Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: A randomized controlled trial

Malaria Journal

Volumn 8, Issue 1, 2009, Pages

  Nakibuuka, Victoria ^a,b   Ndeezi, Grace ^b   Nakiboneka, Deborah ^b   Ndugwa, Christopher M ^b   Tumwine, James K ^b  

^a Nsambya Hospital   (Uganda)

^b MAKERERE UNIVERSITY   (Uganda)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; FANSIDAR; ANTIMALARIAL AGENT; PYRIMETHAMINE; SULFADOXINE; SULFADOXINE-PYRIMETHAMINE;

ARTICLE; BLURRED VISION; CHILD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFICACY; FEMALE; FOLLOW UP; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALARIA; MALARIA CONTROL; MALE; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PREVALENCE; RANDOMIZED CONTROLLED TRIAL; RASH; SICKLE CELL ANEMIA; SKIN PRURITUS; TREATMENT OUTCOME; UGANDA; VOMITING; DRUG ADMINISTRATION; DRUG COMBINATION; INFANT; PARASITEMIA;

ANEMIA, SICKLE CELL; ANTIMALARIALS; CHILD; CHILD, PRESCHOOL; CHLOROQUINE; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FEMALE; HUMANS; INFANT; MALARIA; MALE; PARASITEMIA; PYRIMETHAMINE; SULFADOXINE; TREATMENT OUTCOME; UGANDA;

EID: 72849140348     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-8-237     Document Type: Article

References (26)

1. Disorders of the blood in paediatrics in the Tropics. RG Hendricks ED Hendricks DG Matthew, Blackwell Scientific Publications, London 1991 336 72
2. Analysis of the effects of malaria chemoprophylaxis in children on haematological responses, morbidity and mortality. D Paul J Bernard P Geerlings J Bernard Brabin A Teunis Eggelete, Bull World Health Organ 2003 81 205 216
3. Sickle cell disease in Uganda: a time for action. S Graham CM Ndugwa, East Afr Med J 2003 80 384 387
4. World Health Organization, Prevalence of sickle cell disease WHO, Geneva 2005
5. Mortality from Sickle cell Disease in Africa. G Serjeant, BMJ 2005 330 432 433
6. G Serjeant, The geography of sickle cell disease 1994
7. Clinical Evidence Sickle Cell Disease. M Meremikwu, BMJ 2009 http://clinicalevidence.bmj.com/ceweb/conditions/bly/2402/2402.jsp
8. Types of anaemic crises in paeditric patients with sickle cell anaemia seen in Enugu, Nigeria. A Jumah E Nlemadim W Kaine, Arch Dis Childhood 2004 89 572 576
9. Causes of death among sickle cell anaemia patients at Mulago Hospital, Kampala, Uganda. Kagwa- Nyanzi, East Afr Med J 1970 47 338 343
10. Chemoprophylaxis of homozygous sicklers with antimalarials and long acting penicillin. MA Warley DJS Hamilton PD Marsden RE Brown JG Merselis N Wilks, BMJ 1965 5453 86 88
11. Sulfadoxine/pyrimethamine alone or amodiaquine or artesunate for treatment of uncomplicated malaria. G Dorsey M Kamya D Njama A Cattamanchi D Kyabayinze A Gasasira PJ Rosenthal, Lancet 2002 360 2031 38
12. Clinical efficacy of chloroquine or sulfadoxine - pyrimethamine in children under five from south- western Uganda with uncomplicated falciparum malaria. D Legros K Johnson P Houpiklan M Makanga JK Kabakyenga WR Taylor, Trans R Soc Trop Med Hyg 2004 96 199 201
13. Chloroquine chemoprophylaxis in children during peak transmission period in Ethiopia. B Wolde J Pickering K Wotton, J Trop Med Hyg 1994 97 215 218
14. A Kamugisha, Prevalence and factors associated with aplastic crises in sickle cell anaemia children at Mulago Hospital Makerere University, Dissertation 2005
15. Intermittent treatment for malaria and anaemia control at the time of routine vaccination in the Tanzanian infants, randomized, placebo controlled trial. D Schellenberg C Menendez J Elizeus Kahigwa Aponte J Vidal T Marcel H Mshinda P Alonso, Lancet 2001 357 1471 1477
16. The promise and challenges of intermittent preventive treatment for malaria. WP O'Meara JG Breman FE Mckenzie, Malar J 2005 4 1475 2875
17. Treatment of malaria restricted to Laboratory confirmed cases: a prospective cohort in Ugandan children. D Njama-Meya TD Clark S Nzarubara B Staedke M Kamya, Malar J 2007 6 7
18. Intermittent treatment for malaria and anaemia control at the time of routine vaccination in the Tanzanian infants Randomised placebo controlled trial. D Schellenberg C Menendez E Kahigwa, Lancet 2001 57 1471 1477
19. Chloroquine and chloroguanide as suppressants of malaria in Guatemala. CG Dobrovolny WC White GR Coaey, Am J Trop Med Hyg 1953 12 808 845
20. Cluster randomized trial of intermittent preventive treatment for malaria in infants in area of high seasonal transmision in Ghana. D Chandramohan S Owusu I Carnerio T Awine K Amponsa N Mensah S Jaffar R Baiden A Hodgson F Binka B Green Wood, BMJ 2005 331 727 733
21. Intermittent presumptive treatment for malaria. NJ White, PLoS Med 2005 2 3
22. Intermittent preventive treatment for malaria control in infants moving towards evidence based policy and public health action. A Egan J Crawley D Schellenberg, Trop Med Int Health 2005 10 815 817
23. Increasing anti malarial drug resistance in Uganda and revision of the national drug policy. M Kamya NN Bakyaita AO Talisuna WM Were SG Staedke, Trop Med Int Health 2002 7 1031 1041
24. High prevalence of drug resistance mutations in Plasmodium falciparum and P lasmodium vivax in southern Ethiopia. S Mirjam P Wondimagegn B Isabel E Maha S Roewer A Alano T Loscher B Ulrich F Mockenhaupt, Malar J 2006 5 54
25. Impact of trimethoprim-sulfamethoxazole prophylaxis on falciparum malaria infection and disease. A Mahamadou MA Thera S Paul D Coulibaly K Traore MN Garba Y Cissoko A Kone A Guindo A Dicko AH Baevoqui A Djimde KE Lyke DA Diallo OK Doumbo CV Plowe, J Infect Dis 2005 192 1823 1829
26. Effects of pyrimethamine versus proguanil in malarial chemprophyalaxis in children with sickle cell disease, a randomized placebo controlled pen label study. U Felicia E Ifeoma, Curr Ther Res Clin E 2003 64 616 625