Effectiveness of 0.50% and 0.75% chlorhexidine dentifrices in orthodontic patients: A double-blind and randomized controlled trial

American Journal of Orthodontics and Dentofacial Orthopedics

Volumn 136, Issue 5, 2009, Pages 651-656

  Oltramari Navarro, Paula Vanessa Pedron ^a   Titarelli, Juliana Mára ^b   Marsicano, Juliane Avansini ^c   Castanha Henriques, José Fernando ^c   Janson, Guilherme ^c   Pereira Lauris, José Roberto ^c   Buzalaf, Marília Afonso Rabelo ^c  

^a UNIVERSIDADE NORTE DO PARANÁ   (Brazil)

^b University of São Paulo ^*

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORHEXIDINE; TOOTHPASTE; TOPICAL ANTIINFECTIVE AGENT;

ADOLESCENT; ADULT; ARTICLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FOLLOW UP; GINGIVA BLEEDING; GINGIVITIS; HUMAN; NONPARAMETRIC TEST; ORTHODONTIC DEVICE; ORTHODONTICS; PERIODONTICS; RANDOMIZED CONTROLLED TRIAL; TOOTH DISCOLORATION; TOOTH PLAQUE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANTI-INFECTIVE AGENTS, LOCAL; CHLORHEXIDINE; DENTAL PLAQUE; DENTIFRICES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FOLLOW-UP STUDIES; GINGIVAL HEMORRHAGE; GINGIVITIS; HUMANS; ORTHODONTIC APPLIANCES; ORTHODONTICS, CORRECTIVE; PERIODONTAL INDEX; STATISTICS, NONPARAMETRIC; TOOTH DISCOLORATION; TREATMENT OUTCOME; YOUNG ADULT;

EID: 72149121585     PISSN: 08895406     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajodo.2008.01.017     Document Type: Article

References (53)

