From manganism to manganese-induced parkinsonism: A conceptual model based on the evolution of exposure

NeuroMolecular Medicine

Volumn 11, Issue 4, 2009, Pages 311-321

  Lucchini, Roberto G ^a   Martin, Christopher J ^b   Doney, Brent C ^c  

^a UNIVERSITY OF BRESCIA   (Italy)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Manganese poisoning; Manganism; Neurotoxicity; Occupational exposure; Parkinsonian disorders

Indexed keywords

LEVODOPA; MANGANESE;

BIOLOGY; CLINICAL FEATURE; DISEASE COURSE; ENVIRONMENT; EVOLUTION; HUMAN; INGESTION; INHALATION; MANGANISM; MEDICAL LITERATURE; MODEL; NEUROTOXICITY; NONHUMAN; OCCUPATIONAL DISEASE; PARKINSONISM; POPULATION; PRIORITY JOURNAL; REVIEW;

ALPHA-SYNUCLEIN; BASAL GANGLIA; ENVIRONMENTAL EXPOSURE; GLOBUS PALLIDUS; HUMANS; MALE; MANGANESE; MANGANESE POISONING; OCCUPATIONAL EXPOSURE; PARKINSON DISEASE, SECONDARY; PROTON-TRANSLOCATING ATPASES; SUBSTANTIA NIGRA; UBIQUITIN-PROTEIN LIGASES; WELDING;

PARKINSONIA;

EID: 72949108889     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12017-009-8108-8     Document Type: Review

References (96)

