The combined use of viral transcriptional and post-transcriptional regulatory elements to improve baculovirus-mediated transient gene expression in human embryonic stem cells

Journal of Bioscience and Bioengineering

Volumn 109, Issue 1, 2010, Pages 1-8

  Du, Juan ^a,b   Zeng, Jieming ^a   Zhao, Ying ^a,b   Boulaire, Jerome ^a   Wang, Shu ^a,b  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Baculovirus; Genetic modification; Human embryonic stem cells; Transgene expression; Transient transduction

Indexed keywords

BACULOVIRUS; BIOMEDICAL APPLICATIONS; DEVELOPMENTAL BIOLOGY; ELONGATION FACTOR; EMBRYONIC STEM CELLS; GENETIC MODIFICATIONS; HEPATITIS VIRUS; HUMAN CYTOMEGALOVIRUS; HUMAN EMBRYONIC STEM (HES) CELLS; HUMAN EMBRYONIC STEM CELLS; POST-TRANSCRIPTIONAL; REGULATORY ELEMENTS; SIGNALING PATHWAYS; TRANSGENE EXPRESSION; TRANSIENT EXPRESSION; TRANSIENT GENE EXPRESSIONS; VIRAL VECTORS;

BACTERIOPHAGES; BIOACTIVITY; BIOLOGY; CELL GROWTH; CELL PROLIFERATION; GENE EXPRESSION; GENETIC ENGINEERING;

VECTORS;

BACULOVIRUS VECTOR; ELONGATION FACTOR 1ALPHA;

ARTICLE; BACULOVIRUS; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENHANCER REGION; HEPATITIS VIRUS; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; PROTEIN FUNCTION; REGULATORY SEQUENCE; TRANSIENT EXPRESSION; VIRAL GENE DELIVERY SYSTEM; VIRUS TRANSCRIPTION;

BACULOVIRIDAE; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; CYTOMEGALOVIRUS; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION; GENES, IMMEDIATE-EARLY; GENETIC VECTORS; HEPATITIS B VIRUS, WOODCHUCK; HUMANS; LENTIVIRUS; PEPTIDE ELONGATION FACTOR 1; PROMOTER REGIONS, GENETIC; TERATOMA; TRANSDUCTION, GENETIC; TRANSGENES;

HUMAN HERPESVIRUS 5; WOODCHUCK HEPATITIS VIRUS;

EID: 72249110432     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2009.06.017     Document Type: Article

References (46)

