1,4-syn-Asymmetric induction in the titanium-mediated aldol reactions of chiral methyl α-silyloxy ketones

Tetrahedron Letters

Volumn 51, Issue 6, 2010, Pages 942-945

  Lorente, Adriana ^a   Pellicena, Miquel ^a   Romea, Pedro ^a   Urpí, Fèlix ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Acetate aldol reactions; Chiral ketones; Stereoselective reactions; Titanium enolates

Indexed keywords

ALDEHYDE DERIVATIVE; KETONE DERIVATIVE; SILANE; TITANIUM;

ALDOL REACTION; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DRUG SYNTHESIS; SILYLATION;

EID: 73249118765     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.12.046     Document Type: Article

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34. The aldol reaction was also carried out at -94 °C. However, it turned out to be too sluggish and required longer reaction times.
35. 4) and concentrated. The resulting oil was analyzed by NMR and purified by flash chromatography (hexanes/EtOAc).
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