Knock-in of diphteria toxin a chain gene at Ins2 locus: Effects on islet development and localization of Ins2 expression in the brain

Transgenic Research

Volumn 13, Issue 5, 2004, Pages 463-473

  Lamotte, Luciane ^a   Jackerott, Malene ^b   Bucchini, Danielle ^a   Jami, Jacques ^a   Joshi, Rajiv ^a   Deltour, Louise ^a  

^a INSTITUT COCHIN   (France)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

choroid plexus; dta knock in; genetic ablation; insulin gene; pancreatic islets

Indexed keywords

DIPHTHERIA TOXIN; DIPHTHERIA TOXIN FRAGMENT A; INSULIN; PEPTIDE FRAGMENT;

ANIMAL; ARTICLE; CHOROID PLEXUS; DIABETIC KETOACIDOSIS; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; LACTOSE OPERON; METABOLISM; MOUSE; PANCREAS; PANCREAS ISLET; PATHOLOGY; PROMOTER REGION; TRANSGENIC MOUSE;

ANIMALS; CHOROID PLEXUS; DIABETIC KETOACIDOSIS; DIPHTHERIA TOXIN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC VECTORS; INSULIN; ISLETS OF LANGERHANS; LAC OPERON; MICE; MICE, TRANSGENIC; PANCREAS; PEPTIDE FRAGMENTS; PROMOTER REGIONS (GENETICS);

EID: 7244238181     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11248-004-9587-x     Document Type: Article

References (39)

