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Volumn 4, Issue 11, 2009, Pages 1930-1938

Synthesis and biological evaluation of chromium bioorganometallics based on the antibiotic platensimycin lead structure

Author keywords

Antibiotics; Antimicrobial resistance; Atomic absorption spectroscopy; Bioorganometallic chemistry; Chromium

Indexed keywords

CHROMIUM; PLATENSIMYCIN;

EID: 72949104190     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900347     Document Type: Article
Times cited : (59)

References (55)
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    • (2006) Concepts and Models in Bioinorganic Chemistry
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    • Crystallographic data of 14: C29H35CrNO 10, M, 609.58; monoclinic, P21/ c, a, 8.342(2, b, 57.10(1, c, 12.676(4, b, 95.662(9, V, 6010(3) Å3, Z, 8, R1, 0.0918 for 6829 observed (I>2s) reflections and wR2, 0.2309 for all 10 205 reflections, GOF, 1.038, 740 parameters. Brukeraxs-SMART 1000 CCD, structure solution with direct methods (SHELXS97, and refined against F2 with all measured reflections SHELXL97, Due to the long b axis the R1-value of structure refinement converged by 0.0918. CCDC 722266 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via
    • 2 with all measured reflections (SHELXL97). Due to the long b axis the R1-value of structure refinement converged by 0.0918. CCDC 722266 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data-request/cif.
  • 48
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    • At this stage, it should be noted that determination of a binding constant of 2 or 4 with the FabF enzyme was not possible, as, to the best of our knowledge no enzyme assay is currently commercially available or even published
    • At this stage, it should be noted that determination of a binding constant of 2 or 4 with the FabF enzyme was not possible, as, to the best of our knowledge no enzyme assay is currently commercially available or even published.
  • 49
    • 73449095970 scopus 로고    scopus 로고
    • Compound 5 could not be analyzed due to precipitation when B. subtilis was incubated with the compound at twice its MIC.
    • Compound 5 could not be analyzed due to precipitation when B. subtilis was incubated with the compound at twice its MIC.
  • 52
    • 73449090642 scopus 로고    scopus 로고
    • For new metal-containing Platensimycin analogues, a patent is pending (EP09154125).
    • For new metal-containing Platensimycin analogues, a patent is pending (EP09154125).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.