Dose-dependent effects of the CRF1 receptor antagonist R317573 on regional brain activity in healthy male subjects

Psychopharmacology

Volumn 208, Issue 1, 2010, Pages 109-119

  Schmidt, Mark E ^a   Andrews, Randolph D ^b   Van Der Ark, Peter ^a   Brown, Terry ^b   Mannaert, Erik ^a   Steckler, Thomas ^a   De Hoon, Jan ^c   Van Laere, Koen ^c  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b Abiant Inc   (United States)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Brain glucose metabolism; CRF1 antagonist; FDG PET; Human

Indexed keywords

CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; FLUORODEOXYGLUCOSE F 18; PLACEBO; R 317573; UNCLASSIFIED DRUG;

ADULT; AMYGDALOID NUCLEUS; AREA UNDER THE CURVE; ARTICLE; BRAIN FUNCTION; BRAIN METABOLISM; BRAIN REGION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG INDUCED HEADACHE; FRONTAL CORTEX; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; SINGLE DRUG DOSE; SOMNOLENCE; SUBICULUM; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADULT; BRAIN; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, RADIATION; DOUBLE-BLIND METHOD; FLUORODEOXYGLUCOSE F18; GLUCOSE; HUMANS; MALE; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; YOUNG ADULT;

EID: 72649089526     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-009-1714-1     Document Type: Article

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