1. Kobayashi N., Rivas-Carrillo J.D., Soto-Gutierrez A., Fukazawa T., Chen Y., Navarro-Alvarez N., and Tanaka N. Gene delivery to embryonic stem cells. Birth Defects Res. C Embryo Today 75 (2005) 10-18
2. Strulovici Y., Leopold P.L., O'Connor T.P., Pergolizzi R.G., and Crystal R.G. Human embryonic stem cells and gene therapy. Mol. Ther. 15 (2007) 850-866
3. Yates F., and Daley G.Q. Progress and prospects: gene transfer into embryonic stem cells. Gene Ther. 13 (2006) 1431-1439
4. Eiges R., Schuldiner M., Drukker M., Yanuka O., Itskovitz-Eldor J., and Benvenisty N. Establishment of human embryonic stem cell-transfected clones carrying a marker for undifferentiated cells. Curr. Biol. 11 (2001) 514-518
5. Lakshmipathy U., Pelacho B., Sudo K., Linehan J.L., Coucouvanis E., Kaufman D.S., and Verfaillie C.M. Efficient transfection of embryonic and adult stem cells. Stem. Cells 22 (2004) 531-543
6. Liew C.G., Draper J.S., Walsh J., Moore H., and Andrews P.W. Transient and stable transgene expression in human embryonic stem cells. Stem. Cells 25 (2007) 1521-1528
7. Siemen H., Nix M., Endl E., Koch P., Itskovitz-Eldor J., and Brustle O. Nucleofection of human embryonic stem cells. Stem Cells. Dev. 14 (2005) 378-383
8. Smith-Arica J.R., Thomson A.J., Ansell R., Chiorini J., Davidson B., and McWhir J. Infection efficiency of human and mouse embryonic stem cells using adenoviral and adeno-associated viral vectors. Cloning Stem Cells 5 (2003) 51-62
9. Ben-Dor I., Itsykson P., Goldenberg D., Galun E., and Reubinoff B.E. Lentiviral vectors harboring a dual-gene system allow high and homogeneous transgene expression in selected polyclonal human embryonic stem cells. Mol. Ther. 14 (2006) 255-267
10. Gropp M., Itsykson P., Singer O., Ben-Hur T., Reinhartz E., Galun E., and Reubinoff B.E. Stable genetic modification of human embryonic stem cells by lentiviral vectors. Mol. Ther. 7 (2003) 281-287
11. Jang J.E., Shaw K., Yu X.J., Petersen D., Pepper K., Lutzko C., and Kohn D.B. Specific and stable gene transfer to human embryonic stem cells using pseudotyped lentiviral vectors. Stem Cells Dev. 15 (2006) 109-117
12. Ma Y., Ramezani A., Lewis R., Hawley R.G., and Thomson J.A. High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors. Stem. Cells 21 (2003) 111-117
13. Pfeifer A., Ikawa M., Dayn Y., and Verma M. Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 2140-2145
14. Xiong C., Tang D.Q., Xie C.Q., Zhang L., Xu K.F., Thompson W.E., Chou W., Gibbons G.H., Chang L.J., Yang L.J., and Chen Y.E. Genetic engineering of human embryonic stem cells with lentiviral vectors. Stem. Cells Dev. 14 (2005) 367-377
15. Hacein-Bey-Abina S., Von Kalle C., Schmidt M., McCormack M.P., Wulffraat N., Leboulch P., Lim A., Osborne C.S., Pawliuk R., Morillon R., et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302 (2003) 415-419
16. Schroder A.R., Shinn P., Chen H., Berry C., Ecker J.R., and Bushman F. HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110 (2002) 521-529
17. Wu X., Li Y., Crise B., and Burgess S.M. Transcription start regions in the human genome are favored targets for MLV integration. Science 300 (2003) 1749-1751
18. Kost T.A., Condreay J.P., and Jarvis D.L. Baculovirus as versatile vectors for protein expression in insect and mammalian cells. Nat. Biotechnol. 23 (2005) 567-575
19. Zeng J., Du J., Zhao Y., Palanisamy N., and Wang S. Baculoviral vector-mediated transient and stable transgene expression in human embryonic stem cells. Stem. Cells 25 (2007) 1055-1061
20. Kost T.A., and Condreay J.P. Recombinant baculoviruses as mammalian cell gene-delivery vectors. Trends Biotechnol. 20 (2002) 173-180
21. Pieroni L., and La Monica N. Towards the use of baculovirus as a gene therapy vector. Curr. Opin. Mol. Ther. 3 (2001) 464-467
22. Wang C.Y., Guo H.Y., Lim T.M., Ng Y.K., Neo H.P., Hwang P.Y., Yee W.C., and Wang S. Improved neuronal transgene expression from an AAV-2 vector with a hybrid CMV enhancer/PDGF-beta promoter. J. Gene. Med. 7 (2005) 945-955
23. Zufferey R., Donello J.E., Trono D., and Hope T.J. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J. Virol. 73 (1999) 2886-2892
24. Loeb J.E., Cordier W.S., Harris M.E., Weitzman M.D., and Hope T.J. Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapy. Hum. Gene Ther. 10 (1999) 2295-2305
