Nonthermal GSM microwaves affect chromatin conformation in human lymphocytes similar to heat shock

IEEE Transactions on Plasma Science

Volumn 32, Issue 4 II, 2004, Pages 1600-1608

  Sarimov, Ruslan ^a,b   Malmgren, Lars O G ^c   Markovà, Eva ^a,d   Persson, Bertil R R ^e   Belyaev, Igor Y ^a,b  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b NATIONAL RESEARCH NUCLEAR UNIVERSITY MEPHI   (Russian Federation)

^c LUND UNIVERSITY   (Sweden)

^d CANCER RESEARCH INSTITUTE   (Slovakia)

^e LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL RADIATION EFFECTS; CELLS; CORRELATION METHODS; ELECTROMAGNETIC WAVE TRANSMISSION; GENETIC ENGINEERING; GLOBAL SYSTEM FOR MOBILE COMMUNICATIONS; HEAT TREATMENT;

BIOLOGICAL CELLS; BIOLOGICAL EFFECTS-OF-ELECTROMAGNETIC RADIATION; GENETICS; MOBILE PHONES;

MICROWAVES;

EID: 7244219779     PISSN: 00933813     EISSN: None     Source Type: Journal    
DOI: 10.1109/TPS.2004.832613     Document Type: Article

References (28)

