Role of the AMPKγ3 isoform in hypoxia-stimulated glucose transport in glycolytic skeletal muscle

American Journal of Physiology - Endocrinology and Metabolism

Volumn 297, Issue 6, 2009, Pages

  Deshmukh, Atul S ^a   Glund, Stephan ^a   Tom, Robby Z ^a   Zierath, Juleen R ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Adenosine 5 monophosphate activated protein kinase; Calcium; Glucose metabolism; Signal transduction

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENOSINE PHOSPHATE ACTIVATED PROTEIN KINASE GAMMA 3; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; UNCLASSIFIED DRUG; BENZYLAMINE DERIVATIVE; CALCIUM; GLUCOSE; GLUCOSE TRANSPORTER; NUCLEAR PROTEIN; PRKAG3 PROTEIN, MOUSE; PROTEIN KINASE INHIBITOR; SULFONAMIDE; TBC1D1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CHANNEL GATING; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; EXTENSOR DIGITORUM LONGUS MUSCLE; FAST MUSCLE; FEMALE; GENE SILENCING; GLUCOSE TRANSPORT; GLYCOLYSIS; HYPOXIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SOLEUS MUSCLE; TRANSPORT KINETICS; WILD TYPE; ANIMAL; C57BL MOUSE; CELL HYPOXIA; ENZYMOLOGY; FAST MUSCLE FIBER; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY; SKELETAL MUSCLE; TRANSPORT AT THE CELLULAR LEVEL;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BENZYLAMINES; BIOLOGICAL TRANSPORT; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL HYPOXIA; FEMALE; GLUCOSE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE FIBERS, FAST-TWITCH; MUSCLE, SKELETAL; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 72249119041     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00125.2009     Document Type: Article

References (32)

