The pH shift and precursor feeding strategy in a low-toxicity FR-008/candicidin derivative CS103 fermentation bioprocess by a mutant of streptomyces sp. FR-008

Applied Biochemistry and Biotechnology

Volumn 159, Issue 3, 2009, Pages 673-686

  Mao, Xiangzhao ^a,b   Wang, Feng ^a   Zhang, Jianguo ^a   Chen, Shi ^c   Deng, Zixin ^c   Shen, Yaling ^a   Wei, Dongzhi ^b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Fermentation; Low toxicity FR 008 candicidin; Polyene macrolides antibiotic; Precursor feeding; Two stage pH control strategy

Indexed keywords

MACROLIDES; PH CONTROL; POLYENE MACROLIDES ANTIBIOTIC; PRECURSOR FEEDING; TWO STAGE;

ANTIBIOTICS; BATCH CELL CULTURE; BIOCHEMISTRY; FEEDING; ORGANIC COMPOUNDS; PH EFFECTS; PREDICTIVE CONTROL SYSTEMS; TOXICITY;

FERMENTATION;

CANDICIDIN; CS 103; CYTOCHROME P450; POLYENE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

BACTERIAL STRAIN; BACTERIUM CULTURE; BIOMASS FERMENTATION; BIOPROCESS; BIOREACTOR; CHEMICAL STRUCTURE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG SYNTHESIS; GENE DELETION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MYCELIUM; NONHUMAN; PH; PRECURSOR; STREPTOMYCES; TOXICITY;

CANDICIDIN; FERMENTATION; HYDROGEN-ION CONCENTRATION; MUTATION; STREPTOMYCES;

STREPTOMYCES SP. FR-008;

EID: 73149098720     PISSN: 02732289     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12010-008-8502-y     Document Type: Conference Paper

References (17)

1. Bolard, J. (1986). How do the polyene macrolide antibiotics affect the cellular membrane properties? Biochimica et Biophysica Acta, 864, 257-304.
2. Gil, J. A., Naharro, G., Villanueva, J. R., & Martin, J. F. (1985). Characterization and regulation of paminobenzoic acid synthase from Streptomyces griseus. Journal of General Microbiology, 131, 1279-1287.
3. Yuan, D., & Zhou, Q. (1990). The killing activity to mosquito larvae of a new antibiotic produced by FR-008, an intra-specific fusant of S. hygroscopicus var. yingchengensis. Journal of Huazhong Agricultural University, 9, 209.
4. Gordon, H. W. S. C. P. (1968). The effect of polyene macrolides on the prostate gland and canine prostatic hyperplasia. Proceedings of the National Academy of Sciences of the United States of America, 60, 1201-1208. doi:10.1073/pnas.60.4.1201.
5. Singhal, A. K., Mosbach, E. H., & Schaffner, C. P. (1981). Effect of candicidin on cholesterol and bile acid metabolism in the rat. Lipids, 16, 423-426. doi:10.1007/BF02535009. (Pubitemid 11036489)
6. Waksman, S. A., Lechevalier, H. A., & Schaffner, C. P. (1965). Candicidin and other polyenic antifungal antibiotics. Bulletin of the World Health Organization, 33, 219-226.
7. Liu, C. M., McDaniel, L. E., & Schaffner, C. P. (1972). Studies on candicidin biogenesis. The Journal of Antibiotics, 25, 116-121.
8. Chen, S., Huang, X., Zhou, X., Bai, L., He, J., Jeong, K. J., et al. (2003). Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex. Chemistry & Biology, 10, 1065-1076. doi:10.1016/j.chembiol.2003.10.007. (Pubitemid 37496437)
9. Cheron, M., Cybulska, B., Mazerski, J., Grzybowska, J., Czerwinski, A., & Borowski, E. (1988). Quantitative structure-activity relationships in amphotericin B derivatives. Biochemical Pharmacology, 37, 827-836. doi:10.1016/0006-2952(88)90168-2. (Pubitemid 18058452)
10. Carmody, M., Murphy, B., Byrne, B., Power, P., Rai, D., Rawlings, B., et al. (2005). Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups. The Journal of Biological Chemistry, 280, 34420-34426. doi:10.1074/jbc.M506689200. (Pubitemid 41504569)
11. Herve, M., Debouzy, J. C., Borowski, E., Cybulska, B., & Gary-Bobo, C. M. (1989). The role of the carboxyl and amino groups of polyene macrolides in their interactions with sterols and their selective toxicity: A 31P-NMR study. Biochimica et Biophysica Acta, 980, 261-272. doi:10.1016/0005-2736(89)90312-X. (Pubitemid 19224656)
12. Mao, X. Z., Shen, Y. L., Yang, L., Chen, S., Yang, Y. P., Yang, J. Y., et al. (2007). Optimizing the medium compositions for accumulation of the novel FR-008/candicidin derivatives CS101 by a mutant of Streptomyces sp. Using statistical experimental methods. Process Biochemistry, 42, 878-883. doi:10.1016/j.procbio.2007.01.004. (Pubitemid 46528333)
13. Choi, S. U., Paik, H. D., Lee, S. C., Nihira, T., & Hwang, Y. I. (2004). Enhanced productivity of human lysozyme by pH-controlled batch fermentation of recombinant Saccharomyces cerevisiae. Journal of Bioscience and Bioengineering, 98, 132-135.
14. Luedeking, R., & Piret, E. L. (2000). A kinetic study of the lactic acid fermentation. Batch process at controlled pH. Biotechnology and Bioengineering, 67, 636-644 (Reprinted from Journal of Biochemical and Microbiological Technology Engineering, I(4), 393-412 (1959). doi:10.1002/(SICI)1097-0290(20000320)67:6<636::AID-BIT3>3.0.CO;2-U. (Pubitemid 30567676)
15. Wunschel, D. S., Hill, E. A., McLean, J. S., Jarman, K., Gorby, Y. A., Valentine, N., et al. (2005). Effects of varied pH, growth rate and temperature using controlled fermentation and batch culture on matrix assisted laser desorption/ionization whole cell protein fingerprints. Journal of Microbiological Methods, 62, 259-271. doi:10.1016/j.mimet.2005.04.033. (Pubitemid 41140116)
16. Mao, X. Z., Shen, Y. L., Wei, D. Z., Chen, S., & Deng, Z. X. (2005). Determination of candicidin/FR-008 and their ramification in fermentation broth by RP-HPLC. Journal of Chinese Pharmaceutical Sciences, 42, 115-118.
17. Roszkowski, J., Ruczaj, Z., Sawnor-Korszynska, D., Kotiuszko, D., Morawska, H., Siejko, D., et al. (1971). NADPH-regenerating systems in microorganisms producing macrolide antibiotics. Acta Microbiologica Polonica. Series B: Microbiologia Applicata, 3, 97-106.