Using biointelligence to search the cancer genome: An epistemological perspective on knowledge recovery strategies to enable precision medical genomics

Oncogene

Volumn 27, Issue , 2008, Pages S58-S66

  Mousses, S ^a   Kiefer, J ^a   Von Hoff, D ^a   Trent, J ^a  

^a TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

Author keywords

Bioinformatics; Genomics; Intelligence; Ontology; Personalized medicine; Semantic

Indexed keywords

CANCER GENETICS; CONVALESCENCE; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; GENETIC ENGINEERING; GENOMICS; GENOTYPE; HEALTH CARE DELIVERY; HUMAN; INTELLIGENCE; PATIENT CARE; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

BIOMEDICAL RESEARCH; EVIDENCE-BASED MEDICINE; GENETICS, MEDICAL; GENOME, HUMAN; GENOMICS; HUMANS; MEDICAL INFORMATICS; MEDICAL ONCOLOGY; NEOPLASMS; PHARMACOGENETICS;

EID: 72949097291     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.354     Document Type: Review

References (20)

1. Brody JE. (2009). Buyer beware of home DNA tests. The New York Times. The New York Times Company: New York, p D6.
2. Chen H, Ding L, Wu Z, Yu T, Dhanapalan L, Chen JY. (2009). Semantic web for integrated network analysis in biomedicine. Brief Bioinform 10: 177-192.
3. Church GM. (2005). From systems biology to synthetic biology. Mol Syst Biol 1: 0030.
4. De Leo G, LeRouge C, Ceriani C, Niederman F. (2006). Websites most frequently used by physician for gathering medical information. AMIA Annu Symp Proc, p 902.
5. Dougherty ER. (2008). On the epistemological crisis in genomics. Curr Genomics 9: 69-79.
6. Fox EJ, Salk JJ, Loeb LA. (2009). Cancer genome sequencing-an interim analysis. Cancer Res 69: 4948-4950.
7. Guise TA, O'Keefe R, Randall RL, Terek RM. (2009). Molecular biology and therapeutics in musculoskeletal oncology. J Bone Joint Surg Am 91: 724-732.
8. Hawkins J, Blakeslee S. (2004). On Intelligence. Times Books: New York.
9. Kaye J. (2008). The regulation of direct-to-consumer genetic tests. Hum Mol Genet 17: R180-R183.
10. Klein RJ. (2007). Home-based technologies: a new paradigm for conducting dementia prevention trials. BMC Genet 8: 58.
11. Kurzweil R. (2005). The Singularity is Near: When Humans Transcend Biology. Viking: New York.
12. Li X, Quigg RJ, Zhou J, Gu W, Nagesh Rao P, Reed EF. (2008). Clinical utility of microarrays: current status, existing challenges and future outlook. Curr Genomics 9: 466-474.
13. Manning M, Aggarwal A, Gao K, Tucker-Kellogg G. (2009). Scaling the walls of discovery: using semantic metadata for integrative problem solving. Brief Bioinform 10: 164-176.
14. Powell IJ, Carpten J, Dunston G, Kittles R, Bennett J, Hoke G et al. (2001). African-American heredity prostate cancer study: a model for genetic research. J Natl Med Assoc 93: 25S-28S.
15. Qu XA, Gudivada RC, Jegga AG, Neumann EK, Aronow BJ. (2009). Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships. BMC Bioinformatics 10(Suppl 5): S4.
16. Ruttenberg A, Clark T, Bug W, Samwald M, Bodenreider O, Chen H et al. (2007). Advancing translational research with the Semantic Web. BMC Bioinform 8(Suppl 3): S2.
17. Schleutker J, Matikainen M, Smith J, Koivisto P, Baffoe-Bonnie A, Kainu T et al. (2000). genetic epidemiological study of hereditary prostate cancer (HPC) in Finland: frequent HPCX linkage in families with late-onset disease. Clin Cancer Res 6: 4810-4815.
18. Smith JR, Freije D, Carpten JD, Gronberg H, Xu J, Isaacs SD et al. (1996). Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science 274: 1371-1374.
19. Varmus H, Stillman B. (2005). Support for the Human Cancer Genome Project. Science 310: 1615.
20. Von Hoff DD, Stephenson JJ, Rosen PJ, Loesch DM, Borad MJ, Anthony SP et al. (2009). 100th Annual Meeting of the American Association for Cancer Research, Vol LB-259: Proceedings of the 100th Annual Meeting of the American Association for Cancer Research. AACR: Denver, CO.