1. Derks A., Kuijpers-Jagtman A.M., Frencken J.E., Van't Hof M.A., and Katsaros C. Caries preventive measures used in orthodontic practices: an evidence-based decision?. Am J Orthod Dentofacial Orthop 132 (2007) 165-170
2. Chang H.S., Walsh L.J., and Freer T.J. Enamel demineralization during orthodontic treatment. Aetiology and prevention. Aust Dent J 42 (1997) 322-327
3. Ogaard B., Rolla G., and Arends J. Orthodontic appliances and enamel demineralization. Part 1. Lesion development. Am J Orthod Dentofacial Orthop 94 (1988) 68-73
4. Olympio K.P., Bardal P., Bastos J., and Buzalaf M. Effectiveness of a chlorhexidine dentifrice in orthodontic patients: a randomized-controlled trial. J Clin Periodontol 33 (2006) 421-426
5. Derks A., Katsaros C., Frencken J.E., van't Hof M.A., and Kuijpers-Jagtman A.M. Caries-inhibiting effect of preventive measures during orthodontic treatment with fixed appliances. A systematic review. Caries Res 38 (2004) 413-420
6. Addy M. Chlorhexidine compared with other locally delivered antimicrobials. A short review. J Clin Periodontol 13 (1986) 957-964
7. Gjermo P. Chlorhexidine in dental practice. J Clin Periodontol 1 (1974) 143-152
8. Rijkom H., Truin G., and Van't Hof M. A meta-analysis of clinical studies on the caries-inhibiting effect of chlorhexidine treatment. J Dent Res 75 (1996) 790-795
9. Law V., and Seow W.K. A longitudinal study of 0.2% chlorhexidine gel for removal of mutans streptococci infection in preschool children. Aust Dent J 52 (2007) 26-32
10. Petti S., and Hausen H. Caries-preventive effect of chlorhexidine gel applications among high-risk children. Caries Res 40 (2006) 514-521
11. Francis J.R., Addy M., and Hunter B.A. A comparison of three delivery methods of chlorhexidine in handicapped children. II. Parent and house-parent preferences. J Periodontol 58 (1987) 456-459
12. Stoeken J.E., Versteeg P.A., Rosema N.A., Timmerman M.F., van der Velden U., and van der Weijden G.A. Inhibition of "de novo" plaque formation with 0.12% chlorhexidine spray compared to 0.2% spray and 0.2% chlorhexidine mouthwash. J Periodontol 78 (2007) 899-904
13. Attin R., Ilse A., Werner C., Wiegand A., and Attin T. Antimicrobial effectiveness of a highly concentrated chlorhexidine varnish treatment in teenagers with fixed orthodontic appliances. Angle Orthod 76 (2006) 1022-1027
14. Attin R., Thon C., Schlagenhauf U., Werner C., Wiegand A., Hannig C., et al. Recolonization of mutans streptococci on teeth with orthodontic appliances after antimicrobial therapy. Eur J Orthod 27 (2005) 489-493
15. Bizhang M., Seemann R., Romhild G., Chun Y.H., Umland N., Lang H., et al. Effect of a 40% chlorhexidine varnish on demineralization of dentin surfaces in situ. Am J Dent 20 (2007) 193-197
16. Cosyn J., and Sabzevar M.M. Subgingival chlorhexidine varnish administration as an adjunct to same-day full-mouth root planing. II. Microbiological observations. J Periodontol 78 (2007) 438-445
17. Cosyn J., Wyn I., De Rouck T., and Sabzevar M.M. Subgingival chlorhexidine varnish administration as an adjunct to same-day full-mouth root planing. I. Clinical observations. J Periodontol 78 (2007) 430-437
18. Du M.Q., Tai B.J., Jiang H., Lo E.C., Fan M.W., and Bian Z. A two-year randomized clinical trial of chlorhexidine varnish on dental caries in Chinese preschool children. J Dent Res 85 (2006) 557-559
19. Altenburger M.J., Klasser M., Schirrmeister J.F., and Hellwig E. Remineralisation of carious enamel lesions after application of a CHX/F-mouthrinse compared with sole CHX- and placebo-application. Oral Health Prev Dent 4 (2006) 255-263
20. Anderson G.B., Bowden J., Morrison E.C., and Caffesse R.G. Clinical effects of chlorhexidine mouthwashes on patients undergoing orthodontic treatment. Am J Orthod Dentofacial Orthop 111 (1997) 606-612
21. Erverdi N., Acar A., Isguden B., and Kadir T. Investigation of bacteremia after orthodontic banding and debanding following chlorhexidine mouthwash application. Angle Orthod 71 (2001) 190-194
22. Lorenz K., Bruhn G., Heumann C., Netuschil L., Brecx M., and Hoffmann T. Effect of two new chlorhexidine mouthrinses on the development of dental plaque, gingivitis, and discolouration. A randomized, investigator-blind, placebo-controlled, 3-week experimental gingivitis study. J Clin Periodontol 33 (2006) 561-567
23. Thrane P.S., Young A., Jonski G., and Rolla G. A new mouthrinse combining zinc and chlorhexidine in low concentrations provides superior efficacy against halitosis compared to existing formulations: a double-blind clinical study. J Clin Dent 18 (2007) 82-86
24. Tomas I., Alvarez M., Limeres J., Tomas M., Medina J., Otero J.L., et al. Effect of a chlorhexidine mouthwash on the risk of postextraction bacteremia. Infect Control Hosp Epidemiol 28 (2007) 577-582
25. Carvalho J., Novak M.J., and Mota L.F. Evaluation of the effect of subgingival placement of chlorhexidine chips as an adjunct to scaling and root planing. J Periodontol 78 (2007) 997-1001
