The role of Sgk-1 in the upregulation of transport proteins by PPAR-γ agonists in human proximal tubule cells

Nephrology Dialysis Transplantation

Volumn 24, Issue 4, 2009, Pages 1130-1141

  Saad, Sonia ^a   Agapiou, David J ^a   Chen, Xin Ming ^a   Stevens, Veronica ^a   Pollock, Carol A ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Diabetes mellitus; Sodium transport; Water channel

Indexed keywords

AQUAPORIN 1; AQUAPORIN 7; GSK 650394A; GSK650394A; L 805645; L805645; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PROTEIN SERINE THREONINE KINASE INHIBITOR; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SMALL INTERFERING RNA; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; SODIUM ABSORPTION; SODIUM TRANSPORT; UPREGULATION; WESTERN BLOTTING;

CARRIER PROTEINS; CELLS, CULTURED; HUMANS; IMMEDIATE-EARLY PROTEINS; KIDNEY TUBULES, PROXIMAL; PPAR GAMMA; PROTEIN-SERINE-THREONINE KINASES; UP-REGULATION;

EID: 65349084594     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn614     Document Type: Article

References (40)

1. Kobayashi T, Deak M, Morrice N et al. Characterization of the structure and regulation of two novel isoforms of serum and glucocorticoidinduced protein kinase. Biochem J 1999; 344: 189-197
2. Friedrich B, Feng Y, Cohen P, et al. The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha, beta, gamma-ENaC. Pflugers Arch 2003; 445: 693-696
3. Pearce D, Verrey F, Chen SY et al. Role of SGK in mineralocorticoidregulated sodium transport. Kidney Int 2000; 57: 1283-1289
4. Debonneville C, Flores SY, Kamynina E et al. Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J 2001; 20: 7052-7059
5. GormleyK,Dong Y, Sagnella GA. Regulation of the epithelial sodium channel by accessory proteins. Biochem J 2003; 371: 1-14
6. Alvarez de la Rosa D, Canessa CM. Role of SGK in hormonal regulation of epithelial sodium channel in A6 cells. Am J Physiol 2003; 284: C404-C414
7. Saad S, Stevens V, Poronnik P et al. High glucose transactivates the EGF receptor and up-regulates serum glucocorticoid kinase in the proximal tubule. Kidney Int 2005; 68: 985-997
8. StevensVA, Saad S, Poronnik P et al. The role of SGK-1 in angiotensin II-mediated sodium reabsorption in human proximal tubular cells. Nephrol Dial Transplant 2008; 23: 1834-1843
9. Lang F, Klingel K, Wagner CA et al. Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy. Proc Natl Acad Sci U S A 2000; 97: 8157-8862
10. Miyata KS, McCaw SE, Marcus SL et al. The peroxisome proliferators-activated receptor interacts with the retinoid X receptor in vivo. Gene 1994; 148: 327-330
11. Panchapakesan U, Pollock CA, Chen X-M. The effect of high glucose and peroxisome proliferators-activated receptor gamma (PPARγ) agonists on PPARγ expression and function in HK-2 cells. Am J Physiol Renal Physiol 2004; 287: 528-534
12. Panchapakesan U, Chen X, Pollock CA. Drug insight: thiazolidinediones and diabetic nephropathy-relevance to renoprotection. Nat Clin Pract Nephrol 2005; 1: 33-42
13. Panchapakesan U, Sumual S, Pollock CA et al. PPAR gamma agonists exert antifibrotic effects in renal tubular cells exposed to high glucose. Am J Physiol Renal Physiol 2005; 289: F1153-F1158
14. Zafiriou S, Stanners SR, Polhill TS et al. Pioglitazone increases renal tubular albumin uptake but limits pro-inflammatory and fibrotic responses. Kidney Int 2004; 65: 1647-1653
15. Zafiriou S, Stanners SR, Saad S et al. Pioglitazone inhibits cell growth and reduces matrix production in the human kidney fibroblasts. J Am Soc Nephrol 2005; 16: 638-645
16. Hong G, Lockhart A, Davis B et al. PPAR gamma activation enhances cell surface ENaC alpha via up-regulation of SGK1 in human collecting duct cells. FASEB J 2003; 17: 1966-1968
