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Volumn 58, Issue 11, 2009, Pages 1144-1149

What do we know about anesthetic mechanisms?: Hypnosis, unresponsiveness to surgical incision and amnesia;Was wissen wir über narkosemechanismen?: Bewusstlosigkeit, bewegungslosigkeit und amnesie

Author keywords

Ion channels; Isoflurane; Ketamine; Mechanisms of anesthesia; Propofol

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; GLUTAMATE RECEPTOR; GLYCINE RECEPTOR; ION CHANNEL; ISOFLURANE; KETAMINE; NICOTINIC RECEPTOR; PROPOFOL; SEROTONIN RECEPTOR;

EID: 72149118452     PISSN: 00032417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00101-009-1618-9     Document Type: Review
Times cited : (12)

References (50)
  • 1
    • 0034268955 scopus 로고    scopus 로고
    • Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness
    • Alkire MT, Haier RJ, Fallon JH (2000) Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness. Conscious Cogn 9:370-386
    • (2000) Conscious Cogn , vol.9 , pp. 370-386
    • Alkire, M.T.1    Haier, R.J.2    Fallon, J.H.3
  • 2
    • 34547598476 scopus 로고    scopus 로고
    • Thalamic microinjection of nicotine reversessevoflurane-induced loss of righting reflex in the rat
    • Alkire MT, McReynolds JR, Hahn EL, Trivedi AN (2007) Thalamic microinjection of nicotine reversessevoflurane-induced loss of righting reflex in the rat. Anesthesiology 107:264-272
    • (2007) Anesthesiology , vol.107 , pp. 264-272
    • Alkire, M.T.1    McReynolds, J.R.2    Hahn, E.L.3    Trivedi, A.N.4
  • 3
    • 0020629581 scopus 로고
    • The dissociative anaesthetics, ketamine and phencyclidine,selectively reduce excitation of central mammalianneurones by N-methyl-aspartate
    • Anis NA, Berry SC, Burton NR, Lodge D (1983) The dissociative anaesthetics, ketamine and phencyclidine,selectively reduce excitation of central mammalianneurones by N-methyl-aspartate. Br J Pharmacol79:565-575
    • (1983) Br J Pharmacol , vol.79 , pp. 565-575
    • Anis, N.A.1    Berry, S.C.2    Burton, N.R.3    Lodge, D.4
  • 4
    • 0026062013 scopus 로고
    • Subhypnotic doses of thiopentone and propofol cause analgesia to experimentally inducedacute pain
    • Anker-Møller E, Spangsberg N, Arendt-Nielsen L et al (1991) Subhypnotic doses of thiopentone and propofol cause analgesia to experimentally inducedacute pain. Br J Anaesth 66:185-188
    • (1991) Br J Anaesth , vol.66 , pp. 185-188
    • Anker-Møller, E.1    Spangsberg, N.2    Arendt-Nielsen, L.3
  • 5
    • 0027136076 scopus 로고
    • Exaggerated anesthetic requirements in the preferentially anesthetized brain
    • Antognini JF, Schwartz K (1993) Exaggerated anesthetic requirements in the preferentially anesthetized brain. Anesthesiology 79:1244-1249
    • (1993) Anesthesiology , vol.79 , pp. 1244-1249
    • Antognini, J.F.1    Schwartz, K.2
  • 6
    • 0034018492 scopus 로고    scopus 로고
    • Inhibitionof 5-HT3 receptors by propofol: equilibrium and kinetic measurements
    • Barann M, Dilger JP, Boenisch H et al (2000) Inhibitionof 5-HT3 receptors by propofol: equilibrium and kinetic measurements. Neuropharmacology 39:1064-1074
    • (2000) Neuropharmacology , vol.39 , pp. 1064-1074
    • Barann, M.1    Dilger, J.P.2    Boenisch, H.3
  • 7
    • 54349104413 scopus 로고    scopus 로고
    • Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact
    • Bayliss DA, Barrett PQ (2008) Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact. Trends Pharmacol Sci 29:566-575
