Protective effects of Chlorpromazine and Verapamil against cadmium-induced kidney damage in vivo

Experimental and Toxicologic Pathology

Volumn 62, Issue 1, 2010, Pages 27-34

  Xu, Bin ^a   Xu, Zhao Fa ^a   Deng, Yu ^a   Yang, Jing Hua ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Cadmium; Chlorpromazine; Kidney damage; Verapamil

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALKALINE PHOSPHATASE; CADMIUM; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; CALMODULIN; CHLORPROMAZINE; GLUTATHIONE; MALONALDEHYDE; N ACETYLGLUCOSAMINE; PROTEIN KINASE C; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; IN VIVO STUDY; KIDNEY CORTEX; KIDNEY INJURY; MALE; NONHUMAN; OXIDATION; RANDOMIZATION; RAT; URINE LEVEL; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; CADMIUM; CADMIUM POISONING; CALCIUM CHANNEL BLOCKERS; CALCIUM-TRANSPORTING ATPASES; CHLORPROMAZINE; FEMALE; KIDNEY; KIDNEY CORTEX; MALE; RATS; RATS, WISTAR; SODIUM-POTASSIUM-EXCHANGING ATPASE; VERAPAMIL;

RATTUS; RATTUS NORVEGICUS;

EID: 72149094843     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2008.12.009     Document Type: Article

References (33)

