Postmenopausal bleeding

Menopause International

Volumn 15, Issue 4, 2009, Pages 160-164

  Gale, Alison ^a   Dey, P ^a,b  

^a LANCASHIRE TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

Author keywords

endometrial biopsy; endometrial cancer; hysteroscopy; Postmenopausal bleeding; psychological morbidity

Indexed keywords

CLINICAL EXAMINATION; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; ENDOMETRIUM BIOPSY; ENDOMETRIUM CANCER; FEMALE; GYNECOLOGIC CANCER; HIGH RISK POPULATION; HUMAN; HYSTEROSCOPY; POSTMENOPAUSE; POSTMENOPAUSE BLEEDING; REVIEW; TRANSVAGINAL ECHOGRAPHY; VAGINA BLEEDING; WOMEN'S HEALTH;

AGED; ATTITUDE TO HEALTH; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; MIDDLE AGED; PATIENT ACCEPTANCE OF HEALTH CARE; POSTMENOPAUSE; RISK FACTORS; UTERINE HEMORRHAGE;

EID: 72149087940     PISSN: 17540453     EISSN: 17540461     Source Type: Journal    
DOI: 10.1258/mi.2009.009039     Document Type: Review

References (42)

1. Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007; 18: 581–92
2. Karim-Kos HE, de Vries E, Soerjomataram I, Lemmens V, Siesling S, Coebergh JWW. Recent trends of cancer in Europe: a combined approach of incidence, mortality and survival for 17 cancer sites since the 1990s. Eur J Cancer 2008; 44: 1345–89
3. Office for National Statistics. Cancer Statistic Registrations 2006. Registrations of Cancer Diagnosed in 2006, England. MB1 No. 37. OPSI London. See http://www.statistics.gov.uk/downloads/theme_health/MBI-37/MBI_37_2006.pdf ( last checked 29 April 2009)
4. Gondos A, Bray F, Brewster DH,, et al. Recent trends in cancer survival across Europe between 2000 and 2004: A model-based period analysis from 12 cancer registries. Eur J Cancer 2008; 44: 1463–75
5. Olsen AH, Parkin DH, Sasieni P. Cancer mortality in the United Kingdom: projections to 2025. Br J Cancer 2008; 99: 1549–55
6. World Cancer Research Fund/American Institute for Cancer Research. Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective. Washington, DC: AICR, 2007
7. Renehan AG, Tyson M, Eggar M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 2008; 371: 569–78
8. Park SL, Goodman MT, Zhang Z-F, Kolonel LN, Henderson BE, Setiawan VW. Body size, adult BMI gain and endometrial cancer risk: the multiethnic cohort. Int J Cancer 2009; July 7 (epub ahead of print). DOI: 10.1002/ijc.24718
9. Fader AN, Arriba LN, Frasure HE, von Gruenigen VE. Endometrial cancer and obesity: epidemiology, biomarkers, prevention and survivorship. Gynecol Oncol 2009; 114: 121–127
10. Reeves GK, Pirie K, Beral V, Green J, Spencer E, Bull D for the Million Women Study Collaborators. Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ 2007; 335: 1134
11. NHS Executive. National Cancer Guidance Steering Group. Guidance on Commissioning Cancer Services: Improving Outcomes in Gynaecological Cancers. See www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_4005385. ( last checked 29 April 2009)
12. Scottish Intercollegiate Guidelines Network. Investigation of Postmenopausal Bleeding. Guideline 61. See http://www.sign.ac.uk/pdf/sign61.pdf ( last checked 11 March 2009)
13. Ferrazzi E, Torri V, Trio D,, et al. Sonographic endometrial thickness: a useful test to predict atrophy in patients with postmenopausal bleeding. An Italian multicenter study. Ultrasound Obstet Gynecol 1996; 7: 315–21
14. Gredmark T, Kvint S, Havel G, Mattsson LA. Histopathological findings in women with postmenopausal bleeding. BJOG 1995; 102: 133–136
15. Scottish Intercollegiate Guidelines Network. Investigation of Postmenopausal Bleeding. Guideline 61. Supplementary Material. See http://www.sign.ac.uk/guidelines/published/support/guideline61/consultation.html ( last checked 29 April, 2009)
16. Parker C, Hippisley-Cox J, Coupland C, Vinogradova Y. Rectal and postmenopausal bleeding consultation and referral of patients with and without severe mental health problems. Br J Gen Pract 2007; 57: 371–376
17. Van Doorn HC, Opmeer BC, Jitze Duk M,, et al. The relation between age, time since menopause, and endometrial cancer in women with postmenopausal bleeding. Int J Gynaecol Cancer 2007; 17: 1118–23
18. National Institute for Clinical Excellence. Referral for Suspected Cancer. Clinical Guideline 27, 2005. See www.nice.org.uk/Guidance/CG27 ( last checked 25 February 2009)
