23, 2009, Pages 9553-9560

  Garcia Sar D ^a   Montes Bayon M ^a   Blanco Gonzalez E ^a   Sierra, L M ^a   Aguado, L ^a   Comendador, M A ^a   Koellensperger, G ^b   Hann, S ^b   Sanz Medel, A ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL RESULTS; ANALYTICAL TOOL; APOPTOSIS; BEFORE AND AFTER; CARCINOMA CELLS; CHEMOTHERAPEUTIC DRUGS; CIS-PLATIN; CURRENT PRACTICES; DNA ADDUCTS; DNA SAMPLES; ENZYMATIC DIGESTIONS; ENZYMATIC TREATMENTS; HEAD-AND-NECK SQUAMOUS CELL CARCINOMA; IN-VIVO; ISOTOPE DILUTION ANALYSIS; ISOTOPE DILUTIONS; ISOTOPICALLY ENRICHED; MASS SPECTROMETRIC DETECTION; POSTCOLUMN ADDITION; RELATIVE CONTRIBUTION; SYNTHESIS AND CHARACTERIZATION;

CELL CULTURE; CELL DEATH; CHROMATOGRAPHIC ANALYSIS; DNA; DRUG PRODUCTS; GENES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; INDUCTIVELY COUPLED PLASMA; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; ISOTOPES; MASS SPECTROMETERS; METAL RECOVERY; OLIGONUCLEOTIDES; PLATINUM; PLATINUM COMPOUNDS; SYNTHESIS (CHEMICAL); TRANSITION METAL COMPOUNDS;

ENZYMATIC HYDROLYSIS;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CISPLATIN; DNA ADDUCTS; DROSOPHILA MELANOGASTER; HUMANS; INDICATOR DILUTION TECHNIQUES; ISOTOPES; MASS SPECTROMETRY; OLIGODEOXYRIBONUCLEOTIDES;

EID: 73249120887     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac901360f     Document Type: Article

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