1. ®. Cincinnati, OH.
2. GS Agarwal R Sharma V Bhatnagar 2008 Assessment of latent manganese toxicity as a prognostic factor following surgery for biliary atresia European Journal of Pediatric Surgery 18 1 22 25 10.1055/s-2008-1038326 18302065
3. Alves, G., Müller, B., Herlofson, K., Hogenesch, I., Telstad, W., Aarsland, D., et al. (2009). Incidence of Parkinson's disease in Norway. The Norwegian ParkWest study. Journal of Neurology, Neurosurgery, and Psychiatry [Epub ahead of print].
4. JG Anderson PT Cooney KM Erikson 2007 Inhibition of DAT function attenuates manganese accumulation in the globus pallidus Environmental Toxicology and Pharmacology 23 2 179 184 10.1016/j.etap.2006.08.006 17387379 (Pubitemid 46054507)
5. MB Antunes R Bowler RL Doty 2007 San Francisco/Oakland Bay Bridge Welder Study: Olfactory function Neurology 69 12 1278 1284 10.1212/01.wnl.0000276988. 50742.5e 17875916 (Pubitemid 47429029)
6. JL Aschner M Aschner 2005 Nutritional aspects of manganese homeostasis Molecular Aspects of Medicine 26 4-5 353 362 10.1016/j.mam.2005.07.003 16099026 (Pubitemid 41225358)
7. M Bouchard F Laforest L Vandelac D Bellinger D Mergler 2007 Hair manganese and hyperactive behaviors: Pilot study of school-age children exposed through tap water Environmental Health Perspectives 115 122 127 17366831
8. DB Calne NS Chu CC Huang CS Lu W Olanow 1994 Manganism and idiopathic Parkinsonism: Similarities and differences Neurology 44 9 1583 1586 7936278
9. E Canossa G Angiuli G Garasto A Buzzoni E De Rosa 1993 Dosage indicators in farm workers exposed to mancozeb La Medicina del lavoro 84 1 42 50 8492735
10. DA Cory-Slechta 2005 Studying toxicants as single chemicals: Does this strategy adequately identify neurotoxic risk? Neurotoxicology 26 4 491 510 10.1016/j.neuro.2004.12.007 16112317 (Pubitemid 41178971)
11. S Costello M Cockburn J Bronstein X Zhang B Ritz 2009 Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California American Journal of Epidemiology 169 8 919 926 10.1093/aje/kwp006 19270050
12. GC Cotzias 1958 Manganese in health and disease Physiological Reviews 38 503 532 13567045
13. J Couper 1837 On the effects of black oxide of manganese when inhaled into the lungs British Annals of Medicine and Pharmacology 1 41 42
14. DM Cowan Q Fan Y Zou X Shi J Chen M Aschner FS Rosenthal W Zheng 2009 Manganese exposure among smelting workers: Blood manganese-iron ratio as a novel tool for manganese exposure assessment Biomarkers 14 1 3 16 10.1080/13547500902730672 19283519
15. CP Curran RM Park S-m Ho EN Haynes 2008 Incorporating genetics and genomics in risk assessment for inhaled manganese: From data to policy Neurotoxicology 30 5 754 760 10.1016/j.neuro.2009.07.013
16. CJ da Silva AJ da Rocha S Jeronymo MF Mendes FT Milani AC Maia Jr FT Braga YA Sens LA Miorin 2007 A preliminary study revealing a new association in patients undergoing maintenance hemodialysis: Manganism symptoms and T1 hyperintense changes in the basal ganglia American Journal of Neuroradiology 28 8 1474 1479 10.3174/ajnr.A0600 17846194 (Pubitemid 47462930)
17. DC Dorman KA Brenneman AM McElveen SE Lynch KC Roberts BA Wong 2002 Olfactory transport: A direct route of delivery of inhaled manganese phosphate to the rate brain Journal of Toxicology and Environmental Health. Part A 65 20 1493 1511 10.1080/00984100290071630 12396865 (Pubitemid 35217497)
18. K Dörner S Dziadzka A Höhn E Sievers HD Oldigs G Schulz-Lell J Schaub 1989 Longitudinal manganese and copper balances in young infants and preterm infants fed on breastmilk and adapted cow's milk formulas British Journal of Nutrition 61 559 572 10.1079/BJN19890143 2758010
19. DL Edsall FP Wilbur CK Drinker 1919 The occurrence, course and prevention of chronic manganese poisoning Journal of Industrial Hygiene 1 183 193
20. A Elder R Glein V Silva T Feikert L Opanashuk J Carter R Potter A Maynard Y Ito J Finkelstein G Oberdorster 2006 Translocation of inhaled ultrafine manganese oxide particles to the central nervous system Environmental Health Perspectives 114 8 1172 1178 16882521
21. EPA. (2003). Health effects support document for manganese. EPA822R03003, U.S. Environmental Protection Agency, Washington DC. http://www.epa.gov/ safewater/ccl/pdfs/reg-determine1/support-cc1-magnese-healtheffects.pdf. Accessed 10 July 2009.