25. Chikhlikar P., Barros de Arruda L., Agrawal S., Byrne B., Guggino W., August J.T., and Marques Jr. E.T. Inverted terminal repeat sequences of adeno-associated virus enhance the antibody and CD8(+) responses to a HIV-1 p55Gag/LAMP DNA vaccine chimera. Virology 323 (2004) 220-232
26. Wang C.Y., Li F., Yang Y., Guo H.Y., Wu C.X., and Wang S. Recombinant baculovirus containing the diphtheria toxin A gene for malignant glioma therapy. Cancer Res. 66 (2006) 5798-5806
27. Piersanti S., Martina Y., Cherubini G., Avitabile D., and Saggio I. Use of DNA microarrays to monitor host response to virus and virus-derived gene therapy vectors. Am. J. Pharmacogenomics 4 (2004) 345-356
28. Xia X., Zhang Y., Zieth C.R., and Zhang S.C. Transgenes delivered by lentiviral vector are suppressed in human embryonic stem cells in a promoter-dependent manner. Stem. Cells Dev. 16 (2007) 167-176
29. Gerrard L., Zhao D., Clark A.J., and Cui W. Stably transfected human embryonic stem cell clones express OCT4-specific green fluorescent protein and maintain self-renewal and pluripotency. Stem. Cells 23 (2005) 124-133
30. Kim S., Kim G.J., Miyoshi H., Moon S.H., Ahn S.E., Lee J.H., Lee H.J., Cha K.Y., and Chung H.M. Efficiency of the elongation factor-1alpha promoter in mammalian embryonic stem cells using lentiviral gene delivery systems. Stem. Cells Dev. 16 (2007) 537-545
31. Liu B.H., Wang X., Ma Y.X., and Wang S. CMV enhancer/human PDGF-beta promoter for neuron-specific transgene expression. Gene Ther. 11 (2004) 52-60
32. Sawicki J.A., Morris R.J., Monks B., Sakai K., and Miyazaki J. A composite CMV-IE enhancer/beta-actin promoter is ubiquitously expressed in mouse cutaneous epithelium. Exp. Cell Res. 244 (1998) 367-369
33. Yew N.S., Przybylska M., Ziegler R.J., Liu D., and Cheng S.H. High and sustained transgene expression in vivo from plasmid vectors containing a hybrid ubiquitin promoter. Mol. Ther. 4 (2001) 75-82
34. Niwa H., Yamamura K., and Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108 (1991) 193-199
35. Paterna J.C., and Bueler H. Recombinant adeno-associated virus vector design and gene expression in the mammalian brain. Methods 28 (2002) 208-218
36. Kobayashi M., Tanaka A., Hayashi Y., and Shimamura S. The CMV enhancer stimulates expression of foreign genes from the human EF-1 alpha promoter. Anal. Biochem. 247 (1997) 179-181
37. Klein R.L., Hamby M.E., Gong Y., Hirko A.C., Wang S., Hughes J.A., King M.A., and Meyer E.M. Dose and promoter effects of adeno-associated viral vector for green fluorescent protein expression in the rat brain. Exp. Neurol. 176 (2002) 66-74
38. Xu R., Janson C.G., Mastakov M., Lawlor P., Young D., Mouravlev A., Fitzsimons H., Choi K.L., Ma H., Dragunaw M., et al. Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes. Gene Ther. 8 (2001) 1323-1332
39. Mahonen A.J., Airenne K.J., Purola S., Peltomaa E., Kaikkonen M.U., Riekkinen M.S., Heikura T., Kinnunen K., Roschier M.M., Wirth T., and Yla-Herttuala S. Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells. J. Biotechnol. 131 (2007) 1-8
40. Nightingale S.J., Hollis R.P., Pepper K.A., Petersen D., Yu X.J., Yang C., Bahner I., and Kohn D.B. Transient gene expression by nonintegrating lentiviral vectors. Mol. Ther. 13 (2006) 1121-1132
41. Philippe S., Sarkis C., Barkats M., Mammeri H., Ladroue C., Petit C., Mallet J., and Serguera C. Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 17684-17689
42. Saenz D.T., Loewen N., Peretz M., Whitwam T., Barraza R., Howell K.G., Holmes J.M., Good M., and Poeschla E.M. Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants. J. Virol. 78 (2004) 2906-2920
43. Vargas Jr. J., Gusella G.L., Najfeld V., Klotman M.E., and Cara A. Novel integrase-defective lentiviral episomal vectors for gene transfer. Hum. Gene Ther. 15 (2004) 361-372
44. Yanez-Munoz R.J., Balaggan K.S., MacNeil A., Howe S.J., Schmidt M., Smith A.J., Buch P., MacLaren R.E., Anderson P.N., Barker S.E., et al. Effective gene therapy with nonintegrating lentiviral vectors. Nat. Med. 12 (2006) 348-353
45. Kumar M., Bradow B.P., and Zimmerberg J. Large-scale production of pseudotyped lentiviral vectors using baculovirus GP64. Hum. Gene. Ther. 14 (2003) 67-77
46. Schauber C.A., Tuerk M.J., Pacheco C.D., Escarpe P.A., and Veres G. Lentiviral vectors pseudotyped with baculovirus gp64 efficiently transduce mouse cells in vivo and show tropism restriction against hematopoietic cell types in vitro. Gene Ther. 11 (2004) 266-275