-
1
-
-
0030667522
-
Atm selectively regulates distinct TP53-dependent cell-cycle checkpoint and apoptotic pathways
-
Barlow C, Brown KD, Deng CX, Tagle DA, Wynshaw-Boris A. 1997. Atm selectively regulates distinct TP53-dependent cell-cycle checkpoint and apoptotic pathways. Nat Genet 17:453-456.
-
(1997)
Nat Genet
, vol.17
, pp. 453-456
-
-
Barlow, C.1
Brown, K.D.2
Deng, C.X.3
Tagle, D.A.4
Wynshaw-Boris, A.5
-
2
-
-
31544457877
-
TP53 ubiquitination. MDM2 and beyond
-
Brooks CL, Gu W. 2006. TP53 ubiquitination. MDM2 and beyond. Mol Cell 21:307-315.
-
(2006)
Mol Cell
, vol.21
, pp. 307-315
-
-
Brooks, C.L.1
Gu, W.2
-
3
-
-
0346690270
-
-
Chavez-Reyes A, Parant JM, Amelse LL, Montes de Oca Luna R, Korsmeye SJ, Lozano G. 2003. Switching mechanisms of cell death in MDM2- and MDM4-null mice by deletion of TP53 downstream targets. Cancer Res 63:8664-8669.
-
Chavez-Reyes A, Parant JM, Amelse LL, Montes de Oca Luna R, Korsmeye SJ, Lozano G. 2003. Switching mechanisms of cell death in MDM2- and MDM4-null mice by deletion of TP53 downstream targets. Cancer Res 63:8664-8669.
-
-
-
-
4
-
-
2942738959
-
Amplification of Mdmx (or MDM4) directly contributes to tumor formation by inhibiting TP53 tumor suppressor activity
-
Danovi D, Meulmeester E, Pasini D, Migliorini D, Capra M, Frenk R, de Graaf P, Francoz S, Gasparini P, Gobbi A, Helin K, Pelicci PG, Jochemsen AG, Marine JC. 2004. Amplification of Mdmx (or MDM4) directly contributes to tumor formation by inhibiting TP53 tumor suppressor activity. Mol Cell Biol 24:5835-5843.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5835-5843
-
-
Danovi, D.1
Meulmeester, E.2
Pasini, D.3
Migliorini, D.4
Capra, M.5
Frenk, R.6
de Graaf, P.7
Francoz, S.8
Gasparini, P.9
Gobbi, A.10
Helin, K.11
Pelicci, P.G.12
Jochemsen, A.G.13
Marine, J.C.14
-
5
-
-
0027359827
-
WAF1 a potential mediator of TP53 tumor suppression
-
El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. 1993. WAF1 a potential mediator of TP53 tumor suppression. Cell 75:817-825.
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
El-Deiry, W.S.1
Tokino, T.2
Velculescu, V.E.3
Levy, D.B.4
Parsons, R.5
Trent, J.M.6
Lin, D.7
Mercer, W.E.8
Kinzler, K.W.9
Vogelstein, B.10
-
6
-
-
33644778697
-
MDM4 and MDM2 cooperated to inhibit TP53 activity in proliferating and quiescent cells in vivo
-
Francoz S, Froment P, Bogaerts S, De Clerq S, Maetens M, Doumont G, Bellefroid E, Marine JC. 2006. MDM4 and MDM2 cooperated to inhibit TP53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci USA 103:3232-3237.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3232-3237
-
-
Francoz, S.1
Froment, P.2
Bogaerts, S.3
De Clerq, S.4
Maetens, M.5
Doumont, G.6
Bellefroid, E.7
Marine, J.C.8
-
8
-
-
27844452053
-
CDKN1A in cells surviving UV-irradiation
-
CDKN1A in cells surviving UV-irradiation. DNA Repair 4:1457-1462.
-
(2005)
DNA Repair
, vol.4
, pp. 1457-1462
-
-
Itoh, T.1
Linn, S.2
-
9
-
-
38949093780
-
MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2
-
Jin Y, Zeng SX, Sun XX, Lee H, Blattner C, Xiao Z, Lu H. 2008. MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2. Mol Cell Biol 28:1218-1229.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 1218-1229
-
-
Jin, Y.1
Zeng, S.X.2
Sun, X.X.3
Lee, H.4
Blattner, C.5
Xiao, Z.6
Lu, H.7
-
10
-
-
30944468153
-
Expression of the Bcl-3 proto-oncogene suppresses TP53 activation
-
Kashatus D, Cogswell P, Baldwin AS. 2006. Expression of the Bcl-3 proto-oncogene suppresses TP53 activation. Genes Dev 20:225-235.