17. Chen L, Yang B, McNulty JA et al. GI262570, a peroxisome proliferators-activated receptor gamma agonist, changes electrolytes and water reabsorption from the distal nephron in rats. J Pharmacol Exp Ther 2005; 312: 718-725
18. Guan Y, Hao C, Cha DR et al. Thiazolidinediones expand body fluid volume through PPAR gamma stimulation of ENaC-mediated renal salt absorption. Nat Med 2005; 11: 861-866
19. Zhang H, Zhang A, Kohan DE et al. Collecting duct-specific deletion of peroxisome proliferators-activated receptor gamma blocks thiazolidinedione-induced fluid retention. Proc Natl Acad Sci U S A2005; 102: 9406-9411
20. Sohara E, Rai T, Miyazaki J et al. Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol 2005; 289: F1193-F1200
21. Song J, KnepperMA, HuXet al. Rosiglitazone activates renal sodium and water reabsorptive pathways and lowers blood pressure in normal rats. J Pharmacol Exp Ther 2004; 308: 426-433
22. Rozansky DJ, Wang J, Doan N et al. Hypotonic induction of SGK1 and Na+ transport in A6 cells. Am J Physiol Renal Physiol 2002; 283: F105-F113
23. Johnson D W, Saunders HJ, Brew BK et al. Human renal fibroblasts modulate proximal tubule cell growth and transport via the IGF-I axis. Kidney Int 1997; 52: 1486-1496
24. Qi W, JohnsonDW,VessyDAet al. Isolation, propagation and characterization of primary tubule cell culture from human kidney. Nephrology (Carlton) 2007; 12: 155-159
25. Berger J, Wagner JA. Physiological and therapeutic roles of peroxisome proliferator-activated receptors. Diabetes Technol Ther 2002; 4: 163-174
26. Sherk AB, Frigo DE, Schnackenberg CG et al. Development of a small-molecule serum- and glucocorticoid-regulated kinase- 1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res2008; 68: 7475-7483
27. Moon C, Rousseau R, Soria JC et al. Aquaporin expression in human lymphocytes and dendritic cells. Am J Hematol 2004; 75: 128-133
28. Wang W, Hart PS, Piesco NP et al. Aquaporin expression in developing human teeth and selected orofacial tissues. Calcif Tissue Int 2003; 72: 222-227
29. Pollock CA, Lawrence JR, Field MJ. Tubular sodium handling and tubuloglomerular feedback in experimental diabetes mellitus. Am J Physiol 1991; 260: F946-F952
30. Pollock CA, Field MJ, Bostrom TE et al. Proximal tubular cell sodium concentration in early diabetic nephropathy assessed by electron microprobe analysis. Pfl̈ugers Arch 1991; 418: 14-17
31. Pollock CA, Field MJ. Renal handling of endogenous lithium in experimental diabetes mellitus. Clin Exp Pharmacol Physiol 1992; 19: 201-207
32. Bickel CA, Knepper MA, Verbalis JG et al. Dysregulation of renal salt and water transport proteins in diabetic Zucher rats. Kidney Int2002; 61: 2099-2110
33. Klisic J, Nief V, Reyes L et al. Acute and chronic regulation of the renal Na/H+ exchanger NHE3 in rats with STZ-induced diabetes mellitus. Nephron Physiol 2006; 102: 7-35
34. Dormandy JA, Charbonnel B, Eckland DJ et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005; 366: 1279-1289
35. Thomas ML, Lloyd SJ. Pulmonary edema associated with rosiglitazone and troglitazone. Ann Pharmacother 2001; 35: 123-124
36. Guan Y. Targeting peroxisome proliferator-activated receptors (PPARs) in kidney and urologic disease. Minerva Urol Nefrol 2002; 54: 65-79
37. Zanchi A, Chiolero A, Maillard M et al. Effects of the peroxisomal proliferator-activated receptor-gamma agonist pioglitazone on renal and hormonal responses to salt in healthy men. J Clin Endocrinol Metab 2004; 89: 1140-1145
38. Nofziger C, Chen L, Shane MA et al. PPAR gamma agonists do not directly enhance basal or insulin-stimulated Na(+) transport via the epithelial Na(+) channel. Pflugers Arch. 2005; 451: 445-453
39. Schnermann J, Chou CL,Ma T et al. Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice. Proc Natl Acad Sci U S A 1998; 95: 9660-9664
40. Schnermann J. Sodium transport deficiency and sodium balance in gene-targeted mice. Acta Physiol Scand 2001; 173: 59-66