Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans

Science

Volumn 326, Issue 5955, 2009, Pages 994-998

  Kim, Kyuhyung ^a   Sato, Koji ^b   Shibuya, Mayumi ^a   Zeiger, Danna M ^a   Butcher, Rebecca A ^c   Ragains, Justin R ^c   Clardy, Jon ^c   Touhara, Kazushige ^b   Sengupta, Piali ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCAROSIDE C3; ASCAROSIDE C6; ASCAROSIDE C7; ASCAROSIDE C9; DAUER PHEROMONE; G PROTEIN COUPLED RECEPTOR; GLYCOSIDE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PHEROMONE DERIVATIVE; PHEROMONE RECEPTOR; UNCLASSIFIED DRUG;

CHEMICAL CUE; CHEMORECEPTION; LARVA; MOLECULAR ANALYSIS; NEMATODE; PHEROMONE;

ARTICLE; CAENORHABDITIS ELEGANS; CHEMORECEPTOR; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; INSECT DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORY NERVE CELL;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CALCIUM; CELL LINE; CHEMORECEPTOR CELLS; CYCLIC AMP; CYCLIC GMP; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HELMINTH; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANYLATE CYCLASE; HEXOSES; HUMANS; MUTATION; PHEROMONES; RECEPTORS, G-PROTEIN-COUPLED; REPRODUCTION; SIGNAL TRANSDUCTION; TRANSFECTION;

CAENORHABDITIS; CAENORHABDITIS ELEGANS;

EID: 72449211854     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1176331     Document Type: Article

References (28)

1. P. Karlson, M. Lüscher, Nature 183, 55 (1959).
2. T. S. Wyatt, Pheromones and Animal Behavior: Communication by Smell and Taste (Cambridge Univ. Press, Cambridge, 2003).
3. J. W. Golden, D. L Riddle, Dev. Biol. 102, 368 (1984).
4. J. W. Golden, D. L Riddle, Science 218, 578 (1982).
5. E. Z. Macosko et al., Nature 458, 1171 (2009).
6. J. Srinivasan et al., Nature 454, 1115 (2008).
7. P.-Y. Jeong et al., Nature 433, 541 (2005).
8. R. A. Butcher, J. R. Ragains, E. Kim, J. Clardy, Proc. Natl. Acad. Sci. USA. 105, 14288 (2008).
9. R. A. Butcher, M. Fujita, F. C. Schroeder, J. Clardy, Nat. Chem. Biol. 3, 420 (2007).
10. Materials and methods are available as supporting material on Science Online.
11. J. H. Thomas, H. R. Robertson, BMC Biol. 6, 42 (2008).
12. W. S. Schackwitz, T. Inoue, J. H. Thomas, Neuron 17, 719 (1996).
13. P. Ren et al., Science 274, 1389 (1996).
14. E. L. Peckol, E. R. Troemel, C. I. Bargmann, Proc. Natl. Acad. Sci. U.S.A. 98, 11032 (2001).
15. K. M. Nolan, T. R. Sarafi-Reinach, J. G. Home, A. M. Saffer, P. Sengupta, Genes Dev. 16, 3061 (2002).
16. E. R. Troemel, J. H. Chou, N. D. Dwyer, H. A. Colbert, C. I. Bargmann, Cell 83, 207 (1995).
17. D. A. Birnby et al., Genetics 155, 85 (2000).
18. M. Murakami, M. Koga, Y. Ohshima, Mech. Dev. 109, 27 (2001).
19. R. R. Zwaal, J. E. Mendel, P. W. Sternberg, R. H. Plasterk, Genetics 145, 715 (1997).
20. A. E. Alewijnse et al., FEBS Lett. 419, 171 (1997).
21. A. Kurtovic, A. Widmer, B. J. Dickson, Nature 446, 542 (2007).
22. C. M. Grozinger, N. M. Sharabash, C. W. Whitfield, G. E. Robinson, Proc. Natl. Acad. Sci. U.S.A. 100, (suppl. 2), 14519 (2003).
23. C. Alaux et al., Genes Brain Behav. 8, 309 (2009).
24. W. E. Grus, J. Zhang, Mol. Biol. Evol. 25, 1593 (2008).
25. W. Li, S. G. Kennedy, G. Ruvkun, Genes Dev. 17, 844 (2003).
26. N. A. Bishop, L. Guarente, Nature 447, 545 (2007).
27. P. Dowell, Z. Hu, M. D. Lane, Annu. Rev. Biochem. 74, 515 (2005).
28. We are grateful to E. Macosko, C. Bargmann, J. Thomas, and R. Shingai for advice, assistance, and reagents. We thank the Caenorhabditis Genetics Center and S. Mitani for strains, members of the Sengupta lab and P. Garrity for discussion, and C. Li for critical comments. This work was supported by NSF (IOS 0542372 to P.S.), NIH (R01 GM56223 to P.S., P30 NS45713, R01 CA24487 to J.C., and F32 GM077943 to R.A.B.), and the Ministry of Education, Science, Sports, and Culture, Japan (K.T.).