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 566-575
    • Bayliss, D.A.1    Barrett, P.Q.2
  • 8
    • 0026439938 scopus 로고
    • General anaesthetics inhibitthe responses induced by glutamate receptoragonists in the mouse cortex
    • Carlà V, Moroni F (1992) General anaesthetics inhibitthe responses induced by glutamate receptoragonists in the mouse cortex. Neurosci Lett 146:21-24
    • (1992) Neurosci Lett , vol.146 , pp. 21-24
    • Carlà, V.1    Moroni, F.2
  • 9
    • 58849126604 scopus 로고    scopus 로고
    • HCN1 channel subunits are a molecular substrate for hypnotic actionsof ketamine
    • Chen X, Shu S, Bayliss DA (2009) HCN1 channel subunits are a molecular substrate for hypnotic actionsof ketamine. J Neurosci 29:600-609
    • (2009) J Neurosci , vol.29 , pp. 600-609
    • Chen, X.1    Shu, S.2    Bayliss, D.A.3
  • 10
    • 58849162825 scopus 로고    scopus 로고
    • Subunit-specific effects of isoflurane on neuronal Ih in HCN1 knockout mice
    • Chen X, Shu S, Kennedy DP et al (2009) Subunit-specific effects of isoflurane on neuronal Ih in HCN1 knockout mice. J Neurophysiol 101:129-140
    • (2009) J Neurophysiol , vol.101 , pp. 129-140
    • Chen, X.1    Shu, S.2    Kennedy, D.P.3
  • 11
    • 20544443035 scopus 로고    scopus 로고
    • HCN subunit-specific and cAMP-modulated effects of anestheticson neuronal pacemaker currents
    • Chen X, Sirois JE, Lei Q et al (2005) HCN subunit-specific and cAMP-modulated effects of anestheticson neuronal pacemaker currents. J Neurosci 25:5803-5814
    • (2005) J Neurosci , vol.25 , pp. 5803-5814
    • Chen, X.1    Sirois, J.E.2    Lei, Q.3
  • 12
    • 0029085817 scopus 로고
    • Concentrations of desflurane and propofol that suppress response to command in humans
    • Chortkoff BS, Eger EI 2nd, Crankshaw DP et al (1995) Concentrations of desflurane and propofol that suppress response to command in humans. Anesth Analg 81:737-743
    • (1995) Anesth Analg , vol.81 , pp. 737-743
    • Chortkoff, B.S.1    Eger II, E.I.2    Crankshaw, D.P.3
  • 13
    • 0029149509 scopus 로고
    • Subanesthetic concentrations of desflurane and propofol suppress recall of emotionally chargedinformation
    • Chortkoff BS, Gonsowski CT, Bennett HL et al (1995) Subanesthetic concentrations of desflurane and propofol suppress recall of emotionally chargedinformation. Anesth Analg 81:728-736
    • (1995) Anesth Analg , vol.81 , pp. 728-736
    • Chortkoff, B.S.1    Gonsowski, C.T.2    Bennett, H.L.3
  • 14
    • 0013815474 scopus 로고
    • Minimumalveolar anesthetic concentration: a standardof anesthetic potency
    • Eger EI 2nd, Saidman LJ, Brandstater B (1965) Minimumalveolar anesthetic concentration: a standardof anesthetic potency. Anesthesiology 26:756-763
    • (1965) Anesthesiology , vol.26 , pp. 756-763
    • Eger II, E.I.1    Saidman, L.J.2    Brandstater, B.3
  • 15
    • 0031003845 scopus 로고    scopus 로고
    • Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected
    • Flood P, Ramirez-Latorre J, Role L (1997) Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected. Anesthesio-logy 86:859-865
    • (1997) Anesthesio-logy , vol.86 , pp. 859-865
    • Flood, P.1    Ramirez-Latorre, J.2    Role, L.3
  • 16
    • 42349089480 scopus 로고    scopus 로고
    • General anaesthesia: from moleculartargets to neuronal pathways of sleep and arousal
    • Franks NP (2008) General anaesthesia: from moleculartargets to neuronal pathways of sleep and arousal. Nat Rev Neurosci 9:370-386
