Autophagy participates in Rotenone-induced dopaminergic neurotoxicity in old rats

Chinese Pharmacological Bulletin

Volumn 25, Issue 9, 2009, Pages

  Hu, Wei Dong ^a   Ke, Guo Xiu ^a   Cheng, Yan Bo ^a   Yang, Ya Ping ^a   Su, Min ^a   Li, Dong Hui ^a   Sun, Xue ^a   Liu, Chun Feng ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Aging; Autophagy; Electron microscopy; LC3; Parkinson's disease; Rotenone

Indexed keywords

ROTENONE;

ARTICLE; AUTOPHAGY; DOPAMINERGIC SYSTEM; NEUROTOXICITY; NONHUMAN;

EID: 72149130917     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Rajawat Y S, Bossis I. Autophagy in aging and in neurodegenerative disorders[J]. Hormones (Athens), 2008,7(1):46-61.
2. Zhao X L, Gu Z L, Qin Z H. Chronic subcutaneous injection of rotenone produces rodent Parkinsonian models [J]. Chin Pharmacol Bull, 2005,21(10):1274-1277
3. Wang X F, Sun S G. Investigation of neuroprotective effect of topiramate on dopaminergic neuron[J]. Stroke New Dis, 2007,14(6):365-368
4. Drechsel D A, Patel M. Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease [J]. Free Radic Biol Med, 2008,44(11):1873-1886
5. Phinney A L, Andringa G, Bol J G, et al. Enhanced sensitivity of dopaminergic neurons to rotenone-induced toxicity with aging[J]. Parkinsonism Relat Disord, 2006,12(4):228-238
6. Shacka J J, Roth K A, Zhang J. The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy[J]. Front Biosci, 2008,13;718-736 (Pubitemid 351599777)
7. Komatsu M, Waguri S, Chiba T, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice [J]. Nature, 2006,441(7095):880-884 (Pubitemid 43910422)
8. Shintani T, Klionsky D J. Autophagy in health and disease: a double-edged sword[J]. Science, 2004,306(5698):990-995 (Pubitemid 39482894)
9. Kurz T, Terman A, Gustafsson B, Brunk U T. Lysosomes and oxidative stress in aging and apoptosis[J]. Biochim Biophys Acta, 2008,1780(11):1291-1303
10. Zhu J H, Horbinski C, Guo F, et al. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4- phenylpyridinium-induced cell death [J]. Am J Pathol, 2007,170(1):75-86. (Pubitemid 47339191)