Single and multiple-dose pharmacokinetics of meloxicam after oral administration to the rabbit (Oryctolagus cuniculus)

Journal of Zoo and Wildlife Medicine

Volumn 40, Issue 4, 2009, Pages 601-606

  Carpenter, James W ^a   Pollock, Christal G ^a,b   Koch, David E ^a   Hunter, Robert P ^a,c  

^a KANSAS STATE UNIVERSITY   (United States)

^b Veterinary Safety/ADME ^*  (United States)

^c ELANCO ANIMAL HEALTH   (United States)

Author keywords

Meloxicam; Nonsteroidal anti inflammatory drug; Oryctolagus cuniculus; Pharmacokinetics; Rabbit

Indexed keywords

MELOXICAM; NONSTEROID ANTIINFLAMMATORY AGENT; THIAZINE DERIVATIVE; THIAZOLE DERIVATIVE;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BLOOD; DRUG ADMINISTRATION; FEMALE; HALF LIFE TIME; ORAL DRUG ADMINISTRATION; RABBIT;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; DRUG ADMINISTRATION SCHEDULE; FEMALE; HALF-LIFE; RABBITS; THIAZINES; THIAZOLES;

ORYCTOLAGUS CUNICULUS;

EID: 72649092896     PISSN: 10427260     EISSN: None     Source Type: Journal    
DOI: 10.1638/2007-0115.1     Document Type: Article

References (33)