    • (2008) Nat Rev Neurosci , vol.9 , pp. 370-386
    • Franks, N.P.1
  • 17
    • 33749441324 scopus 로고    scopus 로고
    • Anaesthetic drugs: linking molecular actionsto clinical effects
    • Grasshoff C, Drexler B, Rudolph U, Antkowiak B (2006) Anaesthetic drugs: linking molecular actionsto clinical effects. Curr Pharm Des 12:3665-3679
    • (2006) Curr Pharm Des , vol.12 , pp. 3665-3679
    • Grasshoff, C.1    Drexler, B.2    Rudolph, U.3    Antkowiak, B.4
  • 18
    • 23044492151 scopus 로고    scopus 로고
    • Molecularand systemic mechanisms of general anaesthesia:the "multi-site and multiple mechanisms" concept
    • Grasshoff C, Rudolph U, Antkowiak B (2005) Molecularand systemic mechanisms of general anaesthesia:the "multi-site and multiple mechanisms" concept. Curr Opin Anaesthesiol 18:386-391
    • (2005) Curr Opin Anaesthesiol , vol.18 , pp. 386-391
    • Grasshoff, C.1    Rudolph, U.2    Antkowiak, B.3
  • 19
    • 0025986811 scopus 로고
    • The actions of propofolon inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent centralneurones
    • Hales TG, Lambert JJ (1991) The actions of propofolon inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent centralneurones. Br J Pharmacol 104:619-628
    • (1991) Br J Pharmacol , vol.104 , pp. 619-628
    • Hales, T.G.1    Lambert, J.J.2
  • 20
    • 0027282161 scopus 로고
    • Positivemodulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane
    • Harrison NL, Kugler JL, Jones MV et al (1993) Positivemodulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane. Mol Pharmacol 44:628-632
    • (1993) Mol Pharmacol , vol.44 , pp. 628-632
    • Harrison, N.L.1    Kugler, J.L.2    Jones, M.V.3
  • 21
    • 45149115876 scopus 로고    scopus 로고
    • Volatile anesthetic effects on midbrain-elicited locomotion suggest that the locomotor network in the ventral spinal cord is the primary site for immobility
    • Jinks SL, Bravo M, Hayes SG (2008) Volatile anesthetic effects on midbrain-elicited locomotion suggest that the locomotor network in the ventral spinal cord is the primary site for immobility. Anesthesiology108:1016-1024
    • (2008) Anesthesiology , vol.108 , pp. 1016-1024
    • Jinks, S.L.1    Bravo, M.2    Hayes, S.G.3
  • 22
    • 22144462098 scopus 로고    scopus 로고
    • Differentkinetic properties of two T-type Ca2+ currents of rat reticular thalamic neurones and their modulationby enflurane
    • Joksovic PM, Bayliss DA, Todorovic SM (2005) Differentkinetic properties of two T-type Ca2+ currents of rat reticular thalamic neurones and their modulationby enflurane. J Physiol 566:125-142
    • (2005) J Physiol , vol.566 , pp. 125-142
    • Joksovic, P.M.1    Bayliss, D.A.2    Todorovic, S.M.3
  • 23
    • 13244289824 scopus 로고    scopus 로고
    • Contrasting anesthetic sensitivities of T-typeCa2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channels
    • Joksovic PM, Brimelow BC, Murbartián J et al (2005) Contrasting anesthetic sensitivities of T-typeCa2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channels. Br J Pharmacol 144:59-70
    • (2005) Br J Pharmacol , vol.144 , pp. 59-70
    • Joksovic, P.M.1    Brimelow, B.C.2    Murbartián, J.3
  • 24
    • 0033567181 scopus 로고    scopus 로고
    • General anaestheticactions on ligand-gated ion channels
    • Krasowski MD, Harrison NL (1999) General anaestheticactions on ligand-gated ion channels. Cell Mol Life Sci 55:1278-1303
    • (1999) Cell Mol Life Sci , vol.55 , pp. 1278-1303
