Synthesis and in vivo evaluation of bicyclic gababutins

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 2, 2010, Pages 461-464

  Blakemore, David C ^a   Bryans, Justin S ^a   Carnell, Pauline ^a   Carr, Christopher L ^a   Chessum, Nicola E A ^a   Field, Mark J ^a   Kinsella, Natasha ^a   Osborne, Simon A ^a   Warren, Andrew N ^a   Williams, Sophie C ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Gababutin; Gabapentin; Pain; Pregabalin

Indexed keywords

ANALGESIC AGENT; GABABUTIN; GABAPENTIN; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NEUROPATHIC PAIN; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINES; AMINO ACIDS; ANIMALS; BICYCLO COMPOUNDS; BLOOD-BRAIN BARRIER; CHO CELLS; CRICETINAE; CRICETULUS; CYCLOHEXANECARBOXYLIC ACIDS; GAMMA-AMINOBUTYRIC ACID; NEURALGIA; PAIN MEASUREMENT; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72249097675     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.118     Document Type: Article

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