-
(2006)
Genes Dev
, vol.20
, pp. 225-235
-
-
Kashatus, D.1
Cogswell, P.2
Baldwin, A.S.3
-
11
-
-
34247371033
-
Cell survival, cell death and cell cycle pathways are interconnected: Implications for cancer therapy
-
Maddika S, Ande SR, Panigrahi S, Paranjothy T, Weglarczyk K, Zuse A, Eshraghi M, Manda KD, Wiechec E, Los M. 2007. Cell survival, cell death and cell cycle pathways are interconnected: Implications for cancer therapy. Drug Resist Updat 10:13-29.
-
(2007)
Drug Resist Updat
, vol.10
, pp. 13-29
-
-
Maddika, S.1
Ande, S.R.2
Panigrahi, S.3
Paranjothy, T.4
Weglarczyk, K.5
Zuse, A.6
Eshraghi, M.7
Manda, K.D.8
Wiechec, E.9
Los, M.10
-
12
-
-
10744230086
-
-
Mancini F, Gentiletti F, D'Angelo M, Giglio S, Nanni S, D'Angelo C, Farsetti A, Citro G, Sacchi A, Pontecorvi A, Moretti F. MDM4 (MDMX) overexpression enhances stabilization of stress-induced TP53 and promotes apoptosis. 2004. J Biol Chem 279:8169-8180.
-
Mancini F, Gentiletti F, D'Angelo M, Giglio S, Nanni S, D'Angelo C, Farsetti A, Citro G, Sacchi A, Pontecorvi A, Moretti F. MDM4 (MDMX) overexpression enhances stabilization of stress-induced TP53 and promotes apoptosis. 2004. J Biol Chem 279:8169-8180.
-
-
-
-
14
-
-
0036467391
-
The TP53 and MDM2 families in cancer
-
Michael D, Oren M. 2002. The TP53 and MDM2 families in cancer. Curr Opin Genet Dev 12:53-59.
-
(2002)
Curr Opin Genet Dev
, vol.12
, pp. 53-59
-
-
Michael, D.1
Oren, M.2
-
15
-
-
0028883179
-
Tumor suppressor TP53 is a direct transcriptional activator of the human bax gene
-
Miyashita T, Reed JC. 1995. Tumor suppressor TP53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299.
-
(1995)
Cell
, vol.80
, pp. 293-299
-
-
Miyashita, T.1
Reed, J.C.2
-
16
-
-
0033959744
-
MDM2-master regulator of the TP53 tumor suppressor protein
-
Momand J, Wu HH, Dasgupta G. 2000. MDM2-master regulator of the TP53 tumor suppressor protein. Gene 242:15-29.
-
(2000)
Gene
, vol.242
, pp. 15-29
-
-
Momand, J.1
Wu, H.H.2
Dasgupta, G.3
-
18
-
-
0034863683
-
Rescue of embryonic lethality in Mdm4-null mice by loss of TrTP53 suggests a nonoverlapping pathway with MDM2 to regulate TP53
-
Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G. 2001. Rescue of embryonic lethality in Mdm4-null mice by loss of TrTP53 suggests a nonoverlapping pathway with MDM2 to regulate TP53. Nat Genet 29:92-95.
-
(2001)
Nat Genet
, vol.29
, pp. 92-95
-
-
Parant, J.1
Chavez-Reyes, A.2
Little, N.A.3
Yan, W.4
Reinke, V.5
Jochemsen, A.G.6
Lozano, G.7
-
19
-
-
20144387944
-
Phosphorylation of Hdmx mediates its Hdm2-and ATM-dependent degradation in response to DNA damage
-
Pereg Y, Shkedy D, de Graaf P, Meulmeester E, Edelson-Averbukh M, Salek M, Biton S, Teunisse AF, Lehmann WD, Jochemsen AG, Shiloh Y. 2005. Phosphorylation of Hdmx mediates its Hdm2-and ATM-dependent degradation in response to DNA damage. Proc Natl Acad Sci USA 102:5056-5061.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 5056-5061
-
-
Pereg, Y.1
Shkedy, D.2
de Graaf, P.3
Meulmeester, E.4
Edelson-Averbukh, M.5
Salek, M.6
Biton, S.7
Teunisse, A.F.8
Lehmann, W.D.9
Jochemsen, A.G.10
Shiloh, Y.11
-
20
-
-
43049150355
-
Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties
-
Prodosmo A, Giglio S, Moretti S, Mancini F, Barbi F, Avenia N, Di Conza G, Schünemann HJ, Pistola L, Ludovini V, Sacchi A, Pontecorvi A, Puxeddu E, Moretti F. 2008. Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties. J Mol Med 86:585-596.