    • Krasowski, M.D.1    Harrison, N.L.2
  • 25
    • 0026471363 scopus 로고
    • Generalanesthetics potentiate gamma-aminobutyricacid actions on gamma-aminobutyric acid A receptorsexpressed by Xenopus oocytes: lack of involvementof intracellular calcium
    • Lin LH, Chen LL, Zirrolli JA, Harris RA (1992) Generalanesthetics potentiate gamma-aminobutyricacid actions on gamma-aminobutyric acid A receptorsexpressed by Xenopus oocytes: lack of involvementof intracellular calcium. J Pharmacol Exp Ther 263:569-578
    • (1992) J Pharmacol Exp Ther , vol.263 , pp. 569-578
    • Lin, L.H.1    Chen, L.L.2    Zirrolli, J.A.3    Harris, R.A.4
  • 26
    • 34547844286 scopus 로고    scopus 로고
    • Propofol inhibits HCN1 pacemaker channels by selectiveassociation with the closed states of the membrane embedded channel core
    • Lyashchenko AK, Redd KJ, Yang J, Tibbs GR (2007) Propofol inhibits HCN1 pacemaker channels by selectiveassociation with the closed states of the membrane embedded channel core. J Physiol 583:37-56
    • (2007) J Physiol , vol.583 , pp. 37-56
    • Lyashchenko, A.K.1    Redd, K.J.2    Yang, J.3    Tibbs, G.R.4
  • 27
    • 0025970493 scopus 로고
    • Actionsof ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampalneuron
    • MacDonald JF, Bartlett MC, Mody I et al (1991) Actionsof ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampalneuron. J Physiol 432:483-508
    • (1991) J Physiol , vol.432 , pp. 483-508
    • MacDonald, J.F.1    Bartlett, M.C.2    Mody, I.3
  • 29
    • 0032478602 scopus 로고    scopus 로고
    • Sites of volatile anesthetic action on kainate (glutamate receptor 6) receptors
    • Minami K, Wick MJ, Stern-Bach Y et al (1998) Sites of volatile anesthetic action on kainate (glutamate receptor 6) receptors. J Biol Chem 273:8248-8255
    • (1998) J Biol Chem , vol.273 , pp. 8248-8255
    • Minami, K.1    Wick, M.J.2    Stern-Bach, Y.3
  • 30
    • 0029162568 scopus 로고
    • Inhibition by propofol (2,6 di-isopropylphenol) of the N-methyl-D-aspartate subtype of glutamate receptor in cultured hippocampal neurones
    • Orser BA, Bertlik M, Wang LY, MacDonald JF (1995) Inhibition by propofol (2,6 di-isopropylphenol) of the N-methyl-D-aspartate subtype of glutamate receptor in cultured hippocampal neurones. Br J Pharmacol 116:1761-1768
    • (1995) Br J Pharmacol , vol.116 , pp. 1761-1768
    • Orser, B.A.1    Bertlik, M.2    Wang, L.Y.3    MacDonald, J.F.4
  • 31
    • 0028081408 scopus 로고
    • Propofol modulates activation and desensitizationof GABAA receptors in cultured murine hippocampal neurons
    • Orser BA, Wang LY, Pennefather PS, MacDonald JF (1994) Propofol modulates activation and desensitizationof GABAA receptors in cultured murine hippocampal neurons. J Neurosci 14:7747-7760
    • (1994) J Neurosci , vol.14 , pp. 7747-7760
    • Orser, B.A.1    Wang, L.Y.2    Pennefather, P.S.3    MacDonald, J.F.4
  • 32
    • 13244297155 scopus 로고    scopus 로고
    • Working memory in primate sensory systems
    • Pasternak T, Greenlee MW (2005) Working memory in primate sensory systems. Nat Rev Neurosci 6:97-107
    • (2005) Nat Rev Neurosci , vol.6 , pp. 97-107
    • Pasternak, T.1    Greenlee, M.W.2
  • 33
    • 0033366538 scopus 로고    scopus 로고
    • Inhalationalanesthetics activate two-pore-domain background K+ channels
    • Patel AJ, Honoré E, Lesage F et al (1999) Inhalationalanesthetics activate two-pore-domain background K+ channels. Nat Neurosci 2:422-426
    • (1999) Nat Neurosci , vol.2 , pp. 422-426
