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Volumn 94, Issue 2, 2004, Pages 175-183

Perlecan-Induced Suppression of Smooth Muscle Cell Proliferation Is Mediated Through Increased Activity of the Tumor Suppressor PTEN

Author keywords

Basement membrane; Restenosis; Smooth muscle cell proliferation; Vascular development; Vascular injury

Indexed keywords

COMPLEMENTARY DNA; DNA; FIBRONECTIN; FOCAL ADHESION KINASE; MORPHOLINE; PERLECAN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P27;

EID: 1042302787     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000109791.69181.B6     Document Type: Article
Times cited : (49)

References (45)
  • 1
    • 0028063933 scopus 로고
    • Developmentally timed expression of an embryonic growth phenotype in vascular smooth muscle cells
    • Cook CL, Weiser MCM, Schwartz PE, Jones CL, Majack RA. Developmentally timed expression of an embryonic growth phenotype in vascular smooth muscle cells. Circ Res. 1994;74:189-196.
    • (1994) Circ Res , vol.74 , pp. 189-196
    • Cook, C.L.1    Weiser, M.C.M.2    Schwartz, P.E.3    Jones, C.L.4    Majack, R.A.5
  • 2
    • 0020520943 scopus 로고
    • Kinetics of cellular proliferation after arterial injury, I: Smooth muscle growth in the absence of endothelium
    • Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury, I: smooth muscle growth in the absence of endothelium. Lab Invest. 1983;49:327-333.
    • (1983) Lab Invest , vol.49 , pp. 327-333
    • Clowes, A.W.1    Reidy, M.A.2    Clowes, M.M.3
  • 3
    • 0033987328 scopus 로고    scopus 로고
    • Transient reexpression of an embryonic autonomous growth phenotype by adult carotid artery SMC following vascular injury
    • Weiser-Evans MCM, Quinn BE, Burkard MR, Stenmark KR. Transient reexpression of an embryonic autonomous growth phenotype by adult carotid artery SMC following vascular injury. J Cell Physiol. 2000;182:12-23.
    • (2000) J Cell Physiol , vol.182 , pp. 12-23
    • Weiser-Evans, M.C.M.1    Quinn, B.E.2    Burkard, M.R.3    Stenmark, K.R.4
  • 4
    • 0026020827 scopus 로고
    • Role of basic fibroblast growth factor in vascular lesion formation
    • Lindner V, Lappi DA, Baird A, Majack RA, Reidy MA. Role of basic fibroblast growth factor in vascular lesion formation. Circ Res. 1991;68:106-113.
    • (1991) Circ Res , vol.68 , pp. 106-113
    • Lindner, V.1    Lappi, D.A.2    Baird, A.3    Majack, R.A.4    Reidy, M.A.5
  • 5
    • 0029136240 scopus 로고
    • Static tension is associated with increased smooth muscle cell DNA synthesis in rat pulmonary arteries
    • Weiser MCM, Majack RA, Tucker A, Orton EC. Static tension is associated with increased smooth muscle cell DNA synthesis in rat pulmonary arteries. Am J Physiol. 1995;268:H1133-H1138.
    • (1995) Am J Physiol , vol.268
    • Weiser, M.C.M.1    Majack, R.A.2    Tucker, A.3    Orton, E.C.4
  • 6
    • 0024456638 scopus 로고
    • The basement membrane of arterial smooth muscle cells
    • Heickendorff L. The basement membrane of arterial smooth muscle cells. APMIS. 1989(suppl)9:1-32.
    • (1989) APMIS , Issue.SUPPL. 9 , pp. 1-32
    • Heickendorff, L.1
  • 9
    • 0032615711 scopus 로고    scopus 로고
    • Relationship between perlecan and tropoelastin gene expression and cell replication in the developing rat pulmonary vasculature
    • Belknap JK, Weiser-Evans MCM, Grieshaber SS, Majack RA, Stenmark KR. Relationship between perlecan and tropoelastin gene expression and cell replication in the developing rat pulmonary vasculature. Respir Cell Mol Biol. 1999;20:24-34.
    • (1999) Respir Cell Mol Biol , vol.20 , pp. 24-34
    • Belknap, J.K.1    Weiser-Evans, M.C.M.2    Grieshaber, S.S.3    Majack, R.A.4    Stenmark, K.R.5
  • 12
    • 0028102255 scopus 로고
    • The biology of perlecan: The multifacted heparan sulfate proteoglycan of basement membranes and pericellular matrices
    • Iozzo RV, Cohen JR, Grassel S, Murdoch AD. The biology of perlecan: the multifacted heparan sulfate proteoglycan of basement membranes and pericellular matrices. Biochem J. 1994;302:625-639.
