Synthesis, structures and anti-HBV activities of derivatives of the glutarimide antibiotic cycloheximide

Journal of Antibiotics

Volumn 62, Issue 11, 2009, Pages 639-642

  Guo, Hui Fang ^a   Li, Yu Huan ^a   Yi, Hong ^a   Zhang, Tian ^a   Wang, Shu Qin ^a   Tao, Pei Zhen ^a   Li, Zhuo Rong ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Anhydrocycloheximide; Antiviral activity; Crystal structure; Cycloheximide

Indexed keywords

CYCLOHEXIMIDE; GLUTARIMIDE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS B VIRUS; IC 50; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES GRISEUS;

ANTIVIRAL AGENTS; CYCLOHEXIMIDE; HEPATITIS B VIRUS; PIPERIDONES; X-RAY DIFFRACTION;

HEPATITIS B VIRUS;

EID: 72449185192     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2009.87     Document Type: Article

References (10)

1. Croons, V., Martinet, W., Herman, A. G. & De Meyer, G. R. Differential effect of the protein synthesis inhibitors puromycin and cycloheximide on vascular smooth muscle cell viability. J. Pharmacol. Exp. Ther. 325, 824-832 (2008).
2. Kit, S., Kurimura, T., De Torres, R. A. & Dubbs, D. R. Simian virus 40 deoxyribonucleic acid replication. I. Effect of cycloheximide on the replication of SV40 deoxyribonucleic acid in monkey kidney cells and in heterokaryons of SV40-transformed and susceptible cells. J. Virol. 3, 25-32 (1969).
3. Mark, G. E., Taylor, J. M., Broni, B. & Krug, R. M. Nuclear accumulation of influenza viral RNA transcripts and the effects of cycloheximide, actinomycin D, and alphaamanitin. J. Virol. 29, 744-752 (1979).
4. Watanabe, Y., Kudo, H. & Graham, A. F. Selective inhibition of reovirus ribonucleic acid synthesis by cycloheximide. J. Virol. 1, 36-44 (1967).
5. Friedman, R. M. & Grimley, P. M. Inhibition of arbovirus assembly by cycloheximide. J. Virol. 4, 292-299 (1969).
6. Crance, J. M., Biziagos, E., Passagot, J., van Cuyck-Gandré , H. & Deloince, R. Inhibition of hepatitis A virus replication in vitro by antiviral compounds. J. Med. Virol. 31, 155-160 (1990).
7. Irvine, J. H., Horsfield, J. A., McKinney, C. Z. & Tate, W. P. A novel strategy to interfere with human immunodeficiency virus type 1 propagation. N. Z. Med. J. 111, 222-224 (1998).
8. Choudhary,S.K.et al. CXCR4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immature infected thymocytes that resembles thymocyte negative selection. Virology 352, 268-284 (2006).
9. Schaeffer, H. J. & Jain, V. K. Investigation of the stereochemistry of cycloheximide. J. Pharm. Sci. 53, 144-147 (1964).
10. Gensler, W. J., Johnson, F. & David, A. Compounds related to podophyllotoxin. XII. podophyllone and dehydropodophyllotoxin. J. Am. Chem. Soc. 82, 6074-6081 (1960).