Maternal-fetal transfer and amniotic fluid accumulation of nucleoside analogue reverse transcriptase inhibitors in human immunodeficiency virus-infected pregnant women

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 11, 2004, Pages 4332-4336

  Chappuy, Hélène ^a   Tréluyer, Jean Marc ^a,b   Jullien, Vincent ^a   Dimet, Jérôme ^a   Rey, Elisabeth ^a   Fouché, Maria ^b   Firtion, Ghislaine ^b   Pons, Gérard ^a   Mandelbrot, Laurent ^c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b Hôpital Necker Enfants Malades ^*  (France)

^c HÔPITAL LOUIS MOURIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; DRUG METABOLITE; LAMIVUDINE; NUCLEOSIDE ANALOG; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; ZIDOVUDINE; ZIDOVUDINE GLUCURONIDE;

ADULT; AMNION FLUID; ARTICLE; CESAREAN SECTION; DELIVERY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DIFFUSION; DRUG EFFICACY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MATERNAL BLOOD; PLACENTAL TRANSFER; PREGNANT WOMAN; PRIORITY JOURNAL; UMBILICAL CORD BLOOD; URINARY EXCRETION; VEIN PUNCTURE;

ADULT; AMNIOTIC FLUID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; FETAL BLOOD; HIV INFECTIONS; HUMANS; MATERNAL-FETAL EXCHANGE; PREGNANCY; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 7244234280     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.11.4332-4336.2004     Document Type: Article

References (26)

