Interaction of arylsulfatase-A (ASA) with its natural sulfoglycolipid substrates: A computational and site-directed mutagenesis study

Glycoconjugate Journal

Volumn 26, Issue 8, 2009, Pages 1029-1045

  Schenk, Matthias ^a,b   Koppisetty, Chaitanya A K ^b   Santos, Daniela Costa ^a   Carmona, Euridice ^c   Bhatia, Smita ^d   Nyholm, Per Georg ^e   Tanphaichitr, Nongnuj ^a,f  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b BIOGNOS AB   (Sweden)

^c UNIVERSITY OF MONTREAL   (Canada)

^d NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^e UNIVERSITY OF GOTHENBURG   (Sweden)

^f UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Arylsulfatase A; Enzyme substrate interaction; Galactosyl sulfate; PK a calculation; Structural docking; Sulfatase; Sulfogalactosylceramide; Sulfogalactosylglycerolipid

Indexed keywords

4 NITROCATECHOL; ALANINE; CEREBROSIDE SULFATASE; CYSTEINE; GALACTOSYLCERAMIDE; GLYCEROLIPID; HYDROGEN; LYSINE; SULFATE; SULFATIDE;

ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME BINDING; FEMALE; HYDROGEN BOND; MALE; MAMMAL CELL; MOLECULAR DOCKING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACIDS; ANIMALS; CARBOHYDRATE CONFORMATION; CATALYTIC DOMAIN; CEREBROSIDE-SULFATASE; CHO CELLS; CHROMATOGRAPHY, THIN LAYER; COMPUTATIONAL BIOLOGY; CRICETINAE; CRICETULUS; GLYCOLIPIDS; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY; SULFATES; SUS SCROFA;

EID: 72649086457     PISSN: 02820080     EISSN: 15734986     Source Type: Journal    
DOI: 10.1007/s10719-008-9222-9     Document Type: Article

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