1. Adams, H. R. (ed.). 2001. Veterinary Pharmacology and Therapeutics, 8th ed. Iowa State Univ. Press, Ames, Iowa.
2. Baert, K., and P. De Backer. 2003. Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species. Comp. Biochem. Physiol. Part C 134: 25-33.
3. Bays, T. B. 2006. Rabbit behavior. In: Bays, T. B., T. Lightfoot, and J. Mayer (eds.). Exotic Pet Behavior: Birds, Reptiles, and Small Mammals. Saunders Elsevier, St. Louis, Missouri. Pp. 41-43.
4. Boxenbaum, H., and C. DiLea. 1995. First-timein- human dose selection: Allometric thoughts and perspectives. J. Clin. Pharmacol. 35: 957-966.
5. Brodie, B. B., and W. D. Reid. 1967. Some pharmacological consequences of species variation in rates of metabolism. Fed. Proc. 26: 1062-1070.
6. Burgos-Vargas, R., I. Foeldvari, A. Thon., R. Linke, and D. Tuerck. 2004. Pharmacokinetics of meloxicam in patients with juvenile rheumatoid arthritis. J. Clin. Pharmacol. 44: 866-872.
7. Burian, M., and G. Geisslinger. 2005. COXdependent mechanisms involved in the antinociceptive action of NSAIDs at central and peripheral sites. Pharmacol. Ther. 107: 139-154.
8. Busch, U., J. Schmid, G. Heinzel, H. Schmaus, J. Baierl, C. Huber, and W. Roth. 1998. Pharmacokinetics of meloxicam in animals and the relevance to humans. Drug Metab. Disposition 26: 576-584.
9. Carpenter, J. W. (ed.). 2005. Exotic Animal Formulary, 3rd ed. Elsevier Inc., St. Louis, Missouri. Pp. 432-434.
10. Carpenter, J. W. 2006. Diagnosing and treating common neurologic diseases in rabbits. Vet. Med. 101: 728-736.
11. Carroll, G. L., and S. M. Simonson. 2005. Recent developments in nonsteroidal anti-inflammatory drugs in cats. J. Am. Anim. Hosp. Assoc. 41: 347-354.
12. Gassel, A. D., K. M. Tobias, C. M. Egger, and B. W. Rohrbach. 2005. Comparison of oral and subcutaneous administration of buprenorphine and meloxicam for preemptive analgesia in cats undergoing ovariohysterectomy. J. Am. Vet. Med. Assoc. 227: 1937-1944.
13. Gates, B. J., T. T. Nguyen, S. M. Stetter, and N. M. Davies. 2005. Meloxicam: A reappraisal of pharmacokinetics, efficacy and safety. Expert. Opin. Pharmacother. 6: 2117-2140.
14. Gibaldi, M., and P. Perrier. 1982. Pharmacokinetics, 2nd ed. Marcel Dekker, New York, New York. Pp. 409-417.
15. Hunter, R. P., and R. Isaza. 2008. Concepts and issues with interspecies scaling in zoological medicine. J. Zoo Wild. Med. 39: 517-526.
16. Hunter, R. P., I. Mahmood, and M. N. Martinez. 2008. Prediction of xenobiotic clearance in avian species using mammalian data: How accurate is the prediction? J. Vet. Pharmacol. Ther. 31: 281-284.
17. Jones, C. J., and S. C. Budsberg. 2000. Physiologic characteristics and clinical importance of the cyclooxygenase isoforms in dogs and cats. J. Am. Vet. Med. Assoc. 717: 721-729.
18. Luna, S. P. L., A. C. Basílio, P. V. M. Steagall, L. P. Machado, F. Q. Moutinho, R. K. Takahira, and C. V. S. Brandão. 2007. Evaluation of adverse effects of long-term oral administration of carprofen, edodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs. Am. J. Vet. Res. 68: 258-264.
19. Mahmood, I. 2007. Application of allometric principles for the prediction of pharmacokinetics in human and veterinary drug development. Adv. Drug Del. Rev. 59: 1177-1192.
20. Mahmood, I., and J. D. Balian. 1999. The pharmacokinetic principles behind scaling from preclinical results to phase I protocols. Clin. Pharmacokinet. 36: 1-11.
21. Mahmood, I., M. Martinez, and R. P. Hunter. 2006. Interspecies allometric scaling. Part I: Prediction of clearance in large animals. J. Vet. Pharmacol. Ther. 29: 415-423.
22. Martinez, M., I. Mahmood, and R. P. Hunter. 2006. Interspecies allometric scaling: Prediction of clearance in large animal species: Part II: Mathematical considerations. J. Vet. Pharmacol. Ther. 29: 425-432.
23. Noble, S., and J. A. Balfour. 1996. Meloxicam. Drugs 51: 424-430.
24. Paulson, S. K., M. B. Vaughn, S. M. Jessen, Y. Lawal, C. J. Gresk, B. Yan, T. J. Maziasz, C. S. Cook, and A. Karim. 2001. Pharmacokinetics of celecoxib after oral administration in dogs and humans: Effect of food and site of absorption. J. Pharmacol. Exp. Ther. 297: 638-645.
25. Plumb, D. C. Veterinary Drug Handbook, 4th ed. 2002. Iowa State Univ. Press, Ames, Iowa.
26. Riviere, J. E. 1999. Comparative Pharmacokinetics: Principles, Techniques, and Applications. Iowa State Univ. Press, Ames, Iowa. Pp. 148-167.
27. Roughan, J. V., and P. A. Flecknell. 2003. Evaluation of a short duration behavior-based postoperative pain scoring system in rats. Europ. J. Pain 7: 397-406.
28. Salhab, A. S., B. I. Amro, and M. S. Shomaf. 2003. Further investigation on meloxicam contraceptivity in female rabbits: Luteinizing unruptured follicles, a microscopic evidence. Contraception 67: 485-489.
29. Salhab, A. S., M. N. Gharaibeh, M. S. Shomaf, and B. I. Amro. 2001. Meloxicam inhibits rabbit ovulation. Contraception 63: 329-333.
30. Schmidt, H., and A. Banting. 2000. Meloxicam (MetacamH) for the alleviation of inflammatory conditions in swine-selection of an effective dose. Proc. 16th Int. Pig Vet. Soc. Congr., Melbourne, Australia: 99.
31. Slingsby, L. S., and A. E. Waterman-Pearson. Postoperative analgesia in the cat after ovariohysterectomy by use of carprofen, ketoprofen, meloxicam or tolfenamic acid. J. Small Anim. Pract. 41: 447-450.
32. Turner, P. V., H. C. Chen, and W. M. Taylor. 2006. Pharmacokinetics of meloxicam in rabbits after single and repeat oral dosing. Comp. Med. 56: 63-67.
33. Turner, P. V., C. L. Kerr, A. J. Healy, and W. M. Taylor. 2006. Effect of meloxicam and butorphanol on minimum alveolar concentration of isoflurane in rabbits. Am. J. Vet. Res. 67: 770-774.