The heart rate-lowering agent ivabradine inhibits the pacemaker current If in human atrial myocytes

Journal of Cardiovascular Electrophysiology

Volumn 18, Issue 11, 2007, Pages 1190-1196

  El Chemaly, Antoun ^a   Magaud, Christophe ^a   Patri, Sylvie ^a   Jayle, Christophe ^a   Guinamard, Romain ^a   Bois, Patrick ^a  

^a UNIVERSITÉ DE POITIERS   (France)

Author keywords

Atrial arrhythmias; HCN; Human atrial myocytes; Ivabradine; Multiplex single cell RT PCR; Whole cell patch clamp

Indexed keywords

CYCLIC AMP; IVABRADINE;

ARTICLE; ATRIAL MYOCYTE; CHANNEL GATING; DRUG EFFECT; DRUG INHIBITION; HEART MUSCLE; HUMAN; HUMAN TISSUE; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; IC 50; PACEMAKER ELECTRODE; PATCH CLAMP; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BENZAZEPINES; CARDIAC PACING, ARTIFICIAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART ATRIA; HUMANS; MODELS, ANIMAL; MYOCYTES, CARDIAC; PACEMAKER, ARTIFICIAL; PATCH-CLAMP TECHNIQUES; RABBITS;

EID: 35348984848     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/j.1540-8167.2007.00955.x     Document Type: Article

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