    • Patel, A.J.1    Honoré, E.2    Lesage, F.3
  • 34
    • 0037207469 scopus 로고    scopus 로고
    • Molecular physiology of low-voltage-activated T-type calcium channels
    • Perez-Reyes E (2002) Molecular physiology of low-voltage-activated T-type calcium channels. Physiol Rev 83:117-161
    • (2002) Physiol Rev , vol.83 , pp. 117-161
    • Perez-Reyes, E.1
  • 35
    • 35048877549 scopus 로고    scopus 로고
    • Differential effects of volatile and intravenous anesthetics on the activity of human TASK-1
    • Putzke C, Hanley PJ, SchlichthörlG et al (2007) Differential effects of volatile and intravenous anesthetics on the activity of human TASK-1. Am J Physiol Cell Physiol 293:1319-1326
    • (2007) Am J Physiol Cell Physiol , vol.293 , pp. 1319-1326
    • Putzke, C.1    Hanley, P.J.2    Schlichthörl, G.3
  • 36
    • 0028297603 scopus 로고
    • Anesthetic potency is not altered after hypothermic spinal cord transection in rats
    • Rampil IJ (1994) Anesthetic potency is not altered after hypothermic spinal cord transection in rats. Anesthesiology 80:606-610
    • (1994) Anesthesiology , vol.80 , pp. 606-610
    • Rampil, I.J.1
  • 37
    • 0027467413 scopus 로고
    • Anesthetic potency(MAC) is independent of forebrain structures in the rat
    • Rampil IJ, Mason P, Singh H (1993) Anesthetic potency(MAC) is independent of forebrain structures in the rat. Anesthesiology 78:707-712
    • (1993) Anesthesiology , vol.78 , pp. 707-712
    • Rampil, I.J.1    Mason, P.2    Singh, H.3
  • 38
    • 4544312085 scopus 로고    scopus 로고
    • Isoflurane modulates glutamatergic and GABAergic neurotransmissionin the amygdala
    • Ranft A, Kurz J, Deuringer M et al (2004) Isoflurane modulates glutamatergic and GABAergic neurotransmissionin the amygdala. Eur J Neurosci 20:1276-1280
    • (2004) Eur J Neurosci , vol.20 , pp. 1276-1280
    • Ranft, A.1    Kurz, J.2    Deuringer, M.3
  • 39
    • 0035996639 scopus 로고    scopus 로고
    • Anaesthetic actionson other targets: protein kinase C and guaninenucleotide-binding proteins
    • Rebecchi MJ, Pentyala SN (2002) Anaesthetic actionson other targets: protein kinase C and guaninenucleotide-binding proteins. Br J Anaesth 89:62-78
    • (2002) Br J Anaesth , vol.89 , pp. 62-78
    • Rebecchi, M.J.1    Pentyala, S.N.2
  • 40
    • 4344574333 scopus 로고    scopus 로고
    • Molecular and neuronal substrates for general anaesthetics
    • Rudolph U, Antkowiak B (2004) Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci 5:709-720
    • (2004) Nat Rev Neurosci , vol.5 , pp. 709-720
    • Rudolph, U.1    Antkowiak, B.2
  • 41
    • 24944583652 scopus 로고    scopus 로고
    • Isofluraneexerts antinociceptive and hypnotic propertiesat all ages in Fischer rats
    • Sanders RD, Patel N, Hossain M et al (2005) Isofluraneexerts antinociceptive and hypnotic propertiesat all ages in Fischer rats. Br J Anaesth 95:393-399
    • (2005) Br J Anaesth , vol.95 , pp. 393-399
    • Sanders, R.D.1    Patel, N.2    Hossain, M.3
  • 42
    • 0034981774 scopus 로고    scopus 로고
    • Isoflurane blocks synaptic plasticity in the mouse hippocampus
    • Simon W, Hapfelmeier G, Kochs E et al (2001) Isoflurane blocks synaptic plasticity in the mouse hippocampus. Anesthesiology 94:1058-1065
    • (2001) Anesthesiology , vol.94 , pp. 1058-1065
    • Simon, W.1    Hapfelmeier, G.2    Kochs, E.3
  • 43
    • 0028043659 scopus 로고
    • The interactionof fentanyl on the Cp50 of propofol for loss of consciousness and skin incision