22. JM Fell AP Reynolds N Meadows K Khan SG Long G Quaghebeur WJ Taylor PJ Milla 1996 Manganese toxicity in children receiving long-term parenteral nutrition Lancet 347 9010 1218 1221 10.1016/S0140-6736(96)90735-7 8622451 (Pubitemid 26131849)
23. MM Finkelstein M Jerrett 2007 A study of the relationships between Parkinson's disease and markers of traffic-derived and environmental manganese air pollution in two Canadian cities Environmental Research 104 420 432 10.1016/j.envres.2007.03.002 17445792 (Pubitemid 46856358)
24. AD Gitler A Chesi ML Geddie KE Strathearn S Hamamichi KJ Hill KA Caldwell GA Caldwell AA Cooper JC Rochet S Lindquist 2009 Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity Nature Genetics 41 308 315 10.1038/ng.300 19182805
25. MS Golub CE Hogrefe SL Germann TT Tran JL Beard FM Crinella B Lonnerdal 2005 Neurobehavioral evaluation of rhesus monkey infants fed cow's milk formula, soy formula, or soy formula with added manganese Neurotoxicology and Teratology 27 4 615 627 10.1016/j.ntt.2005.04.003 15955660 (Pubitemid 41114884)
26. JM Gorell CC Johnson BA Rybicki EL Peterson GX Kortsha GG Brown RJ Richardson 1999 Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease Neurotoxicology 20 239 248 10385887
27. P Grandjean D Bellinger A Bergman S Cordier G Davey-Smith B Eskenazi D Gee K Gray M Hanson P van den Hazel J Heindel B Heinzow I Hertz-Picciotto H Hu T Huang T Kold Jensen PJ Landrigan IC McMillen K Murata B Ritz G Schoeters NE Skakkebæk S Skerfving P Weihe 2007 The Faroes Statement: Human health effects of developmental exposure to chemicals in our environment Basic & Clinical Pharmacology & Toxicology 102 2 73 75
28. P Grandjean P Landrigan 2006 Developmental neurotoxicity of industrial chemicals Lancet 368 9553 2167 2178 10.1016/S0140-6736(06)69665-7 17174709 (Pubitemid 44894541)
29. TR Guilarte MK Chen 2007 Manganese inhibits NMDA receptor channel function: Implications to psychiatric and cognitive effects Neurotoxicology 28 6 1147 1152 10.1016/j.neuro.2007.06.005 17662456 (Pubitemid 350026591)
30. R Gwiazda R Lucchini D Smith 2007 Adequacy and consistency of animal studies to evaluate the neurotoxicity of chronic low-level manganese exposure in humans Journal of Toxicology and Environmental Health. Part A 70 7 594 605 10.1080/10937400600882897 17365613 (Pubitemid 46328450)
31. Harper, P. S. (2002). Huntington's disease: A historical background. In G. Bates, P. S. Harper, & L. Jones (Eds.), Huntington's disease (3rd edn., pp. 3-24). Oxford: Oxford University Press. ISBN 0-19-851060-8.
32. Y Higashi M Asanuma I Miyazaki N Hattori Y Mizuno N Ogawa 2004 Parkin attenuates manganese-induced dopaminergic cell death Journal of Neurochemistry 89 1490 1497 10.1111/j.1471-4159.2004.02445.x 15189352 (Pubitemid 38802670)
33. CC Huang NS Chu CS Lu RS Chen M Schulzer DB Calne 2007 The natural history of neurological manganism over 18 years Parkinsonism & Related Disorders 13 3 143 145 10.1016/j.parkreldis.2006.09.002 (Pubitemid 46436560)
34. IEH/IOM. (2004). Institute for Environment and Health/Institute of Occupational Medicine Occupational exposure limits: Criteria document for manganese and inorganic manganese compounds (Web Report W17), Leicester, UK, MRC Institute for Environment and Health. http://www.le.ac.uk/ieh. Accessed 10 July 2009.
35. IUPAC. (1993). International Union of Pure and Applied Chemistry, Clinical Chemistry Division, Commission on Toxicology, Glossary for Chemists of Terms Used in Toxicology (IUPAC Recommendations 1993). Pure and Applied Chemistry, 65(9), 2003-2122.
36. T Jursa DR Smith 2009 Ceruloplasmin alters the tissue disposition and neurotoxicity of manganese, but not its loading onto transferrin Toxicological Sciences 107 1 182 193 10.1093/toxsci/kfn231 19005224
37. G Kenangil S Ertan I Sayilir S Ozekmekçi 2006 Progressive motor syndrome in a welder with pallidal T1 hyperintensity on MRI: A two-year follow-up Movement Disorders 21 12 2197 2200 10.1002/mds.21119 17013920 (Pubitemid 46140436)
38. Y Kim JW Kim K Ito HS Lim HK Cheong JY Kim YC Shin KS Kim Y Moon 1999 Idiopathic Parkinsonism with superimposed manganese exposure: Utility of positron emission tomography Neurotoxicology 20 2-3 249 252 10385888 (Pubitemid 29268569)