1. Babu K.R., Rajmohan H.R., Rajan B.K., and Kumar K.M. Plasma lipid peroxidation and erythrocyte antioxidant enzymes status in workers exposed to cadmium. Toxicol Ind Health 22 (2006) 329-335
2. Beutler E., Duron O., and Kelly B.M. Improved method for the determination of blood glutathione. J Lab Clin Med 61 (1963) 882-888
3. Blazka M.E., and Shaikh Z.A. Differences in cadmium and mercury uptakes by hepatocytes: role of calcium channels. Toxicol Appl Pharmacol 110 (1991) 355-363
4. Brzóska M.M., Kamiński M., Supernak-Bobko D., Zwierz K., and Moniuszko-Jakoniuk J. Changes in the structure and function of the kidney of rats chronically exposed to cadmium. I. Biochemical and histopathological studies. Arch Toxicol 77 (2003) 344-352
5. Carfagna M.A., Ponsler G.D., and Muhoberac B.B. Inhibition of ATPase activity in rat synaptic plasma membranes by simultaneous exposure to metals. Chem Biol Interact 100 (1996) 53-65
6. Dwivedi Y., and Pandey G.N. Effects of treatment with haloperidol, chlorpromazine, and clozapine on protein kinase C (PKC) and phosphoinositide-specific phospholipase C (PI-PLC) activity and on mRNA and protein expression of PKC and PLC isozymes in rat brain. J Pharmacol Exp Ther 291 (1999) 688-704
7. El-Ashmawy I.M., and Youssef S.A. The antagonistic effect of chlorpromazine on cadmium toxicity. Toxicol Appl Pharmacol 161 (1999) 34-39
8. Gregoryj L. The effect of cadmium on cytosolic free calcium, protein kinase C, and collagen synthesis in rat osteosarcoma (ROS 17/2.8) cells. Toxicol Appl Pharmacol 143 (1997) 189-195
9. Heinegård D., and Tiderström G. Determination of serum creatinine by a direct colorimetric method. Clin Chim Acta 43 (1973) 305-310
10. Huff J., Lunn R.M., Waalkes M.P., Tomatis L., and Infante P.F. Cadmium-induced cancers in animals and in humans. Int J Occup Environ Health 13 (2007) 202-212
11. Joseph P., Muchnok T.K., Klishis M.L., Roberts J.R., Antonini J.M., Whong W.Z., et al. Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species. Toxicol Sci 61 (2001) 295-303
12. Kakkar P., Das B., and Viswanathan P.N. A modified spectroscopic assay of superoxide dismutase. Indian J Biochem Biophys 21 (1984) 130-132
13. Kei S. Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chem Acta 90 (1978) 37-43
14. Kumar O., Sugendran K., and Vijayaraghavan R. Oxidative stress associated hepatic and renal toxicity induced by ricin in mice. Toxicon 41 (2003) 333-338
15. Låg M., Refsnes M., Lilleaas E.M., Holme J.A., Becher R., and Schwarze P.E. Role of mitogen activated protein kinases and protein kinase C in cadmium-induced apoptosis of primary epithelial lung cells. Toxicology 211 (2005) 253-264
16. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 193 (1951) 265-275
17. Miyahara T., Katoh T., Watanabe M., Mikami Y., Uchida S., Hosoe M., et al. Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells. Toxicology 200 (2004) 159-167
18. Murugavel P., and Pari L. Effects of diallyl tetrasulfide on cadmium-induced oxidative damage in the liver of rats. Hum Exp Toxicol 26 (2007) 527-534
19. Oláh Z., Jósvay K., Pecze L., Letoha T., Babai N., Budai D., et al. Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel. PLOS One 2 (2007) e545
20. Piscator M. The nephropathy of chronic cadmium poisoning. In: Foulkes E.C. (Ed). Handbook of experimental pharmacology (1986), New York, Springer 180-194
21. Rotruck J.T., Pope A.L., and Ganther H.E. Selenium: biochemical role as a component of glutathione peroxidase purification assay. Science 179 (1973) 588-590
22. Sabolic I., Ljubojevic M., Herak-Kramberger C.M., and Brown D. Cd-MT causes endocytosis of brush-border transporters in rat renal proximal tubules. Am J Physiol Renal Physiol 283 (2002) 1389-1402
23. Siniscalchi A., Marino S., Marani L., Piubello C., Bianchi C., and Selvatici R. Early and delayed glutamate effects in rat primary cortical neurons changes in the subcellular distribution of protein kinase C isoforms and in intracellular calcium concentration. Neurochem Int 46 (2005) 117-125
24. Souza V., Bucio L., and Gutierrez-Ruiz M.C. Cadmium uptake by a human hepatic cell line (WRL-68 cells). Toxicology 120 (1997) 215-220
25. Suzuki N., Yamamoto M., Watanabe K., Kambegawa A., and Hattori A. Both mercury and cadmium directly influence calcium homeostasis resulting from the suppression of scale bone cells: the scale is a good model for the evaluation of heavy metals in bone metabolism. J Bone Miner Metab 22 (2004) 439-446
26. 2+-ATPase in PC12 cells. Cell Mol Biol Lett 9 (2004) 451-464
27. Szuster-Ciesielska A., Stachura A., Słotwińska M., Kamińska T., Sniezko R., Paduch R., et al. The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures. Toxicology 145 (2000) 159-171
28. Takai Y., Kishimoto A., Iwasa Y., Kawahara Y., Mori T., and Nishizuka Y. Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids. J Biol Chem 254 (1979) 3692-3695
29. Tang W., and Shaikh Z.A. Renal cortical mitochondrial dysfunction upon cadmium metallothionein administration to Sprague-Dawley rats. J Toxicol Environ Health 63 (2001) 221-235
30. Thijssen S., Maringwa J., Faes C., Lambrichts I., and Van Kerkhove E. Chronic exposure of mice to environmentally relevant, low doses of cadmium leads to early renal damage, not predicted by blood or urine cadmium levels. Toxicology 229 (2007) 145-156
31. Wedeen R.P., and De Broe M.E. Heavy metals and the kidney. Oxford textbook of clinical nephrology (1998), Oxford University Press, Oxford 1175-1189
32. +-ATPase. J Biol Chem 20 (2004) 1-45
33. Yang X.F., Wang S.Y., Zhao R.C., Ao S.Q., Xu L.C., and Wang X.R. Changes in tissue metals after cadmium intoxication and intervention with chlorpromazine in male rats. Biomed Environ Sci 13 (2000) 19-25