Specific inhibition of HCN channels slows rhythm differently in atria, ventricle and outflow tract and stabilizes conduction in the anoxic-reoxygenated embryonic heart model

Pharmacological Research

Volumn 61, Issue 1, 2010, Pages 85-91

  Sarre, Alexandre ^a   Pedretti, Sarah ^a   Gardier, Stephany ^a   Raddatz, Eric ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Anoxia reoxygenation; Electrocardiogram; Embryo; HCN channels; Heart; Ivabradine

Indexed keywords

CATION CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 4; IVABRADINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CHICK; CONTROLLED STUDY; ELECTROCARDIOGRAM; EMBRYO; EXCITATION CONTRACTION COUPLING; HEART ATRIUM; HEART BEAT; HEART MUSCLE CONDUCTION DISTURBANCE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART RHYTHM; HEART VENTRICLE; ISOLATED HEART; NONHUMAN; PR INTERVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QT INTERVAL; REOXYGENATION; TISSUE DISTRIBUTION;

ANIMALS; ANOXIA; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; BENZAZEPINES; BIOLOGICAL CLOCKS; BLOTTING, WESTERN; CHICK EMBRYO; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; EXCITATION CONTRACTION COUPLING; HEART; HEART ATRIA; HEART CONDUCTION SYSTEM; HEART RATE; HEART VENTRICLES; MYOCARDIAL CONTRACTION; OXYGEN; POTASSIUM CHANNELS; TIME FACTORS; TISSUE CULTURE TECHNIQUES;

EID: 72749090082     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.09.007     Document Type: Article

References (33)