    • (1994) Biochem J , vol.302 , pp. 625-639
    • Iozzo, R.V.1    Cohen, J.R.2    Grassel, S.3    Murdoch, A.D.4
  • 16
    • 0037388983 scopus 로고    scopus 로고
    • Changes in perlecan expression during vascular injury: Role in the inhibition of smooth muscle cell proliferation in the late lesion
    • Kinsella MG, Tran PK, Weiser-Evans MC, Reidy M, Majack RA, Wight TN. Changes in perlecan expression during vascular injury: role in the inhibition of smooth muscle cell proliferation in the late lesion. Arterioscler Thromb Vasc Biol. 2003;23:608-614.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 608-614
    • Kinsella, M.G.1    Tran, P.K.2    Weiser-Evans, M.C.3    Reidy, M.4    Majack, R.A.5    Wight, T.N.6
  • 17
    • 0032431032 scopus 로고    scopus 로고
    • The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
    • Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci USA. 1998;95:15587-15591.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15587-15591
    • Wu, X.1    Senechal, K.2    Neshat, M.S.3    Whang, Y.E.4    Sawyers, C.L.5
  • 18
    • 0033575287 scopus 로고    scopus 로고
    • PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol-3-kinase/Akt cell survival pathway
    • Tamura M, Gu J, Damen EH, Takino T, Miyamoto S, Yamada KM. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol-3-kinase/Akt cell survival pathway. J Biol Chem. 1999;274:20693-20703.
    • (1999) J Biol Chem , vol.274 , pp. 20693-20703
    • Tamura, M.1    Gu, J.2    Damen, E.H.3    Takino, T.4    Miyamoto, S.5    Yamada, K.M.6
  • 19
    • 0033856110 scopus 로고    scopus 로고
    • PTEN, a unique tumor suppressor gene
    • Dahia PLM. PTEN, a unique tumor suppressor gene. Endocr Relat Cancer. 2000;7:115-129.
    • (2000) Endocr Relat Cancer , vol.7 , pp. 115-129
    • Dahia, P.L.M.1
  • 20
    • 0034921007 scopus 로고    scopus 로고
    • Tumor suppressor PTEN: Modulator of cell signaling, growth, migration and apoptosis
    • Yamada KM, Araki M. Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J Cell Sci. 2001;114:2375-2382.
    • (2001) J Cell Sci , vol.114 , pp. 2375-2382
    • Yamada, K.M.1    Araki, M.2
  • 21
    • 0031870959 scopus 로고    scopus 로고
    • PTEN is essential for embryonic development and tumor suppression
    • DiCristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP. PTEN is essential for embryonic development and tumor suppression. Nat Genet. 1998;19:348-355.
    • (1998) Nat Genet , vol.19 , pp. 348-355
    • DiCristofano, A.1    Pesce, B.2    Cordon-Cardo, C.3    Pandolfi, P.P.4
  • 23
    • 1642339843 scopus 로고    scopus 로고
    • A unique highly proliferative growth phenotype expressed by embryonic and neointimal SMC is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN
    • In press
    • Mourani PM, Garl PJ, Wenzlau JM, Carpenter TC, Stenmark KR, Weiser-Evans MCM. A unique highly proliferative growth phenotype expressed by embryonic and neointimal SMC is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN. Circulation. In press.
    • Circulation
    • Mourani, P.M.1    Garl, P.J.2    Wenzlau, J.M.3    Carpenter, T.C.4    Stenmark, K.R.5    Weiser-Evans, M.C.M.6
  • 24
    • 0036094861 scopus 로고    scopus 로고
    • Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN
    • Huang J, Kontos CD. Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN. Arterioscler Thromb Vasc Biol. 2002;22:745-751.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 745-751
    • Huang, J.1    Kontos, C.D.2
  • 25
    • 0033946740 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail regulates protein stability and function
    • Vazque F, Ramaswamy S, Nakamura N, Sellers WR. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol. 2000;20:5010-5018.
    • (2000) Mol Cell Biol , vol.20 , pp. 5010-5018
    • Vazque, F.1    Ramaswamy, S.2    Nakamura, N.3    Sellers, W.R.4
  • 26
    • 0035966127 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
