Effects of aprotinin on endothelium-dependent relaxation of large coronary arteries

European Journal of Cardio-thoracic Surgery

Volumn 28, Issue 6, 2005, Pages 801-804

  Fischer, Jürgen H ^a   Steinhoff, Maren ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Aprotinin; Coronary artery; EDHF; Endothelium dependent relaxation (EDR)

Indexed keywords

APROTININ; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; INDOMETACIN; N(G) NITROARGININE; NITRIC OXIDE; PROSTAGLANDIN F2 ALPHA; SUBSTANCE P; UREA;

ANIMAL TISSUE; AORTA; ARTERY CONSTRICTION; ARTERY ENDOTHELIUM; BODY TEMPERATURE; CALCULATION; COLD; CONFERENCE PAPER; CONTROLLED STUDY; CORONARY ARTERY DILATATION; DRUG EFFECT; DRUG EXPOSURE; DRUG MEGADOSE; LABORATORY; MAMMAL; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; RODENT; SLAUGHTERHOUSE; SWINE;

ANIMALS; APROTININ; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HEMOSTATICS; NITRIC OXIDE; SWINE; VASODILATION;

EID: 28444438092     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2005.09.015     Document Type: Conference Paper

References (25)

1. D.P. Taggart, V. Djapardy, M. Naik, and A. Davies A randomized trial of aprotinin (Trasylol) on blood loss, blood product requirement, and myocardial injury in total arterial grafting J Thorac Cardiovasc Surg 126 2003 1087 1094
2. C.M. Samama, O. Langeron, N. Rosencher, X. Cap, P. Rouche, M. Pegoix, J. Berniere, and P. Coriat Aprotinin versus placebo in major orthopedic surgery: a randomized, double-blinded, dose-ranging study Anesth Analg 95 2002 287 293
3. G.M. Patrassi, M. Viero, M.T. Sartori, G. De Silvestro, L. Rossaro, P. Burra, M.L. Nolli, P. Piccinni, and N. Bassi Aprotinin efficacy on intraoperative bleeding and transfusion requirements in orthotopic liver transplantation Transfusion 34 1994 507 511
4. B. Waxler, and S.F. Rabito Aprotin: a serine protease inhibitor with therapeutic actions: its interaction with ACE inhibitors Curr Pharm Des 9 2003 777 787
5. H. Mossinger, W. Dietrich, S.L. Braun, M. Jochum, H. Meisner, and J.A. Richter High-dose aprotinin reduces activation of hemostasis, allogeneic blood requirement, and duration of postoperative ventilation in pediatric cardiac surgery Ann Thorac Surg 75 2003 430 437
6. D. Schmartz, Y. Tabardel, J.C. Preiser, L. Barvais, A. dHollander, J. Duchateau, and J.L. Vincent Does aprotinin influence the inflammatory response to cardiopulmonary bypass in patients? J Thorac Cardiovasc Surg 125 2003 184 190
7. G. Asimakopoulos, E.A. Lidington, J. Mason, D.O. Haskard, K.M. Taylor, and R.C. Landis Effect of aprotinin on endothelial cell activation J Thorac Cardiovasc Surg 122 1 2001 123 128
8. C.F. Mojcik, and J.H. Levy Aprotinin and the systemic inflammatory response after cardiopulmonary bypass Ann Thorac Surg 71 2001 745 754
9. M.G. Fitzsimons, R.A. Peterfreund, and D.E. Raines Aprotinin administration and pulmonary thromboembolism during orthotopic liver transplantation: report of two cases Anesth Analg 92 2001 1418 1421
10. P.R. Feindt, S. Walcher, I. Volkmer, H.E. Keller, U. Straub, H. Huwer, U.T. Seyfert, T. Petzold, and E. Gams Effects of high dose aprotinin on renal function in aortocoronary bypass grafting Ann Thorac Surg 60 1995 1076 1080
11. J.H. Fischer Trasylol-Effekte an der Niere - Temperatur- und Dosisabhängigkeit R. Dudziak H.D. Reuter G. Kirchhoff F. Schumann Proteolyse und Proteinaseninhibition in der Herz- und Gefäßchirurgie 1985 Schattauer Stuttgart, New York 127 134
12. T.M. Sundt III, N.T. Douchoukos, J.E. Saffitz, S.F. Murphy, T.H. Wareing, and D.J. Stahl Renal dysfunction and intravascular coagulation with aprotinin and hypothermic circulatory arrest Ann Thorac Surg 55 1993 1418 1424
13. J.H. Fischer, and H.R. Casser Aprotinin (Trasylol) protection - unsuitable for hypothermic kidney preservation Transplantation 37 1984 115
14. D.M. Cosgrove, B. Heric, B.W. Lytle, P.C. Taylor, R. Novoa, L.A.R. Golding, R.W. Stewart, P.M. Mccarthy, and F.D. Loop Aprotinin therapy for reoperative myocardial revascularization - a placebo-controlled study Ann Thorac Surg 54 1992 1031 1038
15. S. Ülker, M.G. Cinar, U. Bayraktutan, and A. Evinc Aprotinin impairs endothelium-dependent relaxation in rat aorta and inhibits nitric oxide release from rat coronary endothelial cells Cardiovasc Res 50 2001 589 596
16. J.H. Fischer, C. Funcke, G. Yotsumoto, S. Jeschkeit-Schubbert, and F. Kuhn-Régnier Maintenance of physiological coronary endothelial function after 3.3 h of hypothermic oxygen persufflation preservation and orthotopic transplantation of non-heart-beating donor hearts Eur J Cardiothorac Surg 25 2004 98 104
17. S. Allen, N. Anastasiou, D. Royston, R. Paniagua, and M. Yacoub Effect of aprotinin on vascular reactivity of coronary bypass grafts J Thorac Cardiovasc Surg 113 1997 319 326
18. J.H. Hardy, and J. Desroches Natural and synthetic antifibrinolytics in cardiac surgery Can J Anaesth 23 1992 251 255
19. F.F.Y. Lam Pharmacologic characterization of receptor types mediating coronary vasodilator actions of sensory neuropeptides in the guinea pig J Cardiovasc Pharmacol 35 2000 646 652
20. D.E. Newby, R.A. Wright, P. Dawson, C.A. Ludlam, N.A. Boon, K.A.A. Fox, and D.J. Webb The l-arginine/nitric oxide pathway contributes to the acute release of tissue plasminogen activator in vivo in man Cardiovasc Res 38 1998 485 492
21. M.P. Burnham, R. Bychkov, M. Feletou, G.R. Richards, P.M. Vanhoutte, A.H. Weston, and G. Edwards Characterization of an apamin-sensitive small-conductance Ca2+-activated K+ channel in porcine coronary artery endothelium: relevance to EDHF Br J Pharmacol 135 2002 1133 1143
22. D. Regoli, P. D'Orleans-Juste, E. Escher, and J. Mizrahi Receptors for substance P.I. The pharmacological preparations Eur J Pharmacol 97 1984 161 170
23. R.F. Furchgott Endothelium-derived relaxing factor: discovery, early studies, and identification as nitric oxide Angew Chem Int Ed 38 1999 1871 1880
24. B.C. Yang, W.W. Nichols, and J.L. Mehta Cardiac effects of acetylcholine in rat hearts - role of endothelium-derived relaxing factor and prostaglandins Am J Physiol 264 1993 H1388 H1393
25. S.P. Marrelli Altered endothelial Ca2+ regulation after ischemia/reperfusion produces potentiated endothelium-derived hyperpolarizing factor-mediated dilations Stroke 33 2002 2285 2291