26. Rodrigues I.F., Machion L., Casati M.Z., Nociti Jr. F.H., de Toledo S., Sallum A.W., et al. Clinical evaluation of the use of locally delivered chlorhexidine in periodontal maintenance therapy. J Periodontol 78 (2007) 624-628
27. Cosyn J., and Verelst K. An efficacy and safety analysis of a chlorhexidine chewing gum in young orthodontic patients. J Clin Periodontol 33 (2006) 894-899
28. Dolles O., and Gjermo P. Caries increment and gingival status during 2 years use of chlorhexidine and fluoride containing dentifrices. Scand J Dent Res 88 (1980) 22-27
29. Yates R., Jenkins S., Newcombe R., Wade W., Moran J., and Addy M.A. 6-month home usage trial of a 1% chlorhexidine toothpaste. J Clin Periodontol 20 (1993) 130-138
30. Claydon N., Manning C.M., Darby-Dowman A., Ridge D., Smith S., and Addy M. The effect of polyvinyl pyrrolidone on the clinical activity of 0.09% and 0.2% chlorhexidine mouthrinses. J Clin Periodontol 28 (2001) 1037-1044
31. Claydon N., Smith S., Stiller S., Newcombe R.G., and Addy M. A comparison of the plaque-inhibitory properties of stannous fluoride and low-concentration chlorhexidine mouthrinses. J Clin Periodontol 29 (2002) 1072-1077
32. Ernst C.P., Prockl K., and Willershausen B. The effectiveness and side effects of 0.1% and 0.2% chlorhexidine mouthrinses: a clinical study. Quintessence Int 29 (1998) 443-448
33. Addy M., Willis L., and Moran J. The effect of tooth paste rinses compared with clorhexidine on plaque formation during a 4-day period. J Clin Periodontol 10 (1983) 89-99
34. Greene J.C., and Vermilloin J. The simplified oral hygiene index. J Am Dent Assoc 68 (1964) 7-13
35. Löe H., and Silness J. Periodontal disease in pregnancy. Acta Odontol Scand 21 (1963) 533-551
36. Ainamo J., and Bay I. Problems and proposals for recording gingivitis and plaque. Scand J Dent Res 25 (1975) 229-235
37. Heintze S.D., Jost-Brinkmann P.G., Finke C., and Miethke R.R. Evaluation of oral health and measurement of risk. In: Heintze S.D., Finke C., Jost-Brinkmann P.G., and Miethke R.R. (Eds). Oral health for the orthodontic patient (1998), Quintessence, Chicago 25-43
38. Leard A., and Addy M. The propensity of different brands of tea and coffee to cause staining associated with chlorhexidine. J Clin Periodontol 24 (1997) 115-118
39. Sanz M., Vallcorba N., Fabregues S., Muller I., and Herkstroter F. The effect of a dentifrice containing chlorhexidine and zinc on plaque, gingivitis, calculus and tooth staining. J Clin Periodontol 21 (1994) 431-437
40. Lang N.P., Holtz P., Graf H., Geering A.H., Saxer U.P., Sturzenberger O.P., et al. Effects of supervised chlorhexidine mouthrinses in children. J Periodontol Res 17 (1982) 101-111
41. Grossman E., Reiter G., Sturzenberger O.P., Rosa M.D.L., Dickenson T.D., Ferretti G.A., et al. Six month study of the effects of a chlorhexidine mouthrinse on gingivitis in adults. J Periodontol Res 21 (1986) 33-43
42. Mandell I.D. Chemotherapeutic agents for controlling plaque and gingivitis. J Clin Periodontol 15 (1988) 488-498
43. Gjermo P., and Rolla G. The plaque-inhibiting effect of chlorhexidine-containing dentifrices. Scand J Dent Res 79 (1971) 126-132
44. Addy M., Wade W., Jenkins S., and Goodfield S. Comparison of two commercially available mouthrinses: I. Staining and antimicrobial effects in vitro. Clin Prev Dent 11 (1989) 10-14
45. Flotra L. Different modes of chlorexidine application and related local side effects. J Periodontol Res 8 (1973) 41-44
46. Flotra L., Gjermo P., Rolla G., and Waerhaug J. Side effects of chlorhexidine mouthwashes. Scand J Dent Res 79 (1971) 119-125
47. Jenkins S., Addy M., and Newcombe R. Comparison of two commercially available chlorhexidine mouthrinses: II. Effects on plaque reformation, gingivitis, and tooth staining. Clin Prev Dent 11 (1989) 12-16
48. Jenkins S., Addy M., and Newcombe R. The effects of a chlorhexidine toothpaste on the development of plaque, gingivitis, and tooth staining. J Clin Periodontol 20 (1993) 59-62
49. Löe H., and Schiott C.R. The effect of mouthrinses and topical applications of chlorhexidine on the development of dental plaque and gingivitis in man. J Periodontol Res 5 (1970) 79-83
50. Cancro C.P., Paulovich D.B., Klein K., and Picozzi A. Effects of a chlorhexidine gluconate mouthrinse on dental plaque and calculus. J Periodontol 43 (1972) 687-691
51. Löe H., Mandell M., Derry A., and Schott C.R. The effect of mouthrinses and topical application of chlorhexidine on calculus formation in man. J Periodontal Res 6 (1971) 312-314
52. Löe H., Schiött C., Karring C., and Karring T. Two years oral use of chlorhexidine in man. I. General design and clinical effects. J Periodontol Res 11 (1976) 135-144
53. Johansen J., Gjermo P., and Eriksen H. Effect of two years use of chlorhexidine containing dentifrices on plaque, gingivitis and caries. Scand J Dent Res 83 (1975) 288-292