    • Vazquez F, Grossman S, Takahashi Y, Rokas M, Nakamura N, Sellers WR. Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem. 2001;276:48627-48630.
    • (2001) J Biol Chem , vol.276 , pp. 48627-48630
    • Vazquez, F.1    Grossman, S.2    Takahashi, Y.3    Rokas, M.4    Nakamura, N.5    Sellers, W.R.6
  • 27
    • 0034462121 scopus 로고    scopus 로고
    • Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN
    • Nakamura N, Ramaswamy S, Vazquez F, Signoretti S, Loda M, Sellers WR. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol. 2000;20:8969-8982.
    • (2000) Mol Cell Biol , vol.20 , pp. 8969-8982
    • Nakamura, N.1    Ramaswamy, S.2    Vazquez, F.3    Signoretti, S.4    Loda, M.5    Sellers, W.R.6
  • 28
    • 0026418308 scopus 로고
    • Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF
    • Ferns GA, Raines EW, Sprugel KH, Motani AS, Reidy MA, Ross R. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science. 1991;253:1129-1132.
    • (1991) Science , vol.253 , pp. 1129-1132
    • Ferns, G.A.1    Raines, E.W.2    Sprugel, K.H.3    Motani, A.S.4    Reidy, M.A.5    Ross, R.6
  • 29
    • 0025817390 scopus 로고
    • Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor
    • Lindner V, Reidy MA. Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor. Proc Natl Acad Sci USA. 1991;88:3739-3743.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3739-3743
    • Lindner, V.1    Reidy, M.A.2
  • 30
    • 0028146228 scopus 로고
    • Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat
    • Bendeck MP, Zempo N, Clowes AW, Galardy RE, Reidy MA. Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat. Circ Res. 1994;75:539-545.
    • (1994) Circ Res , vol.75 , pp. 539-545
    • Bendeck, M.P.1    Zempo, N.2    Clowes, A.W.3    Galardy, R.E.4    Reidy, M.A.5
  • 31
    • 0029876376 scopus 로고    scopus 로고
    • The degradation of human endothelial cell-derived perlecan and release of bound fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases
    • Whitelock JM, Murdoch AD, Iozzo RV, Underwod PA. The degradation of human endothelial cell-derived perlecan and release of bound fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases. J Biol Chem. 1996;271:10079-10086.
    • (1996) J Biol Chem , vol.271 , pp. 10079-10086
    • Whitelock, J.M.1    Murdoch, A.D.2    Iozzo, R.V.3    Underwod, P.A.4
  • 32
    • 0033767872 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling is important for smooth muscle cell replication after arterial injury
    • Shigematsu K, Koyama H, Olson NE, Cho A, Reidy MA. Phosphatidylinositol 3-kinase signaling is important for smooth muscle cell replication after arterial injury. Arterioscler Thromb Vasc Biol. 2000;20:2373-2378.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 2373-2378
    • Shigematsu, K.1    Koyama, H.2    Olson, N.E.3    Cho, A.4    Reidy, M.A.5
  • 34
    • 0017576983 scopus 로고
    • Suppression by heparin of smooth muscle cell proliferation in injured arteries
    • Clowes AW, Kamovsky MJ. Suppression by heparin of smooth muscle cell proliferation in injured arteries. Nature. 1977;265:625-626.
    • (1977) Nature , vol.265 , pp. 625-626
    • Clowes, A.W.1    Kamovsky, M.J.2
  • 35
    • 0019829625 scopus 로고
    • Cultured endothelial cells produce a heparinlike inhibitor of smooth muscle cell growth
    • Castellot JJ, Addonizio ML, Rosenberg RD, Karnovsky MJ. Cultured endothelial cells produce a heparinlike inhibitor of smooth muscle cell growth. J Cell Biol. 1981;90:372-379.
    • (1981) J Cell Biol , vol.90 , pp. 372-379
    • Castellot, J.J.1    Addonizio, M.L.2    Rosenberg, R.D.3    Karnovsky, M.J.4
  • 36
    • 0021911622 scopus 로고
    • An antiproliferative heparan sulfate species produced by postconfluent smooth muscle cells
    • Fritze LM, Reilly CF, Rosenberg RD. An antiproliferative heparan sulfate species produced by postconfluent smooth muscle cells. J Cell Biol. 1985;100:1041-1049.
    • (1985) J Cell Biol , vol.100 , pp. 1041-1049
    • Fritze, L.M.1    Reilly, C.F.2    Rosenberg, R.D.3
  • 37
    • 0031849584 scopus 로고    scopus 로고