    • Smith C, McEwan AI, Jhaveri R et al (1994) The interactionof fentanyl on the Cp50 of propofol for loss of consciousness and skin incision. Anesthesiology 81:820-828
    • (1994) Anesthesiology , vol.81 , pp. 820-828
    • Smith, C.1    McEwan, A.I.2    Jhaveri, R.3
  • 44
    • 34447320197 scopus 로고    scopus 로고
    • Correlating the clinical actions and molecular mechanisms of general anesthetics
    • Solt K, Forman SA (2007) Correlating the clinical actions and molecular mechanisms of general anesthetics. Curr Opin Anaesthesiol 20:300-306
    • (2007) Curr Opin Anaesthesiol , vol.20 , pp. 300-306
    • Solt, K.1    Forman, S.A.2
  • 45
    • 0027445242 scopus 로고
    • Thalamocortical oscillations in the sleeping and aroused brain
    • Steriade M, McCormick DA, Sejnowski TJ (1993) Thalamocortical oscillations in the sleeping and aroused brain. Science 262:679-685
    • (1993) Science , vol.262 , pp. 679-685
    • Steriade, M.1    McCormick, D.A.2    Sejnowski, T.J.3
  • 46
    • 0033948991 scopus 로고    scopus 로고
    • Anticonvulsantsbut not general anesthetics have differentialblocking effects on different T-type currentvariants
    • Todorovic SM, Perez-Reyes E, Lingle CJ (2000) Anticonvulsantsbut not general anesthetics have differentialblocking effects on different T-type currentvariants. Mol Pharmacol 58:98-108
    • (2000) Mol Pharmacol , vol.58 , pp. 98-108
    • Todorovic, S.M.1    Perez-Reyes, E.2    Lingle, C.J.3
  • 47
    • 0034126875 scopus 로고    scopus 로고
    • Subunit-dependent inhibition of human neuronalnicotinic acetylcholine receptors and other ligand-gated ion channels by dissociative anestheticsketamine and dizocilpine
    • Yamakura T, Chavez-Noriega LE, Harris RA (2000) Subunit-dependent inhibition of human neuronalnicotinic acetylcholine receptors and other ligand-gated ion channels by dissociative anestheticsketamine and dizocilpine. Anesthesiology 92:1144-1153
    • (2000) Anesthesiology , vol.92 , pp. 1144-1153
    • Yamakura, T.1    Chavez-Noriega, L.E.2    Harris, R.A.3
  • 48
    • 0028926623 scopus 로고
    • Effects of propofol on various AMPA-, kainate-and NMDA-selective glutamate receptor channels expressed in Xenopus oocytes
    • Yamakura T, Sakimura K, Shimoji K, Mishina M (1995) Effects of propofol on various AMPA-, kainate-and NMDA-selective glutamate receptor channels expressed in Xenopus oocytes. Neurosci Lett 188:187-190
    • (1995) Neurosci Lett , vol.188 , pp. 187-190
    • Yamakura, T.1    Sakimura, K.2    Shimoji, K.3    Mishina, M.4
  • 49
    • 33644958425 scopus 로고    scopus 로고
    • Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons
    • Ying SW, Abbas SY, Harrison NL, Goldstein PA (2006) Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons. Eur J Neurosci23:465-480
    • (2006) Eur J Neurosci , vol.23 , pp. 465-480
    • Ying, S.W.1    Abbas, S.Y.2    Harrison, N.L.3    Goldstein, P.A.4
  • 50
    • 0031025811 scopus 로고    scopus 로고
    • Volatile generalanaesthetic actions on recombinant nACh alpha7, 5-HT3 and chimeric nACh alpha 7-5-HT3 receptorsexpressed in Xenopus oocytes
    • Zhang L, Oz M, Stewart RR et al (1997) Volatile generalanaesthetic actions on recombinant nACh alpha7, 5-HT3 and chimeric nACh alpha 7-5-HT3 receptorsexpressed in Xenopus oocytes. Br J Pharmacol 120:353-355
    • (1997) Br J Pharmacol , vol.120 , pp. 353-355
    • Zhang, L.1    Oz, M.2    Stewart, R.R.3


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