39. Y Kim KS Kim JS Yang IJ Park E Kim Y Jin KR Kwon KH Chang JW Kim SH Park HS Lim HK Cheong YC Shin J Park Y Moon 1999 Increase in signal intensities on T1-weighted magnetic resonance images in asymptomatic manganese-exposed workers Neurotoxicology 20 6 901 907 10693971
40. Y Kim JM Kim JW Kim CI Yoo CR Lee JH Lee HK Kim SO Yang HK Chung DS Lee B Jeon 2002 Dopamine transporter density is decreased in Parkinsonian patients with a history of manganese exposure: What does it mean? Movement Disorders 17 568 575 10.1002/mds.10089 12112209 (Pubitemid 36040973)
41. KJ Klos JE Ahlskog KA Josephs RD Fealey CT Cowl N Kumar 2005 Neurologic spectrum of chronic liver failure and basal ganglia T1 hyperintensity on magnetic resonance imaging: Probable manganese neurotoxicity Archives of Neurology 62 9 1385 1390 10.1001/archneur.62.9.1385 16157745 (Pubitemid 41352055)
42. TN Konstantinova OL Lakhman EV Katamanova NV Kartapol'tseva VA Meshcheriagin DV Rusanova OK Andreeva 2009 Clinical cases of occupational chronic manganese intoxication Meditsina truda i promyshlennaia ekologiia 1 27 31 19278189 in Russian
43. S Lesage A Brice 2009 Parkinson's disease: From monogenic forms to genetic susceptibility factors Human Molecular Genetics 18 R48 R59 10.1093/hmg/ddp012 19297401
44. GJ Li L Zhang L Lu P Wu W Zheng 2004 Occupational exposure to welding fume among welders: Alterations of manganese, iron, zinc, copper, and lead in body fluids and the oxidative stress status Journal of Occupational and Environmental Medicine 46 241 248 10.1097/01.jom.0000116900.49159.03 15091287 (Pubitemid 38366628)
45. KS Ljung MJ Kippler W Goessler GM Grandér BM Nermell ME Vahter 2009 Maternal and early life exposure to manganese in rural Bangladesh Environmental Science and Technology 43 7 2595 2601 10.1021/es803143z 19452922
46. K Ljung M Vahter 2007 Time to re-evaluate the guideline value for manganese in drinking water? Environmental Health Perspectives 115 1533 1538 18007980
47. Lönnerdal, B. (1994). Manganese nutrition of infants. In D. J. Klimis-Tavantzis (Ed.), Manganese in health and disease (pp. 176-191). Boca Raton, FL: CRC Press.
48. L Lu LL Zhang GJ Li W Guo W Liang W Zheng 2005 Serum concentrations of manganese and iron as the potential biomarkers for manganese exposure in welders Neurotoxicology 26 257 265 10.1016/j.neuro.2004.09.001 15713346 (Pubitemid 40248443)
49. R Lucchini E Albini L Benedetti S Borghesi R Coccaglio EC Malara G Parrinello S Garattini S Resola L Alessio 2007 High prevalence of Parkinsonian disorders associated to manganese exposure in the vicinities of ferroalloy industries American Journal of Industrial Medicine 50 788 800 10.1002/ajim.20494 17918215 (Pubitemid 350036017)
50. R Lucchini E Albini L Benedetti S Zoni A Caruso E Nan P Pasqualetti PM Rossini G Binetti L Benussi G Parrinello R Gasparotti A Padovani F Draicchio L Alessio 2007 Neurological and neuropsychological features in Parkinsonian patients exposed to neurotoxic metals Giornale Italiano di Medicina del Lavoro ed Ergonomia 29 280 281 18409686
51. R Lucchini E Bergamaschi A Smargiassi D Festa P Apostoli 1997 Motor function, olfactory threshold, and hematological indices in manganese-exposed ferroalloy workers Environmental Research 73 1-2 175 180 10.1006/enrs.1997.3702 9311544 (Pubitemid 27406579)
52. R Lucchini R Squitti E Albini L Benedetti S Borghesi E Nan F Draicchio R Coccaglio L Alessio 2008 Manganese exposure as a determinant of Parkinsonian damage Cell Biology and Toxicology 24 423 470 10.1007/s10565-008-9079-5
53. Lucchini, R., & Zimmerman, N. (2009). Lifetime cumulative exposure as a threat for neurodegeneration: Need for prevention strategies on a global scale. Neurotoxicology. doi: 10.1016/j.neuro.2009.10.003.
54. C Martin 2006 Manganese neurotoxicity: Connecting the dots along the continuum of dysfunction Neurotoxicology 27 347 349 10.1016/j.neuro.2005.11.002 16337002
55. G Meco V Bonifati N Vanacore E Fabrizio 1994 Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate) Scandinavian Journal of Work, Environment and Health 20 4 301 305 7801076