1. L. Hardell, K. H. Mild, and M. Carlberg, "Further aspects on cellular and cordless telephones and brain tumours," Int. J. Oncol., vol. 22. pp. 399-407, 2003.
2. L. Hardell, K. H. Mild, A. Pahlson, and A. Hallquist, "Ionizing radiation, cellular telephones and the risk for brain tumours," Eur. J. Cancer Prev., vol. 10. pp. 523-529, 2001.
3. B. R. R. Persson, L. G. Salford, and A. Brun, "Blood-Brain Barrier permeability in rats exposed to electromagnetic fields used in wireless communication," Wireless Networks, vol. 3, pp. 455-461, 1997.
4. D. de Pomerai, C. Daniells, H. David, J. Allan, I. Duce, M. Mutwakil, D. Thomas, P. Sewell, J. Tattersall, D. Jones, and P. Candido, " Non-thermal heat-shock response to microwaves," Nature, vol. 405, pp. 417-418. 2000.
5. L. G. Salford, A. E. Brun, J. L. Eberhardt, L. Malmgren. and B. R. R. Persson. (2003) Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones. Environ. Health Pers. [Online], pp. 881-883. Available: http:/ /ehpnet1.niehs.nih.gov/docs/2003/6039/abstract.html
6. D. Leszczynski, S. Joenvaara, J. Reivinen, and R. Kuokka, " Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: Molecular mechanism for cancer-and blood-brain barrier-related effects," Differentiation, vol. 70. pp. 120-129, 2002.
7. M. L. Meltz, "Radiofrequency exposure and mammalian cell toxicity, genotoxicity, and transformation," Bioelectromagn., vol. 24, no. Suppl. 6, pp. S196-S213, 2003.
8. W. R. Adey, "Cell and molecular biology associated with radiation fields of mobile telephones," in Rev. Radio Sci. 1996-1999, W. R. Stone and S. Ueno, Eds. London, U.K.: Oxford, 1999, pp. 845-872.
9. I. Y. Belyaev, V. S. Shcheglov, E. D. Alipov, and V. D. Ushakov, " Non-thermal effects of extremely high frequency microwaves on chromatin conformation in cells in vitro: Dependence on physical, physiological and genetic factors," IEEE Trans. Microwave Theory Tech., vol. 48, pp. 2172-2179, Nov. 2000.
10. V. N. Binhi, Magnetobiology: Underlying Physical Problems. San Diego, CA: Academic, 2002.
11. C. F. Blackman, L. S. Kinney, D. E. House, and W. T. Joines, " Multiple power-density windows and their possible origin," Bioelectromagn., vol. 10, pp. 115-128, 1989.
12. A. G. Pakhomov, Y. Akyel, O. N. Pakhomova, B. E. Stuck, and M. R. Murphy, "Current state and implications of research on biological effects of millimeter waves: A review of the literature," Bioelectromagn., vol. 19, pp. 393-413, 1998.
13. I. Y. Belyaev, Y. D. Alipov, and V. S. Shcheglov, "Chromosome DNA as a target of resonant interaction between Escherichia coli cells and low-intensity millimeter waves," Electro-, Magnetobiol., vol. 11, pp. 97-108, 1992.
14. H. Lai and N. P Singh, "Melatonin and a spin-trap compound block radiofrequency electromagnetic radiation-induced DNA strand breaks in rat brain cells," Bioelectromagn., vol. 18, pp. 446-454, 1997.
15. I. Y. Belyaev, S. Eriksson, J. Nygren, J. Torudd, and M. Harms-Ringdahl, "Effects of ethidium bromide on DNA loop organization in human lymphocytes measured by anomalous viscosity time dependence and single cell gel electrophoresis," Biochim Biophys. Acta, vol. 1428, pp. 348-356, 1999.
16. I. Y. Belyaev, L. Hillert, C. Tamm, M. Harms-Ringdahl, L. Malmgren, and B. Persson. Effects of ELF and microwaves on human lymphocytes from hypersensitive persons. presented at Proc. 24th Bioelectromagn. Soc. Annu. Meeting. [Online]. Available: http:/ /www.bioelectromagnetics.org/doc/bems2002-abstracts.pdf.
17. I. Y. Belyaev, Y. D. Alipov, V. S. Shcheglov, and V. N. Lystsov, " Resonance effect of microwaves on the genome conformational state of E. coli cells," Z Naturforsch [C], vol. 47, pp. 621-627, 1992.
18. E. S. Ismailov, Biophysical Action of Microwaves. Moscow, U.S.S.R: Energoatomizdat, 1987.
19. D. I. de Pomerai, B. Smith, A. Dawe, K. North, T. Smith, D. B. Archer, I. R. Duce, D. Jones, and E. P. Candido, "Microwave radiation can alter protein conformation without bulk heating," Fed. Euro. Biochem. Soc. Lett., vol. 543, pp. 93-97, 2003.
20. I. Y. Belyaev and B. R. R. Persson, "Response of cells to electromagnetic fields of extremely low frequency and microwaves," in Int. Symp. Endogeneous Physical Fields Biol., Prague, Czech Republic, 2002. Presented.
21. P. S. Kingma and N. Osheroff, "The response of eukaryotic topoisomerases to DNA damage," Biochimica et Biophysica Acta, vol. 1400, pp. 223-232, 1998.
22. K. Dill and R. H. Shafer, "Radial migration of DNA molecules in cylindrical flow. III. Circles and the effect of non-Gaussian polymer statistics," Biophys. Chem., vol. 4. pp. 51-54, 1976.
23. V. S. Kriuchkov, V. A. Popunin, E. A. Alipov, and I. Beliaev, " Physical model of the anomalous time dependence effect of viscosity in high molecular weight DNA-protein complex solutions (in Russian)," Biofizika, vol. 40, pp. 1202-1207, 1995.
24. V. L. Ushakov, D. Bartenev, M. A. Borisiuk, I. Beliaev, E. D. Alipov, and V. S. Shcheglov, "Method of the anomalous time dependence of viscosity for registration of changes in conformational state of Escherichia coli cell genome (in Russian)," Biofizika, vol. 46, pp. 265-270, 2001.
25. I. Y. Belyaev, S. Czene, and M. Harms-Ringdahl, "Changes in chromatin conformation during radiation-induced apoptosis in human lymphocytes," Radiat. Res., vol. 156, pp. 355-364, 2001.
26. W. J. Rea, Y. Pan, E. J. Fenyves, I. Sujisawa, N. Samadi, and G. H. Ross, "Electromagnetic field sensitivity," J. Bioelectricity, vol. 10, pp. 241-256, 1991.
27. D. Plehn-Dujowich, P. Bell, A. M. Ishov, C. Baumann, and G. G. Maul, "Non-apoptotic chromosome condensation induced by stress: Delineation of interchromosomal spaces," Chromosoma, vol. 109. pp. 266-279, 2000.
28. R. Sarimov, J. Torudd, L. Hillert, L. Malmgren, B. Persson, M. Harms-Ringdahl, and I. Belyaev. GSM microwaves induce stress response in human lymphocytes. presented at 6th Int. Congr. Euro. BioElectromagn. Assoc. (EBEA). [Online]. Available: http://www.ebea.org/menu.html