1. Azevedo JL Jr, Carey JO, Pories WJ, Morris PG, Dohm GL. Hypoxia stimulates glucose transport in insulin-resistant human skeletal muscle. Diabetes 44: 695-698, 1995.
2. Barnes BR, Marklund S, Steiler TL, Walter M, Hjalm G, Amarger V, Mahlapuu M, Leng Y, Johansson C, Galuska D, Lindgren K, Abrink M, Stapleton D, Zierath JR, Andersson L. The 5′-AMP-activated protein kinase gamma 3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. J Biol Chem 279: 38441-38447, 2004. (Pubitemid 39295995)
3. Birk JB, Wojtaszewski JF. Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle. J Physiol 577: 1021-1032, 2006. (Pubitemid 44873663)
4. Cartee GD, Briggs-Tung C, Holloszy JO. Diverse effects of calcium channel blockers on skeletal muscle glucose transport. Am J Physiol Regul Integr Comp Physiol 263: R70-R75, 1992.
5. Cartee GD, Douen AG, Ramlal T, Klip A, Holloszy JO. Stimulation of glucose transport in skeletal muscle by hypoxia. J Appl Physiol 70: 1593-1600, 1991.
6. Chavez JA, Roach WG, Keller SR, Lane WS, Lienhard GE. Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem 283: 9187-9195, 2008.
7. Hansen PA, Gulve EA, Holloszy JO. Suitability of 2-deoxyglucose for in vitro measurement of glucose transport activity in skeletal muscle. J Appl Physiol 76: 979-985, 1994.
8. Hawley JA, Zierath JR. Integration of metabolic and mitogenic signal transduction in skeletal muscle. Exerc Sport Sci Rev 32: 4-8, 2004. (Pubitemid 38082438)
9. Holloszy JO. A forty-year memoir of research on the regulation of glucose transport into muscle. Am J Physiol Endocrinol Metab 284: E453-E467, 2003.
10. Jensen TE, Rose AJ, Jørgensen SB, Brandt N, Schjerling P, Wojtaszewski JF, Richter EA. Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction. Am J Physiol Endocrinol Metab 292: E1308-E1317, 2007. (Pubitemid 46684599)
11. Jørgensen SB, Viollet B, Andreelli F, Frøsig C, Birk JB, Schjerling P, Vaulont S, Richter EA, Wojtaszewski JF. Knockout of the alpha2 but not alpha1 5′-AMP-activated protein kinase isoform abolishes 5-aminoimidazole- 4-carboxamide-1-beta-4-ribofuranoside but not contraction-induced glucose uptake in skeletal muscle. J Biol Chem 279: 1070-1079, 2004. (Pubitemid 38082628)
12. Kane S, Lienhard GE. Calmodulin binds to the Rab GTPase activating protein required for insulin-stimulated GLUT4 translocation. Biochem Biophys Res Commun 335: 175-180, 2005. (Pubitemid 41350777)
13. Kennedy JW, Hirshman MF, Gervino EV, Ocel JV, Forse RA, Hoenig SJ, Aronson D, Goodyear LJ, Horton ES. Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes. Diabetes 48: 1192-1197, 1999. (Pubitemid 29226370)
14. Koistinen HA, Galuska D, Chibalin AV, Yang J, Zierath JR, Holman GD, Wallberg-Henriksson H. 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes 52: 1066-1072, 2003. (Pubitemid 36523338)
15. Kramer HF, Taylor EB, Witczak CA, Fujii N, Hirshman MF, Goodyear LJ. Calmodulin-binding domain of AS160 regulates contraction- but not insulin-stimulated glucose uptake in skeletal muscle. Diabetes 56: 2854-2862, 2007. (Pubitemid 350223618)
16. Kramer HF, Witczak CA, Taylor EB, Fujii N, Hirshman MF, Goodyear LJ. AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle. J Biol Chem 281: 31478-31485, 2006. (Pubitemid 46041412)
17. Krook A, Björnholm M, Galuska D, Jiang XJ, Fahlman R, Myers MG Jr, Wallberg-Henriksson H, Zierath JR. Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients. Diabetes 49: 284-292, 2000. (Pubitemid 30071007)
18. Long YC, Zierath JR. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116: 1776-1783, 2006. (Pubitemid 44033297)
19. Mahlapuu M, Johansson C, Lindgren K, Hjälm G, Barnes BR, Krook A, Zierath JR, Andersson L, Marklund S. Expression profiling of the γ-subunit isoforms of AMP-activated protein kinase suggests a major role for γ3 in white skeletal muscle. Am J Physiol Endocrinol Metab 286: E194-E200, 2004. (Pubitemid 38140309)
20. Mu J, Brozinick JT Jr, Valladares O, Bucan M, Birnbaum MJ. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell 7: 1085-1094, 2001. (Pubitemid 32525754)
21. Rezazadeh S, Claydon TW, Fedida D. KN-93 {2-[N-(2-hydroxyethyl)]- N-(4-methoxybenzenesulfonyl)amino-N-(4-chlorocinnamyl)- N-methylbenzylamine}, a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels. J Pharmacol Exp Ther 317: 292-299, 2006.
22. Roach WG, Chavez JA, Miinea CP, Lienhard GE. Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1. Biochem J 403: 353-358, 2007.
23. Ryder JW, Yang J, Galuska D, Rincón J, Björnholm M, Krook A, Lund S, Pedersen O, Wallberg-Henriksson H, Zierath JR, Holman GD. Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients. Diabetes 49: 647-654, 2000. (Pubitemid 30183755)
24. Sano H, Kane S, Sano E, Miinea CP, Asara JM, Lane WS, Garner CW, Lienhard GE. Insulin-stimulated phosphorylation of a Rab GTPaseactivating protein regulates GLUT4 translocation. J Biol Chem 278: 14599-14602, 2003. (Pubitemid 36799780)
25. Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7: 85-96, 2006. (Pubitemid 43278292)
26. Taylor EB, An D, Kramer HF, Yu H, Fujii NL, Roeckl KS, Bowles N, Hirshman MF, Xie J, Feener EP, Goodyear LJ. Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle. J Biol Chem 283: 9787-9796, 2008.
27. Thorell A, Hirshman MF, Nygren J, Jorfeldt L, Wojtaszewski JF, Dufresne SD, Horton ES, Ljungqvist O, Goodyear LJ. Exercise and insulin cause GLUT-4 translocation in human skeletal muscle. Am J Physiol Endocrinol Metab 277: E733-E741, 1999. (Pubitemid 29522627)
28. Treebak JT, Glund S, Deshmukh A, Klein DK, Long YC, Jensen TE, Jørgensen SB, Viollet B, Andersson L, Neumann D, Wallimann T, Richter EA, Chibalin AV, Zierath JR, Wojtaszewski JF. AMPKmediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits. Diabetes 55: 2051-2058, 2006. (Pubitemid 44509979)
29. Wojtaszewski JF, Richter EA. Effects of acute exercise and training on insulin action and sensitivity: focus on molecular mechanisms in muscle. Essays Biochem 42: 31-46, 2006.
30. Wright DC, Fick CA, Olesen JB, Lim K, Barnes BR, Craig BW. A role for calcium/calmodulin kinase in insulin stimulated glucose transport. Life Sci 74: 815-825, 2004. (Pubitemid 37501130)
31. 2+-dependent mechanism in slow-twitch rat soleus muscle. Am J Physiol Endocrinol Metab 288: E1062-E1066, 2005.
32. Wright DC, Hucker KA, Holloszy JO, Han DH. Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions. Diabetes 53: 330-335, 2004.