56. K Nelson J Golnick T Korn C Angle 1993 Manganese encephalopathy: Utility of early magnetic resonance imaging British Journal of Industrial Medicine 50 6 510 513 8329316
57. MC Newland B Weiss 1992 Persistent effects of manganese on effortful responding and their relationship to manganese accumulation in the primate globus pallidus Toxicology and Applied Pharmacology 113 87 97 10.1016/0041-008X(92)90012-H 1553759
58. ∅ygard, K., Riise, T., Moen, B., & Engelsen, B. A. (1992). Occurrence of Parkinson's disease (PD) and Parkinsonism (P) in Sauda community. Proceedings of the symposium on manganese toxicity (pp. 179-182). International Manganese Institute, Paris, France.
59. JD Park YH Chung CY Kim CS Ha SO Yang HS Khang IK Yu HK Cheong JS Lee CW Song IH Kwon JH Han JH Sung JD Heo BS Choi R Im J Jeong IJ Yu 2007 Comparison of high MRI T1 signals with manganese concentration in brains of cynomolgus monkeys after 8 months of stainless steel welding-fume exposure Inhalation Toxicology 19 965 971 10.1080/08958370701516108 17849280 (Pubitemid 350112227)
60. J Parkinson 2002 Neuropsychiatric classics: James Parkinson: An essay on the shaking palsy Journal of Neuropsychiatry and Clinical Neurosciences 14 223 236 11983801
61. DP Perl CW Olanow 2007 The neuropathology of manganese-induced Parkinsonism Journal of Neuropathology and Experimental Neurology 66 8 675 682 10.1097/nen.0b013e31812503cf 17882011 (Pubitemid 47344246)
62. MM Ponsen D Stoffers JW Twisk ECh Wolters HW Berendse 2009 Hyposmia and executive dysfunction as predictors of future Parkinson's disease: A prospective study Movement Disorders 24 7 1060 1065 10.1002/mds.22534 19353591
63. A Pratesi A Vella E Pasini F Salvi M Mascalchi 2008 Parkinsonism in polycythaemia vera probably due to manganism Movement Disorders 23 16 2420 2421 10.1002/mds.22319 18823038
64. BA Racette L McGee-Minnich SM Moerlein JW Mink TO Videen JS Perlmutter 2001 Welding-related Parkinsonism: Clinical features, treatment, and pathophysiology Neurology 56 8 13 11148228
65. BA Racette SD Tabbal D Jennings L Good JS Perlmutter B Evanoff 2005 Prevalence of Parkinsonism and relationship to exposure in a large sample of Alabama welders Neurology 64 2 230 235 15668418
66. BR Ritz AD Manthripragada S Costello SJ Lincoln MJ Farrer M Cockburn J Bronstein 2009 Dopamine transporter genetic variants and pesticides in Parkinson's disease Environmental Health Perspectives 117 6 964 969 19590691
67. Rodier, J. (1955). Manganese poisoning in Moroccan miners. British Journal of Industrial Medicine, 12.
68. JA Roth 2006 Homeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination Biological Research 39 45 57 10.4067/S0716-97602006000100006 16629164
69. Roth, J. A. (this issue). Are there common biochemical and molecular mechanisms controlling manganism and Parkinsonism? Neuromolecular Medicine. doi: 10.1007/s12017-009-8088-8.
70. JA Roth MD Garrick 2003 Iron interactions and other biological reactions medicating the physiological and toxic actions of manganese Biochemical Pharmacology 66 1 13 10.1016/S0006-2952(03)00145-X 12818360 (Pubitemid 36724894)
71. A Rovira J Alonso J Córdoba 2008 MR imaging findings in hepatic encephalopathy American Journal of Neuroradiology 29 9 1612 1621 10.3174/ajnr.A1139 18583413
72. AH Sadek R Rauch PE Schulz 2003 Parkinsonism due to manganism in a welder International Journal of Toxicology 22 393 401 14555414
73. HH Schaumburg S Herskovitz VA Cassano 2006 Occupational manganese neurotoxicity provoked by hepatitis C Neurology 67 2 322 323 10.1212/01.wnl.0000225179.21282.58 16864829 (Pubitemid 44305425)
74. P Schuler H Oyanguren V Maturana A Valenzuela E Cruz V Plaza E Schmidt R Haddad 1957 Manganese poisoning: Environmental and medical study at a Chilean mine Industrial Medicine and Surgery 26 167 173 13415693
75. H Shinotoh BJ Snow KA Hewitt BD Pate D Doudet R Nugent DP Perl W Olanow DB Calne 1995 MRI and PET studies of manganese-intoxicated monkeys Neurology 45 6 1199 1204 7783889
76. D Smith R Gwiazda R Bowler H Roels R Park C Taicher R Lucchini 2007 Biomarkers of manganese exposure in humans American Journal of Industrial Medicine 50 11 801 811 10.1002/ajim.20506 17924418 (Pubitemid 350036018)
