Deficiency in activation-induced cytidine deaminase promotes systemic autoimmunity in lpr mice on a C57BL/6 background

Clinical and Experimental Immunology

Volumn 159, Issue 2, 2010, Pages 169-175

  Chen, L ^a   Guo, L ^a   Tian, J ^a   Zheng, B ^a   Han, S ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

AID; Autoantibodies; Autoimmunity; Lupus

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; FAS ANTIBODY; IMMUNOGLOBULIN M ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY AFFINITY; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DISEASE MODEL; GENE MUTATION; GERMINAL CENTER; GLOMERULONEPHRITIS; IMMUNOPATHOGENESIS; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SPLENOMEGALY; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; ANTIGENS, CD3; AUTOANTIBODIES; AUTOIMMUNE DISEASES; CROSSES, GENETIC; CYTIDINE DEAMINASE; FEMALE; FLOW CYTOMETRY; GERMINAL CENTER; GLOMERULONEPHRITIS; IMMUNOGLOBULIN M; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED MRL LPR; MICE, KNOCKOUT; SPLENOMEGALY; T-LYMPHOCYTES; URINALYSIS;

EID: 72949122120     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2009.04058.x     Document Type: Article

References (26)

1. Theofilopoulos AN, Dixon FJ. Murine models of systemic lupus erythematosus. Adv Immunol 1985 37 : 269 390.
2. Kotzin BL. Systemic lupus erythematosus. Cell 1996 85 : 303 306.
3. Feldmann M, Brennan FM, Maini RN. Rheumatoid arthritis. Cell 1996 85 : 307 310.
4. Tsao BP, Ohnishi K, Cheroutre H et al. Failed self-tolerance and autoimmunity in IgG anti-DNA transgenic mice. J Immunol 1992 149 : 350 358.
5. Ohnishi K, Ebling FM, Mitchell B, Singh RR, Hahn BH, Tsao BP. Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics. Int Immunol 1994 6 : 817 830.
6. Ehrenstein MR, Katz DR, Griffiths MH et al. Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice. Kidney Int 1995 48 : 705 711.
7. Radic MZ, Ibrahim SM, Rauch J, Camper SA, Weigert M. Constitutive secretion of transgene-encoded IgG2b autoantibodies leads to symptoms of autoimmune disease. J Immunol 1995 155 : 3213 3222.
8. Vaughan JH. 1992 Joseph J. Bunim Lecture. Pathogenetic concepts and origins of rheumatoid factor in rheumatoid arthritis. Arthritis Rheum 1993 36 : 1 6.
9. Korganow AS, Ji H, Mangialaio S et al. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 1999 10 : 451 461.
10. Ravetch JV, Bolland S. IgG Fc receptors. Annu Rev Immunol 2001 19 : 275 290.
11. Katz MS, Foster MH, Madaio MP. Independently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequences. J Clin Invest 1993 91 : 402 408.
12. Ito MR, Terasaki S, Kondo E, Shiwaku H, Fukuoka Y, Nose M. Experimental lupus nephritis in severe combined immunodeficient (SCID) mice: remodelling of the glomerular lesions by bystander IgM antibodies. Clin Exp Immunol 2000 119 : 340 345.
13. Youd ME, Luus L, Corley RB. IgM monomers accelerate disease manifestations in autoimmune-prone Fas-deficient mice. J Autoimmun 2004 23 : 333 343.
14. Forger F, Matthias T, Oppermann M, Becker H, Helmke K. Clinical significance of anti-dsDNA antibody isotypes: IgG/IgM ratio of anti-dsDNA antibodies as a prognostic marker for lupus nephritis. Lupus 2004 13 : 36 44.
15. Boes M, Schmidt T, Linkemann K, Beaudette BC, Marshak-Rothstein A, Chen J. Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM. Proc Natl Acad Sci USA 2000 97 : 1184 1189.
16. Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000 102 : 553 563.
17. Revy P, Muto T, Levy Y et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell 2000 102 : 565 575.
18. Honjo T, Kinoshita K, Muramatsu M. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu Rev Immunol 2002 20 : 165 196.
19. Zheng B, Zhang X, Guo L, Han S. IgM plays an important role in induction of collagen-induced arthritis. Clin Exp Immunol 2007 149 : 579 585.
20. Han S, Cao S, Bheekha-Escura R, Zheng B. Germinal center reaction in the joints of mice with collagen-induced arthritis: an animal model of lymphocyte activation and differentiation in arthritis joints. PG-1438-43. Arthritis Rheum 2001 44 : 1438 1443.
21. Kelley VE, Roths JB. Interaction of mutant lpr gene with background strain influences renal disease. Clin Immunol Immunopathol 1985 37 : 220 229.
22. Bleesing JJ, Brown MR, Novicio C et al. A composite picture of TcR alpha/beta(+) CD4(-)CD8(-) T cells (alpha/beta-DNTCs) in humans with autoimmune lymphoproliferative syndrome. Clin Immunol 2002 104 : 21 30.
23. Shi X, Xie C, Kreska D, Richardson JA, Mohan C. Genetic dissection of SLE: SLE1 and FAS impact alternate pathways leading to lymphoproliferative autoimmunity. J Exp Med 2002 196 : 281 292.
24. Shlomchik MJ, Madaio MP, Ni D, Trounstein M, Huszar D. The role of B cells in lpr/lpr-induced autoimmunity. J Exp Med 1994 180 : 1295 1306.
25. Hase K, Takahashi D, Ebisawa M, Kawano S, Itoh K, Ohno H. Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease. PLoS ONE 2008 3 : e3033.
26. Quartier P, Bustamante J, Sanal O et al. Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to activation-induced cytidine deaminase deficiency. Clin Immunol 2004 110 : 22 9.