1. Bucchi A., Barbuti A., Baruscotti M., and Difrancesco D. Heart rate reduction via selective 'funny' channel blockers. Curr Opin Pharmacol 7 (2007) 208-213
2. Siu C.W., Lieu D.K., and Li R.A. HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering. J Membr Biol 214 (2006) 115-122
3. DiFrancesco D., and Camm J.A. Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease. Drugs 64 (2004) 1757-1765
4. Bois P., Bescond J., Renaudon B., and Lenfant J. Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells. Br J Pharmacol 118 (1996) 1051-1057
5. Berdeaux A. Preclinical results with I(f) current inhibition by ivabradine. Drugs 67 Suppl. 2 (2007) 25-33
6. Ferrari R., Cargnoni A., and Ceconi C. Anti-ischaemic effect of ivabradine. Pharmacol Res 53 (2006) 435-439
7. Vilaine J.P. The discovery of the selective I(f) current inhibitor ivabradine A new therapeutic approach to ischemic heart disease. Pharmacol Res 53 (2006) 424-434
8. Mommersteeg M.T., Hoogaars W.M., Prall O.W., de Gier-de Vries C., Wiese C., Clout D.E., et al. Molecular pathway for the localized formation of the sinoatrial node. Circ Res 100 (2007) 354-362
9. Stieber J., Herrmann S., Feil S., Loster J., Feil R., Biel M., et al. The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci USA 100 (2003) 15235-15240
10. Harzheim D., Pfeiffer K.H., Fabritz L., Kremmer E., Buch T., Waisman A., et al. Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP. EMBO J 27 (2008) 692-703
11. Kamino K., Hirota A., and Fujii S. Localization of pacemaking activity in early embryonic heart monitored using voltage-sensitive dye. Nature 290 (1981) 595-597
12. Van Mierop L.H. Location of pacemaker in chick embryo heart at the time of initiation of heartbeat. Am J Physiol 212 (1967) 407-415
13. Satoh H., and Sperelakis N. Identification of the hyperpolarization-activated inward current in young embryonic chick heart myocytes. J Dev Physiol 15 (1991) 247-252
14. Satoh H., and Sperelakis N. Hyperpolarization-activated inward current in embryonic chick cardiac myocytes: developmental changes and modulation by isoproterenol and carbachol. Eur J Pharmacol 240 (1993) 283-290
15. Yasui K., Liu W., Opthof T., Kada K., Lee J.K., Kamiya K., et al. I(f) current and spontaneous activity in mouse embryonic ventricular myocytes. Circ Res 88 (2001) 536-542
16. Sarre A., Maury P., Kucera P., Kappenberger L., and Raddatz E. Arrhythmogenesis in the developing heart during anoxia-reoxygenation and hypothermia-rewarming: an in vitro model. J Cardiovasc Electrophysiol 17 (2006) 1350-1359
17. Rosa A., Maury J.P., Terrand J., Lyon X., Kucera P., Kappenberger L., et al. Ectopic pacing at physiological rate improves postanoxic recovery of the developing heart. Am J Physiol Heart Circ Physiol 284 (2003) H2384-H2392
18. Hamburger V., and Hamilton H. A series of normal stages in the development of the chick embryo. J Morphol 88 (1951) 49-92
19. Sarre A., Lange N., Kucera P., and Raddatz E. mitoKATP channel activation in the postanoxic developing heart protects E-C coupling via NO-, ROS-, and PKC-dependent pathways. Am J Physiol Heart Circ Physiol 288 (2005) H1611-H1619
20. Bucchi A., Tognati A., Milanesi R., Baruscotti M., and Difrancesco D. Properties of ivabradine-induced block of HCN1 and HCN4 channels. J Physiol 572 (2006) 335-346
21. El Chemaly A., Magaud C., Patri S., Jayle C., Guinamard R., and Bois P. The heart rate-lowering agent ivabradine inhibits the pacemaker current I in human atrial myocytes. J Cardiovasc Electrophysiol 18 (2007) 1190-1196
22. Shepherd N., Graham V., Trevedi B., and Creazzo T.L. Changes in regulation of sodium/calcium exchanger of avian ventricular heart cells during embryonic development. Am J Physiol Cell Physiol 292 (2007) C1942-C1950
23. Mery A., Aimond F., Menard C., Mikoshiba K., Michalak M., and Puceat M. Initiation of embryonic cardiac pacemaker activity by inositol 1,4,5-trisphosphate-dependent calcium signaling. Mol Biol Cell 16 (2005) 2414-2423
24. Yang H.T., Tweedie D., Wang S., Guia A., Vinogradova T., Bogdanov K., et al. The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development. Proc Natl Acad Sci USA 99 (2002) 9225-9230
25. Thollon C., Bidouard J.P., Cambarrat C., Lesage L., Reure H., Delescluse I., et al. Stereospecific in vitro and in vivo effects of the new sinus node inhibitor (+)-S 16257. Eur J Pharmacol 339 (1997) 43-51
26. Park K., Lee S., Kang S.J., Choi S., and Shin K.S. Hyperpolarization-activated currents control the excitability of principal neurons in the basolateral amygdala. Biochem Biophys Res Commun 361 (2007) 718-724
27. Veenstra R.D. Developmental changes in regulation of embryonic chick heart gap junctions. J Membr Biol 119 (1991) 253-265
28. Wiens D., Jensen L., Jasper J., and Becker J. Developmental expression of connexins in the chick embryo myocardium and other tissues. Anat Rec 241 (1995) 541-553
29. Romano R., Rochat A.C., Kucera P., De Ribaupierre Y., and Raddatz E. Oxidative and glycogenolytic Capacities within the developing chick heart. Pediatr Res 49 (2001) 363-372
30. Stieber J., Wieland K., Stockl G., Ludwig A., and Hofmann F. Bradycardic and proarrhythmic properties of sinus node inhibitors. Mol Pharmacol 69 (2006) 1328-1337
31. Brioschi C., Micheloni S., Tellez J.O., Pisoni G., Longhi R., Moroni P., et al. Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node. J Mol Cell Cardiol 47 (2009) 221-227
32. Garcia-Frigola C., Shi Y., and Evans S.M. Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development. Gene Expr Patterns 3 (2003) 777-783
33. Whitaker G.M., Angoli D., Nazzari H., Shigemoto R., and Accili E.A. HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. J Biol Chem 282 (2007) 22900-22909