1. Bawdon, R. E. 1998. The ex vivo human placental transfer of the anti-HIV nucleoside inhibitor abacavir and the protease inhibitor amprenavir. Infect. Dis. Obstet. Gynecol. 6:244-246.
2. Blanche, S., M. Tardieu, P. Rustin, A. Slama, B. Barret, G. Firtion, N. Ciraru-Vigneron, C. Lacroix, C. Rouzioux, L. Mandelbrot, I. Desguerre, A. Rotig, M. J. Mayaux, and J. F. Delfraissy. 1999. Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues. Lancet 354:1084-1089.
3. Casey, B. M., and R. E. Bawdon. 1998. Placental transfer of ritonavir with zidovudine in the ex vivo placental perfusion model. Am. J. Obstet. Gynecol. 179:758-761.
4. Cooper, E. R., M. Charurat, L. Mofenson, I. C. Hansson, J. Pitt, C. Diaz, and K. Hayani. 2002. Combination antiretroviral strategies for the treatment of pregnant HIV-1 infected women and prevention of perinatal HIV-1 transmission. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 29:484-494.
5. Culnane, M., M. G. Fowler, S. S. Lee, G. McSherry, M. Brady, K. O'Donnell, L. Mofenson, S. L. Gortmaker, D. E. Shapiron, G. Scott, E. Jimenez, E. C. Moore, C. Diaz, P. M. Flynn, B. Cunningham, and J. Oleske. 1999. Lack of longterm effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women. JAMA 281:151-157.
6. Dancis, J., J. D. Lee, S. Mendoza, and L. Liebes. 1993. Transfer and metabolism of dideoxyinosine by the perfused human placenta. J. Acquir. Immune Defic. Syndr. 6:2-6.
7. Dorenbaum, A., C. K. Cunningham, R. D. Gelber, M. Culnane, L. Mofenson, P. Britto, C. Rekacewicz, M. L. Newell, J. F. Delfraissy, B. Cunningham-Schrader, M. Mirochnick, J. L. Sullivan, et al. 2002. Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trial. JAMA 288:189-198.
8. Hanson, I. C., T. A. Antonelli, R. S. Sperling, J. M. Oleske, E. Cooper, M. Culnane, L. A. Fowler Kalish, S. S. Lee, G. McSherry, L. Mofenson, and D. E. Shapiro. 1999. Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 20:463-467.
9. Henderson, G. I., A. B. Perez, Y. Yang, R. L. Hamby, R. S. Schenken, and S. Schenker. 1994. Transfer of dideoxyinosine across the human isolated placenta. Br. J. Clin. Pharmacol. 38:237-242.
10. Kourtis, A. P., M. Bulterys, S. R. Nesheim, and F. K. Lee. 2001. Understanding the timing of HIV transmission from mother-to-infant. JAMA 285:709-712.
11. Mandelbrot, L., M. Burgard, J. P. Teglas, J. L. Bénifla, C. Kahn, P. Blot, E. Vilmer, S. Math, G. Firtion, S. Blanche, M. J. Mayaux, and C. Rouzioux. 1999. Frequent detection of HIV-1 in the gastric aspirates of neonates born to HIV-infected mothers. AIDS 13:2143-2149.
12. Mandelbrot, L., G. Peytavin, G. Firtion, and R. Farinotti. 2001. Maternal-fetal transfer and amniotic fluid accumulation of lamivudine in HIV infected pregnant women. Am. J. Obstet. Gynecol. 184:153-158.
13. Minkoff, H., and M. Augenbraun. 1997. Antiretroviral therapy for pregnant women. Am. J. Obstet. Gynecol. 176:478-489.
14. Moodley, J., D. Moodley, K. Pillay, H. Coovadia, J. Saba, R. van Leeuwen, C. Goodwin, P. R. Harrigan, K. H. Moore, C. Stone, R. Plumb, and M. A. Johnson. 1998. Pharmacokinetics and antiretroviral activity of lamivudine alone or when coadministered with zidovudine in human immunodeficiency virus type 1-infected pregnant women and their offspring. J. Infect. Dis. 178:1327-1333.
15. O'Sullivan, M. J., P. J. Boyer, G. B. Scott, W. P. Parks, S. Weller, M. R. Blum, J. Balsley, Y. J. Bryson, et al. 1993. The pharmacokinetics and safety of zidovudine in the third trimester of pregnancy for women infected with human immunodeficiency virus and their infants: phase I acquired immunodeficiency syndrome clinical trials group study (protocol 082). Am. J. Obstet. Gynecol. 168:1510-1516.
16. Patterson, T. A., Z. K. Binienda, G. W. Lipe, M. P. Gillam, W. Slikker, Jr., and J. A. Sandberg. 1997. Transplacental pharmacokinetics and fetal distribution of azidothymidine, its glucuronide, and phosphorylated metabolites in late-term rhesus macaques after maternal infusion. Drug Metab. Dispos. 25:453-459.
17. Pereira, C. M., C. Nosbisch, H. R. Winter, W. L. Baughman, and J. D. Unadkat. 1994. Transplacental pharmacokinetics of dideoxyinosine in pig-tailed macaques. Antimicrob. Agents Chemother. 38:781-786.
18. Pons, J. C., A. M. Taburet, E. Singlas, J. F. Delfraissy, and E. Papiernik. 1991. Placental passage of zidovudine during the second trimester of pregnancy: study by direct foetal blood sampling under ultrasound. Eur. J. Gynecol. Obstet. Biol. Reprod. 40:229-231.
19. Public Health Service Task Force. 2002. Recommendations for use of antiretroviral drugs in pregnant HIV-1 infected women. Safety and toxicity of individual andretroviral agents in pregnancy. May 23, 2002. http://www .AIDSinfo.nih.gov.
20. Public Health Service Task Force. 2003. Recommendations for use of antiretroviral drugs in pregnant HIV-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States. June 16, 2003. http://AIDSinfo.nih.gov.
21. Rodman, J. H., P. Flynn, B. Robbins, E. Jimenez, A. D. Bardeguez, J. F. Rodriguez, S. Blanchard, and A. Fridland. 1999. Systemic pharmacokinetics and cellular pharmacology of zidovudine in HIV-1 infected women and newborn infants. J. Infect. Dis. 180:1844-1850.
22. Sperling, R., D. Shapiro, R. W. Coombs, J. A. Todd, S. A. Herman, G. D. McSherry, M. J. O'Sullivan, R. B. Van Dyke, E. Jimenez, C. Rouzioux, P. M. Flynn, and J. L. Sullivan. 1996. Maternal vital load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. N. Engl. J. Med. 335:1621-1629.
23. Tuntland, T., A. Odinees, C. Nosbisch, and J. D. Unadkat. 1998. In vivo maternal-fetal-amniotic fluid pharmacokinetics of zidovudine in the pig-tailed macaque: comparison of steady-state and single-dose regimens. J. Pharmacol. Exp. Ther. 285:54-62.
24. Tuomala, R. E., D. Shapiro, L. M. Mofenson, Y. Bryson, M. Culnane, M. D. Hugues, M. J. Sullivan, G. Scott, A. M. Stek, D. Wara, and M. Bulterys. 2002. Antiretroviral therapy during pregnancy and the risk of an adverse outcome. N. Engl. J. Med. 346:1863-1870.
25. Wang, Y., E. Livingston, S. Patil, R. E. McKinney, A. D. Bardeguez, J. Gandia, P. Clax O'Sullivan, S. Huang, and J. D. Unadkat. 1999. Pharmacokinetics of didanosine in antepartum and postpartum human immunodeficiency virus-infected pregnant women and their neonates: an AIDS Clinical Trials Group study. J. Infect. Dis. 180:1536-1541.
26. Watts, D. H., Z. A. Brown, T. Tartaglione, S. K. Burchett, K. Opheim, R. Coombs, and L. Corey. 1991. Pharmacokinetic disposition of Zidovudine during pregnancy. J. Infect. Dis. 163:226-232.