    • Arterial heparan sulfate proteoglycans inhibit vascular smooth muscle cell proliferation and phenotype change in vitro and neointimal formation in vivo
    • Bingley JA, Hayward IP, Campbell JH, Campbell GR. Arterial heparan sulfate proteoglycans inhibit vascular smooth muscle cell proliferation and phenotype change in vitro and neointimal formation in vivo. J Vasc Surg. 1998;28:308-318.
    • (1998) J Vasc Surg , vol.28 , pp. 308-318
    • Bingley, J.A.1    Hayward, I.P.2    Campbell, J.H.3    Campbell, G.R.4
  • 38
    • 0034612309 scopus 로고    scopus 로고
    • Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia
    • Nugent MA, Nugent HM, Iozzo RV, Sanchack K, Edelman ER. Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia. Proc Natl Acad Sci USA. 2000;97:6722-6727.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6722-6727
    • Nugent, M.A.1    Nugent, H.M.2    Iozzo, R.V.3    Sanchack, K.4    Edelman, E.R.5
  • 39
    • 0032893101 scopus 로고    scopus 로고
    • Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells
    • Whitelock JM, Graham LD, Melrose J, Murdoch AD, Iozzo RV, Underwood PA. Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells. Matrix Biol. 1999;18:163-178.
    • (1999) Matrix Biol , vol.18 , pp. 163-178
    • Whitelock, J.M.1    Graham, L.D.2    Melrose, J.3    Murdoch, A.D.4    Iozzo, R.V.5    Underwood, P.A.6
  • 41
    • 0031770342 scopus 로고    scopus 로고
    • The relationship between perlecan and dystroglycan and its implication in the formation of the neuromuscular junction
    • Peng HB, Ali AA, Daggett DF, Rauvala H, Hassell JR, Smalheiser NR. The relationship between perlecan and dystroglycan and its implication in the formation of the neuromuscular junction. Cell Adhes Commun. 1998;5:475-489.
    • (1998) Cell Adhes Commun , vol.5 , pp. 475-489
    • Peng, H.B.1    Ali, A.A.2    Daggett, D.F.3    Rauvala, H.4    Hassell, J.R.5    Smalheiser, N.R.6
  • 42
    • 0026463887 scopus 로고
    • Endothelial cells interact with the core protein of basement membrane perlecan through β1 and β3 integrins: An adhesion modulated by glycosaminoglycan
    • Hayashi K, Madri JA, Yurchenco PD. Endothelial cells interact with the core protein of basement membrane perlecan through β1 and β3 integrins: an adhesion modulated by glycosaminoglycan. J Cell Biol. 1992;119:945-959.
    • (1992) J Cell Biol , vol.119 , pp. 945-959
    • Hayashi, K.1    Madri, J.A.2    Yurchenco, P.D.3
  • 43
    • 0035137373 scopus 로고    scopus 로고
    • Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells
    • Taylor JM, Mack CP, Nolan K, Regan CP, Owens GK, Parsons JT. Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells. Mol Cell Biol. 2001;21:1565-1572.
    • (2001) Mol Cell Biol , vol.21 , pp. 1565-1572
    • Taylor, J.M.1    Mack, C.P.2    Nolan, K.3    Regan, C.P.4    Owens, G.K.5    Parsons, J.T.6
  • 44
    • 0034529045 scopus 로고    scopus 로고
    • Lipoprotein modulation of subendothelial heparan sulfate proteoglycans (perlecan) and atherogenicity
    • Pillarisetti S. Lipoprotein modulation of subendothelial heparan sulfate proteoglycans (perlecan) and atherogenicity. Trends Cardiovasc Med. 2000;10:60-65.
    • (2000) Trends Cardiovasc Med , vol.10 , pp. 60-65
    • Pillarisetti, S.1
  • 45
    • 0031054689 scopus 로고    scopus 로고
    • Structural and functional characterization of the human perlecan gene promoter: Transcriptional activation by transforming growth factor-β via a nuclear factor 1-binding element
    • Iozzo RV, Pillarisetti J, Sharma B, Murdoch AD, Danielson KG, Uitto J, Mauviel A. Structural and functional characterization of the human perlecan gene promoter: transcriptional activation by transforming growth factor-β via a nuclear factor 1-binding element. J Biol Chem. 1997;272:5219-5228.
    • (1997) J Biol Chem , vol.272 , pp. 5219-5228
    • Iozzo, R.V.1    Pillarisetti, J.2    Sharma, B.3    Murdoch, A.D.4    Danielson, K.G.5    Uitto, J.6    Mauviel, A.7


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