Removal of the Bloom syndrome DNA helicase extends the utility of imprecise transposon excision for making null mutations in Drosophila

Genetics

Volumn 183, Issue 3, 2009, Pages 1187-1193

  Witsell, Alice ^a   Kane, Daniel P ^a   Rubin, Sarah ^a   McVey, Mitch ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOM SYNDROME HELICASE; GENOMIC DNA;

DNA FLANKING REGION; DOUBLE STRANDED DNA BREAK; DROSOPHILA MELANOGASTER; EXCISION REPAIR; GENE DELETION; GENE MUTATION; MUTANT; NONHUMAN; NOTE; NULL ALLELE; ORTHOLOGY; PRIORITY JOURNAL; TRANSPOSON;

ANIMALS; DNA BREAKS, DOUBLE-STRANDED; DNA HELICASES; DNA REPAIR; DNA TRANSPOSABLE ELEMENTS; DROSOPHILA MELANOGASTER; FEMALE; FERTILITY; GENE DELETION; GENOME, INSECT; MALE; MUTAGENESIS, INSERTIONAL; MUTATION;

DROSOPHILA MELANOGASTER;

EID: 72449133298     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.109.108472     Document Type: Note

References (42)

1. Arca, B., S. Zabalou, T. G. Loukeris and C. Savakis, 1997 Mobilization of a Minos transposon in Drosophila melanogaster chromosomes and chromatid repair by heteroduplex formation. Genetics 145: 267-279. (Pubitemid 27068382)
2. Astrom, S. U., T. W. Cline and J. Rine, 2003 The Drosophila melanogaster sir21 gene is nonessential and has only minor effects on position-effect variegation. Genetics 163: 931-937.
3. Bachrati, C. Z., R. H. Borts and I. D. Hickson, 2006 Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase. Nucleic Acids Res. 34: 2269-2279.
4. Beall, E. L., and D. C. Rio, 1996 Drosophila IRBP/Ku p70 corresponds to the mutagen-sensitive mus309 gene and is involved in P-element excision in vivo. Genes Dev. 10: 921-933.
5. Beall, E. L., and D. C. Rio, 1997 Drosophila P-element transposase is a novel site-specific endonuclease. Genes Dev. 11: 2137-2151.
6. Bellen, H. J., R. W. Levis, G. Liao, Y. He, J. W. Carlson et al., 2004 The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics 167: 761-781.
7. Bibikova, M., M.Golic, K.G. Golic and D. Carroll, 2002 Targeted chromosomal cleavage and mutagenesis in Drosophila using zincfinger nucleases. Genetics 161: 1169-1175.
8. Bozas, A., K. J. Beumer, J. K. Trautman and D. Carroll, 2009 Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila. Genetics 182: 641-651.
9. Carroll, D., K. J. Beumer, J. J.Morton, A. Bozas and J. K. Trautman, 2008 Gene targeting in Drosophila and Caenorhabditis elegans with zinc-finger nucleases. Methods Mol. Biol. 435: 63-77.
10. Cooley, L., R. Kelley and A. Spradling, 1988 Insertional mutagenesis of the Drosophila genome with single P elements. Science 239: 1121-1128. (Pubitemid 18084318)
11. Doyon, Y., J. M. McCammon, J. C. Miller, F. Faraji, C. Ngo et al., 2008 Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nat. Biotechnol. 26: 702-708.
12. Engels, W. R., D. M. Johnson-Schlitz, W. B. Eggleston and J. Sved, 1990 High-frequency P element loss in Drosophila is homolog dependent. Cell 62: 515-525.
13. Franz, G., and C. Savakis, 1991 Minos, a new transposable element from Drosophila hydei, is a member of the Tc1-like family of transposons. Nucleic Acids Res. 19: 6646.
14. Garcia, A. M., A. Derventzi, R. Busuttil, R. B. Calder, E. Perez, Jr. et al., 2007 A model system for analyzing somatic mutations in Drosophila melanogaster. Nat. Methods 4: 401-403.
15. Hacker, U., S. Nystedt, M. P. Barmchi, C. Horn and E. A. Wimmer, 2003 piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila. Proc. Natl. Acad. Sci. USA 100: 7720-7725.
16. Horn, C., N. Offen, S. Nystedt, U. Hacker and E. A. Wimmer, 2003 piggyBac-based insertional mutagenesis and enhancer detection as a tool for functional insect genomics. Genetics 163: 647-661. (Pubitemid 36314547)
17. Hummel, T., and C. Klambt, 2008 P-element mutagenesis. Methods Mol. Biol. 420: 97-117.
18. Johansson, A. M., P. Stenberg, C. Bernhardsson and J. Larsson, 2007 Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster. EMBO J. 26: 2307-2316.
19. Kelley, M. R., S. Kidd, R. L. Berg and M. W. Young, 1987 Restriction of P-element insertions at the Notch locus of Drosophila melanogaster. Mol. Cell. Biol. 7: 1545-1548.