19. Morrison J, Gillespie S, MacKenzie IZ. ‘Two week wait’ standards for suspected gynaecological malignancy. On target but missing the point? J Br Menopause Soc 2003; 9(4):170–2
20. Sulaiman S, Chong KW, Gaudoin M. One-stop postmenopausal bleeding clinics reduce patient waiting times and theatre costs. Scott Med J 2004; 49: 152–154
21. Mohamed H, Nair P. One-stop clinic for postmenopausal bleeding at a district general hospital: does it have a role? J Obstet Gynaecol 2003; 23: 182–184
22. Elliott J, Connor ME, Lashen H. The value of outpatient hysteroscopy in diagnosing endometrial pathology in postmenopausal women with and without hormone replacement therapy. Acta Obstet Gynecol Scand 2003; 82: 1112–9
23. Critchley HO, Warner P, Lee AJ,, et al. Evaluation of abnormal uterine bleeding: comparison of three outpatient procedures within cohorts defined by age and menopausal status. Health Technol Assess (Winchester, England) 2004; 8: ii–iv, 1–139
24. Alexopoulos ED, Simonis CD, Kidsley S, Fay TN. The value of outpatient hysteroscopy in the management of postmenopausal bleeding: a review of 862 cases. Gynaecol Endosc 2002; 9: 107–12
25. Sahla S, Okeahialam M, Jones S, O’Donovan PJ. Outpatient microhysteroscopy: why does it fail? Gynaecol Endosc 2002; 10: 167–71
26. Clark TJ, Barton PM, Coomarasamy A, Gupta JK, Khan KS. Investigating postmenopausal bleeding for endometrial cancer: cost-effectiveness of initial diagnostic strategies. BJOG 2006; 113: 502–10
27. American College of Obstetricians and Gynecologists. ACOG Committee Opinion No. 426: The role of transvaginal ultrasonography in the evaluation of postmenopausal bleeding. Obstet Gynecol 2009; 113: 462–464
28. Smith-Bindman R, Kerlikowske K, Feldstein VA,, et al. Endovaginal ultrasound to exclude endometrial abnormalities. JAMA 1998; 280: 1510–7
29. Gull B, Karlsson B, Milsom I, Granberg S. Can ultrasound replace dilation and curettage? A longitudinal evaluation of postmenopausal bleeding and transvaginal sonographic measurement of the endometrium as predictors of endometrial cancer. Am J Obstet Gynecol 2003; 188: 401–408
30. Rogerson L, Bates J, Weston M, Duffy S. A comparison of outpatient hysteroscopy with saline infusion hysterosonography. BJOG 2002; 109: 800–804
31. Oehler MK, MacKenzie I, Kehoe S, Rees MCP. Assessment of abnormal bleeding in menopausal women: an update. J Br Menopause Soc 2003; 9: 117–22
32. Munot S, Lane G. Modern management of postmenopausal bleeding. Trends Urol Gynaecol Sexual Health 2008; 13(5):20–4
33. Ackermann S, Renner SP, Fasching PA, Poehls U, Bender HG, Beckmann MW. Awareness of general and personal risk factors for uterine cancer among healthy women. Eur J Cancer Prev 2005; 14: 519–24
34. Soliman PT, Bassett LR, Wilson EB, Boyd-Rogers S, Schmeler KM. Limited public knowledge of obesity and endometrial cancer risk. What women know. Obstet Gynecol 2008; 112: 835–42
35. Coulson FR, Ypinazar VA, Margolis SA. Awareness of risks of overweight among rural Australians. Rural Remote Health 2006; 6: 514
36. Gale A, Tarling R, Martin-Hirsch P, Dey P. Psychological morbidity in women investigated for postmenopausal bleeding. Menopause Int 2008;14: 187 (abstract)
37. Gupta JK, Clark TJ, More S, Pattison H. Patient anxiety and experiences associated with an outpatient one-stop see and treat hysteroscopy clinic. Surg Endosc 2004; 18: 1099–104
38. Timmermans A, Opmeer BC, Veersema S, Mol BWJ. Patients’ preferences in the evaluation of postmenopausal bleeding. BJOG 2007; 114: 1146–9
39. Giorda G, Crivellari D, Veronesi A,, et al. Comparison of ultrasonography, hysteroscopy and biopsy in the diagnosis of endometrial lesions in postmenopausal tamoxifen treated patients. Acta Obstet Gynecol Scand 2002; 81: 975–80
40. Dijkhuizen FP, Brolman HA, Oddens BJ,, et al. Transvaginal ultrasonography and endometrial changes in postmenopausal breast cancer patients receiving tamoxifen. Mauritas 1996; 25: 45–50
41. Taponeco F, Curcio C, Fasciani A,, et al. Indication of hysteroscopy in tamoxifen treated breast cancer patients. J Exp Clin Cancer Res 2002; 21: 37–43
42. Wood NJ, Munot S, Sheridan E, Duffy SR. Does a ‘one-stop’ gynaecology screening clinic for women in hereditary nonpolyposis colorectal cancer families have an impact on their psychological morbidity and perception of health? Int J Gynecol Cancer 2008; 18: 279–84