77. LT Smyth RC Ruhf NE Whitman T Dugan 1973 Clinical manganism and exposure to manganese in the production and processing of ferromanganese alloy Journal of Occupational Medicine 15 2 101 109 4631080
78. R Squitti G Gorgone V Panetta R Lucchini S Bucossi E Albini, et al. 2009 Implications of metal exposure and liver function in Parkinsonian patients resident in the vicinities of ferroalloy plants Journal of Neural Transmission 116 10 1281 1287 10.1007/s00702-009-0283-0 19680597
79. MJ Stampfer 2009 Welding occupations and mortality from Parkinson's disease and other neurodegenerative diseases among United States men, 1985-1999 Journal of Occupational and Environmental Hygiene 6 5 267 272 10.1080/15459620902754703 19204865
80. A Stepens I Logina V Liguts P Aldins I Eksteina A Platkājis I Mārtinsone E Těrauds B Rozentāle M Donaghy 2008 A Parkinsonian syndrome in methcathinone users and the role of manganese New England Journal of Medicine 358 10 1009 1017 10.1056/NEJMoa072488 18322282 (Pubitemid 351347100)
81. K Thompson RM Molina T Donaghey JE Schwob JD Brain M Wessling-Resnick 2007 Olfactory uptake of manganese requires DMT1 and is enhanced by anemia FASEB Journal 21 1 223 230 10.1096/fj.06-6710com 17116743 (Pubitemid 46052560)
82. MA Verity 1999 Manganese neurotoxicity: A mechanistic hypothesis Neurotoxicology 20 489 497 10385907
83. L Verschoor AH Verschoor 2009 Work-related disease Nederlands tijdschrift voor geneeskunde 153 20 964 967 19490718 in Dutch
84. S Von Campenhausen B Bornschein R Wick K Botzel C Sampaio W Poewe W Oertel U Siebert K Berger R Dodel 2005 Prevalence and high prevalence of Parkinsonian disorders incidence of Parkinson's disease in Europe European Neuropsychopharmacology 15 473 490 10.1016/j.euroneuro.2005.04.007 (Pubitemid 40949553)
85. R Von Jaksch 1909 Ueber gehaufte diffuse Erkrankun- gen des Gehirns und Ruckenmarks, an den Typus der multiplen Sklerose mahnend, welche durch eine besondere Aetiologie gekennzeichnet sind Klein Rundsch 15 729 733 in German
86. JD Wang CC Huang YH Hwang JR Chiang JM Lin JS Chen 1989 Manganese induced Parkinsonism: An outbreak due to an unrepaired ventilation control system in a ferromanganese smelter British Journal of Industrial Medicine 46 856 859 2611159
87. GA Wasserman X Liu F Parvez H Ahsan D Levy P Factor-Litvak J Kline A van Geen V Slavkovich NJ LoIacono Z Cheng Y Zheng JH Graziano 2006 Water manganese exposure and children's intellectual function in Araihazar, Bangladesh Environmental Health Perspectives 114 124 129 16393669
88. B Weiss 2006 Economic implications of manganese neurotoxicity Neurotoxicology 27 3 362 368 10.1016/j.neuro.2005.03.011 15936082
89. Wexler, A. (2008). The woman who walked Into the sea. Huntington's and the making of a genetic disease (pp. 288). Yale University Press. ISBN 9780300105025.
90. WHO. (1981). Manganese. Environmental health criteria 17. Geneva, Switzerland: World Health Organization.
91. WHO. (2004). Manganese in drinking-water. Background document for development of WHO guidelines for drinking-water quality. World Health Organization. WHO/SDE/WSH/03.04/104. http://www.who.int/water-sanitation-health/ dwq/chemicals/manganese.pdf. Accessed 10 July 2009.
92. RO Wright C Amarasiriwardena AD Woolf R Jim DC Bellinger 2006 Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site Neurotoxicology 27 2 210 216 10.1016/j.neuro.2005.10.001 16310252 (Pubitemid 43216195)
93. AK Wright GW Arbuthnott 2007 The influence of the subthalamic nucleus upon the damage to the dopamine system following lesions of globus pallidus in rats European Journal of Neuroscience 26 3 642 648 10.1111/j.1460-9568.2007. 05706.x 17634067 (Pubitemid 47206804)
94. M Yamada S Ohno I Okayasu R Okeda S Hatakeyama H Watanabe K Ushio H Tsukagoshi 1986 Chronic manganese poisoning: A neuropathological study with determination of manganese distribution in the brain Acta Neuropathologica 70 3-4 273 278 10.1007/BF00686083 3766127
95. Yokel, R. A. (this issue). Manganese flux across the blood-brain barrier. Neuromolecular Medicine. doi: 10.1007/s12017-009-8101-2.
96. AR Zota AS Ettinger M Bouchard CJ Amarasiriwardena J Schwartz H Hu RO Wright 2009 Maternal blood manganese levels and infant birth weight Epidemiology 20 3 367 373 10.1097/EDE.0b013e31819b93c0 19289966