1. Ahlgren U, Jonsson, J and Edlund H (1996) The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122: 1409-1416.
2. Deltour L, Jami J and Bucchini D (1992) Discrimination of homologous mRNAs by polymerase chain reaction. Meth Mol Cell Biol 3: 35-38.
3. Deltour L, Leduque P, Blume N, Madsen O, Dubois P, Jami J et al. (1993) Differential expression of the two non-allelic proinsulin genes in the developing mouse embryo. Proc Natl Acad Sci USA 90: 527-531.
4. Deltour L, Montagutelli X, Guenet JL, Jami J and Paldi A (1995) Tissue- and developmental stage-specific imprinting of the mouse proinsulin gene, Ins2. Dev Biol 168: 686-688.
5. Diaz B, Serna J, De Pablo F and de la Rosa EJ (2000) In vivo regulation of cell death by embryonic (pro)insulin and the insulin receptor during early retinal neurogenesis. Development 127: 1641-1649.
6. Duvillié B, Cordonnier N, Deltour L, Dandoy-Dron F, Itier J-M, Monthioux E et al. (1997) Phenotypic alterations in insulin-deficient mutant mice. Proc Natl Acad Sci USA 94: 5137-5140.
7. Ferber S, Halkin A, Cohen H, Ber I, Einav Y, Goldberg I et al. (2000) Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 6: 568-572.
8. Giddings SJ, King CD, Harman KW, Flood JF and Carnaghi LR (1994) Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting. Nature Genet 6: 310-313.
9. Hernandez-Sanchez C, Rubio E, Serna J, de la Rosa EJ and de Pablo F (2002) Unprocessed proinsulin promotes cell survival during neurulation in the chick embryo. Diabetes 51: 770-777.
10. Herrera P-L, Huarte J, Sanvito F, Meda P, Orci L and Vassalli JD (1991) Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development 113: 1257-1265.
11. Herrera P-L, Huarte J, Zufferey R, Nichols A, Mermillod B et al. (1994) Ablation of islet endocrine cells by targeted expression of hormone-promoter- driven toxigenes. Proc Natl Acad Sci USA 91: 12999-13003.
12. Herrera P-L (2000) Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 127: 2317-2322.
13. Jackerott M, Baudry A, Lamothe B, Bucchini D, Jami J et al. (2001) Endocrine pancreas in insulin receptor-deficient mouse pups. Diabetes 50 (Suppl 1): S146-149.
14. Jonsson J, Carlsson L, Edlund T and Edlund H (1994) Insulin-promoter- factor 1 is required for pancreas development in mice. Nature 371: 606-609.
15. Kromer-Metzger E and Lagueux M (1994) Expression of the gene encoding an insulin-related peptide in Locusta (Insecta, Orthoptera). Evidence for alternative promoter usage. Eur J Biochem 221: 427-434.
16. Kritzik MR, Jones E, Chen Z, Krakowski M, Krahl T, Good A et al. (1999) PDX-1 and Msx-2 expression in the regenerating and developing pancreas. J Endocrinol 163: 523-530.
17. Le Mouellic H, Lallemand Y and Brulet P (1990) Targeted replacement of the homeobox gene Hox-31 by the Escherichia coli lacZ in mouse chimeric embryos. Proc Natl Acad Sci USA 87: 4712-4716.
18. Leroux L, Desbois P, Lamotte L, Duvillié B, Cordonnier N, Jackerott M et al. (2001) Compensatory responses in mice carrying a null mutation for Ins1 or Ins2. Diabetes 50 (Suppl 1): S150-153.
19. Linde S, Nielsen JH, Hansen B and Welinder BS (1989) Reversed-phase high-performance liquid chromatographic analyses of insulin biosynthesis in isolated rat and mouse islets. J. Chromatogr. 462: 243-254.
20. Moore GE, Abu-Amero SN, Wading EL, Kingsnorth A, Stanier P, Jauniaux E et al. (2001) Evidence that insulin is imprinted in the human yolk sac. Diabetes 50: 199-203.
21. Nakamura T, Kishi A, Nishio Y, Maegawa H, Egawa K, Wong NC et al. (2001) Insulin production in a neuroectodermal tumor that expresses islet factor-1, but not pancreatic-duodenal homeobox 1. J Clin Endocrinol Metab 86: 1795-1800.
22. Perez-Villamil B, Schwartz PT and Vallejo M (1999) The pancreatic homeodomain transcription factor IDX1/IPF1 is expressed in neural cells during brain development. Endocrinology 140: 3857-3860.
23. Pimentel B, de la Rosa EJ and de Pablo F (1996) Insulin acts as an embryonic growth factor for Drosophila neural cells. Biochem Biophys Res Commun 226: 855-861.
24. Pugliese A, Zeller M, Fernandez A Jr, Zalcberg LJ, Bartlett RJ, Ricordi C et al. (1997) The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 15: 293-297.
25. Rulifson EJ, Kim SK and Nusse R. (2002) Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296: 1118-1120.
26. Sharma A, Zangen DH, Reitz P, Taneja M, Lissauer ME, Miller CP et al. (1999) The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 48: 507-513.
27. Schechter R, Holtzclaw L, Sadiq F, Kahn A and Devaskar S (1988) Insulin synthesis by isolated rabbit neurons. Endocrinology 123: 505-513.
28. Schechter R, Whitmire J, Holtzclaw L, George M, Harlow R and Devaskar SU (1992) Developmental regulation of insulin in the mammalian central nervous system. Brain Res 582: 27-37.
29. Schechter R, Whitmire J, Wheet GS, Beju D, Jackson KW, Harlow R et al. (1994) Immunohistochemical and in situ hybridization study of an insulin-like substance in fetal neuron cell cultures. Brain Res 636: 9-27.
30. Schechter R, Beju D, Gaffney T, Schaefer F and Whetsell L (1996) Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system. Brain Res 736: 16-27.
31. Schechter R, Yanovitch T, Abboud M. Johnson G 3rd and Gaskins J (1998) Effects of brain endogenous insulin on neurofilament and MAPK in fetal rat neuron cell cultures. Brain Res 808: 270-278.
32. Schechter R, Abboud M and Johnson G (1999) Brain endogenous insulin effects on neurite growth within fetal rat neuron cell cultures. Brain Res Der Brain Res 116: 159-167.
33. Schwartz PT, Perez-Villamil B, Rivera A, Moratalla R, and Vallejo M. (2000) Pancreatic homeodomain transcription factor IDX1/IPF1 expressed in developing brain regulates somatostatin gene transcription in embryonic neural cells. J Biol Chem. 275: 19106-19114.
34. Smit AB, Vreugdenhil E, Ebberink RH, Geraerts WP, Klootwijk J and Joosse J (1988) Growth-controlling molluscan neurons produce the precursor of an insulin-related peptide. Nature 331: 535-538.
35. Sosa-Pineda B, Chowdhury K, Torres M, Oliver G and Gruss P (1997) The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature 386: 399-402.
36. Teitelman G, Alpert S, Polak JM, Martinez A and Hanahan D (1993) Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118: 1031-1039.
37. Wilson ME, Scheel D and German MS (2003) Gene expression cascades in pancreatic development. Mech Dev 120: 65-80.
38. Wolkow CA, Kimura KD, Lee MS and Ruvkun G (2000) Regulation of C elegans life-span by insulin-like signaling in the nervous system. Science 290: 147-150.
39. Young SW (1986) Periventricular hypothalamic cells in the rat brain contain insulin mRNA Neuropeptides 8: 93-97.