-
(2008)
J Mol Med
, vol.86
, pp. 585-596
-
-
Prodosmo, A.1
Giglio, S.2
Moretti, S.3
Mancini, F.4
Barbi, F.5
Avenia, N.6
Di Conza, G.7
Schünemann, H.J.8
Pistola, L.9
Ludovini, V.10
Sacchi, A.11
Pontecorvi, A.12
Puxeddu, E.13
Moretti, F.14
-
21
-
-
34249306228
-
Expression of CDKN1A(Waf1/Cip1), p57(Kip2) and HER2/new in patients with gallbladder cancer
-
Puhalla H, Wrba F, Kandioler D, Lehnert M, Huynh A, Gruenberger T, Tamandl D, Filipits M. 2007. Expression of CDKN1A(Waf1/Cip1), p57(Kip2) and HER2/new in patients with gallbladder cancer. Anticancer Res 27:1679-1684.
-
(2007)
Anticancer Res
, vol.27
, pp. 1679-1684
-
-
Puhalla, H.1
Wrba, F.2
Kandioler, D.3
Lehnert, M.4
Huynh, A.5
Gruenberger, T.6
Tamandl, D.7
Filipits, M.8
-
22
-
-
0037007427
-
Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes
-
Qin JZ, Chaturvedi V, Denning MF, Bacon P, Panella J, Choubey D, Nickoloff BJ. 2002. Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes. Oncogene 21:2991-3002.
-
(2002)
Oncogene
, vol.21
, pp. 2991-3002
-
-
Qin, J.Z.1
Chaturvedi, V.2
Denning, M.F.3
Bacon, P.4
Panella, J.5
Choubey, D.6
Nickoloff, B.J.7
-
23
-
-
0037431518
-
Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target
-
Riemenschneider MJ, Knobbe CB, Reifenberger G. 2003. Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target. Int J Cancer 104:752-757.
-
(2003)
Int J Cancer
, vol.104
, pp. 752-757
-
-
Riemenschneider, M.J.1
Knobbe, C.B.2
Reifenberger, G.3
-
24
-
-
0034623074
-
Hdmx stabilizes MDM2 and TP53
-
Stad R, Ramos YFM, Little N, Grivell S, Attema J, van Der Eb AJ, Jochemsen AG. 2000. Hdmx stabilizes MDM2 and TP53. J Biol Chem 275:28039-28044.
-
(2000)
J Biol Chem
, vol.275
, pp. 28039-28044
-
-
Stad, R.1
Ramos, Y.F.M.2
Little, N.3
Grivell, S.4
Attema, J.5
van Der, E.A.6
Jochemsen, A.G.7
-
25
-
-
0942290415
-
Absence of CDKN1A(Cip1/waf1) partially rescues MDM4 loss and uncovers an antiproliferative effect of MDM4 on cell growth
-
Steinman HA, Sluss HK, Sands AT, Pihan G, Jones SN. 2004. Absence of CDKN1A(Cip1/waf1) partially rescues MDM4 loss and uncovers an antiproliferative effect of MDM4 on cell growth. Oncogene 23:303-306.
-
(2004)
Oncogene
, vol.23
, pp. 303-306
-
-
Steinman, H.A.1
Sluss, H.K.2
Sands, A.T.3
Pihan, G.4
Jones, S.N.5
-
26
-
-
52049101592
-
High-resolution array-based comparative genomic hybridization of bladder cancers identifies mouse double minute 4 (MDM4) as an amplification target exclusive of MDM2 and TP53
-
Veerakumarasivam A, Scott HE, Chin SF, Warren A, Wallard MJ, Grimmer D, Ichimura K, Caldas C, Collins VP, Neal DE, Kelly JD. 2008. High-resolution array-based comparative genomic hybridization of bladder cancers identifies mouse double minute 4 (MDM4) as an amplification target exclusive of MDM2 and TP53. Clin Cancer Res 14:2527-2534.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2527-2534
-
-
Veerakumarasivam, A.1
Scott, H.E.2
Chin, S.F.3
Warren, A.4
Wallard, M.J.5
Grimmer, D.6
Ichimura, K.7
Caldas, C.8
Collins, V.P.9
Neal, D.E.10
Kelly, J.D.11
|