20. Kusano, K., D. M. Johnson-Schlitz and W. R. Engels, 2001 Sterility of Drosophila with mutations in the Bloom syndrome gene- complementation by Ku70. Science 291: 2600-2602. (Pubitemid 32249683)
21. Lloyd, A., C.L. Plaisier, D. Carroll andG. N. Drews, 2005 Targeted mutagenesis using zinc-finger nucleases in Arabidopsis. Proc. Natl. Acad. Sci. USA 102: 2232-2237.
22. Loukeris, T. G., B. Arca, I. Livadaras, G. Dialektaki and C. Savakis, 1995 Introduction of the transposable element Minos into the germ line of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 92: 9485-9489.
23. McVey, M., J. R. Larocque, M. D. Adams and J. J. Sekelsky, 2004a Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion. Proc. Natl. Acad. Sci. USA 101: 15694-15699.
24. McVey, M., D. Radut and J. J. Sekelsky, 2004b End-joining repair of double-strand breaks in Drosophila melanogaster is largely DNA ligase IV independent. Genetics 168: 2067-2076. (Pubitemid 40066344)
25. McVey, M., S. L. Andersen, Y. Broze and J. Sekelsky, 2007 Multiple functions of Drosophila BLM helicase in maintenance of genome stability. Genetics 176: 1979-1992. (Pubitemid 47360635)
26. Meng, X., M. B. Noyes, L. J. Zhu, N. D. Lawson and S. A. Wolfe, 2008 Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases. Nat. Biotechnol. 26: 695-701.
27. Metaxakis, A., S. Oehler, A. Klinakis and C. Savakis, 2005 Minos as a genetic and genomic tool in Drosophila melanogaster. Genetics 171: 571-581. (Pubitemid 43156447)
28. Mitra, R., J. Fain-Thornton and N. L. Craig, 2008 piggyBac can bypass DNA synthesis during cut and paste transposition. EMBO J. 27: 1097-1109.
29. Morton, J., M. W. Davis, E. M. Jorgensen and D. Carroll, 2006 Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells. Proc. Natl. Acad. Sci. USA 103: 16370-16375.
30. O'Hare, K., and G. M. Rubin, 1983 Structures of the P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genome. Cell 34: 25-35.
31. Parks, A. L., K. R. Cook, M. Belvin, N. A. Dompe, R. Fawcett et al., 2004 Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome. Nat. Genet. 36: 288-292.
32. Preston, C. R., and W. R. Engels, 1996 Flanking duplications and deletions associated with P-induced male recombination in Drosophila. Genetics 144: 1623-1638.
33. Preston, C. R., C. C. Flores and W. R. Engels, 2006 Differential usage of alternative pathways of double-strand break repair in Drosophila. Genetics 172: 1055-1068. (Pubitemid 43345438)
34. Robertson, H. M., C. R. Preston, R. W. Phillis, D. M. Johnson-Schlitz, W. K. Benz et al., 1988 A stable genomic source of P element transposase in Drosophila melanogaster. Genetics 118: 461-470.
35. Ryder, E., and S. Russell, 2003 Transposable elements as tools for genomics and genetics in Drosophila. Brief. Funct. Genomic Proteomic 2: 57-71.
36. Ryder, E., M. Ashburner, R. Bautista-Llacer, J. Drummond, J. Webster et al., 2007 The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource. Genetics 177: 615-629.
37. Smith, D., J. Wohlgemuth, B. R. Calvi, I. Franklin and W. M. Gelbart, 1993 hobo enhancer trapping mutagenesis inDrosophila reveals an insertion specificity different from P elements. Genetics 135: 1063-1076.
38. Spradling, A. C., D. Stern, A. Beaton, E. J. Rhem, T. Laverty et al., 1999 The Berkeley Drosophila Genome Project gene disruption project: single P-element insertions mutating 25% of vital Drosophila genes. Genetics 153: 135-177.
39. Thibault, S. T., M. A. Singer, W. Y. Miyazaki, B. Milash, N. A. Dompe et al., 2004 A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac. Nat. Genet. 36: 283-287.
40. Tsubota, S., M. Ashburner and P. Schedl, 1985 P-elementinduced control mutations at the r gene of Drosophila melanogaster. Mol. Cell. Biol. 5: 2567-2574.
41. Wei, D. S., and Y. S. Rong, 2007 A genetic screen for DNA doublestrand break repair mutations in Drosophila. Genetics 177: 63-77. (Pubitemid 47555831)
42. Weinert, B. T., and D. C. Rio, 2007 DNA strand displacement, strand annealing and strand swapping by the Drosophila Bloom's syndrome helicase. Nucleic Acids Res. 35: 1367-1376.