Assessment of abnormal bleeding in menopausal women: An update

Menopause International

Volumn 9, Issue 3, 2003, Pages 117-122

  Oehler, Martin K ^a   Mackenzie, Ian ^b   Kehoe, Sean ^b   Rees, Margaret Cp ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Endometrial biopsy; endometrium; hysteroscopy; postmenopausal bleeding; transvaginal ultrasound

Indexed keywords

ESTRADIOL; PROGESTERONE; SEX HORMONE;

ASPIRATION; CLINICAL TRIAL; CURETTAGE; DIFFERENTIAL DIAGNOSIS; ENDOMETRIAL DISEASE; ENDOMETRIUM; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; FEMALE; FOLLOW UP; HEALTH CARE COST; HORMONE SUBSTITUTION; HUMAN; HYSTEROSCOPY; MEDICAL ASSESSMENT; MENOPAUSE; META ANALYSIS; OUTPATIENT CARE; POLYP; RECURRENT DISEASE; REVIEW; TRANSVAGINAL ECHOGRAPHY; UTERUS BIOPSY; UTERUS BLEEDING; UTERUS CAVITY; UTERUS PERFORATION; VAGINA BLEEDING;

BIOPSY; FEMALE; HUMANS; HYSTEROSCOPY; POSTMENOPAUSE; ULTRASONOGRAPHY; UTERINE HEMORRHAGE;

EID: 84990374908     PISSN: 17540453     EISSN: None     Source Type: Journal    
DOI: 10.1177/136218070300900310     Document Type: Review

References (35)

1. Ettinger B, Li DK, Klein R. Unexpected vaginal bleeding and associated gynecologic care in postmenopausal women using hormone replacement therapy: comparison of cyclic versus continuous combined schedules. Fertil Steril 1998; 69: 865–869.
2. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002; 288: 321–33.
3. Weiderpass E, Adami HO, Baron JA, et al. Risk of endometrial cancer following estrogen replacement with and without progestins. J Natl Cancer Inst. 1999; 9: 1131–1137.
4. Mortality statistics cause review of the Registrar General on deaths by cause, sex and age, in England and Wales, 2000: Series DH2 no 27. Office for National Statistics http://www.statistics.gov.uk (accessed April 2003).
5. Gredmark T, Kvint S, Havel G, Mattsson LA. Histopathological findings in women with postmenopausal bleeding. Br J Obstet Gynaecol 1995; 102: 133–136.
6. Saslow D, Runowicz CD, Solomon D, et al. American Cancer Society guideline for the early detection of cervical neoplasia and cancer. CA Cancer J Clin 2002; 52: 342–362.
7. Weiderpass E, Persson I, Adami HO, et al. Body size in different periods of life, diabetes mellitus, hypertension, and risk of postmenopausal endometrial cancer (Sweden). Cancer Causes Control 2000; 11: 185–192.
8. Bergman L, Beelen M, Gallee M, et al. Risk and prognosis of endometrial cancer after tamoxifen for breast cancer. Lancet 2000; 356: 881–887.
9. Gupta JK, Chien PF, Voit D, Clark TJ, Khan KS. Ultrasonographic endometrial thickness for diagnosing endometrial pathology in women with postmenopausal bleeding: a meta-analysis. Acta Obstet Gynecol Scand 2002; 81: 799–816.
10. Medverd JR, Dubinsky TJ. Cost analysis model: US versus endometrial biopsy in evaluation of peri- and postmenopausal abnormal vaginal bleeding. Radiology 2002; 222: 619–627.
11. Smith-Bindman R Kerlikowske K Feldstein VA, et al. Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities. JAMA 1998; 280: 1510–1517.
12. Gull B, Carlsson S, Karlsson B, et al. Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding: is it always necessary to perform an endometrial biopsy? Am J Obstet Gynecol 2000; 182: 509–15.
13. Tsuda H, Kawabata M, Yamamoto K, et al. Prospective study to compare endometrial cytology and transvaginal ultrasonography for identification of endometrial malignancies. Gynecol Oncol 1997; 65: 383–386.
14. Granberg S, Ylostalo P, Wikland M, Karlsson B. Endometrial sonographic and histologic findings in women with and without hormonal replacement therapy suffering from postmenopausal bleeding. Maturitas 1997; 27: 35–40.
15. Archer DF, Lobo RA, Land HF, Pickar JH. A comparative study of transvaginal uterine ultrasound and endometrial biopsy for evaluating the endometrium of postmenopausal women taking hormone replacement therapy. Menopause 1999; 6: 201–208.
16. Deckardt R, Lueken RP, Gallinat A, et al. Comparison of transvaginal ultrasound, hysteroscopy, and dilatation and curettage in the diagnosis of abnormal vaginal bleeding and intrauterine pathology in perimenopausal and postmenopausal women. J Am Assoc Gynecol Laparosc 2002; 9: 277–282.
17. Affinito P, Palomba S, Sammartino A, et al. Ultrasonographic endometrial monitoring during continuous-sequential hormonal replacement therapy regimen in postmenopausal women. Maturitas 2001; 39: 239–244.
18. Epstein E, Ramirez A, Skoog L, et al. Transvaginal sonography, saline contrast sonohysterography and hysteroscopy for the investigation of women with postmenopausal bleeding and endometrium >5 mm. Ultrasound Obstet Gynecol 2001; 18: 157–162.
19. Ballester MJ, Girones R, Torres JV, et al. Diagnosis of endometrial carcinoma: predictive value of transvaginal color Doppler. J Gynecol Surg 1994; 10: 173–183.
20. Sheth S, Hamper UM, McCollum ME, et al. Endometrial blood flow analysis in postmenopausal women: can it help differentiate benign from malignant causes of endometrial thickening? Radiology 1995; 195: 661–665.
21. Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia. A long-term study of “untreated” hyperplasia in 170 patients. Cancer 1985; 56: 403–412.
22. Epstein E, Ramirez A, Skoog L, Valentin L. Dilatation and curettage fails to detect most focal lesions in the uterine cavity in women with postmenopausal bleeding. Acta Obstet Gynecol Scand 2001; 80: 1131–1136.
23. Bettocchi S, Ceci O, Vicino M, et al. Diagnostic approach of dilatation and curettage. Fertil Steril 2001; 75: 803–805.
24. Good AE. Diagnostic options for assessment of postmenopausal bleeding. Mayo Clin Proc 1997; 72: 345–349.
25. Guido RS, Kanbour-Shakir A Rulin MC Christopherson WA. Pipelle endometrial sampling: sensitivity in the detection of endometrial cancer. J Reprod Med 1995; 40: 553–555.
26. Manganiello PD, Burrows LJ, Dain BJ, Gonzalez J. Vabra aspirator and pipelle endometrial suction curette. A comparison. J Reprod Med 1998; 43: 889–892.
27. Dijkhuizen FP, Mol BW, Brolmann HA, Heintz AP. The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia: a meta-analysis. Cancer 2000; 89: 1765–1772.
28. Feldman S, Shapter A, Welch WR, et al. Two year follow-up of 263 patients with post/perimenopausal women vaginal bleeding and negative initial biopsy. Gynecol Oncol 1994; 55: 56–59.
29. Gull B, Karlsson B, Milsom I, Granberg S. Can ultrasound replace dilation and curettage? A longitudinal evaluation of postmenopausal bleeding and transvaginal sonographic measurement of the endometrium as predictors of endometrial cancer. Am J Obstet Gynecol 2003; 188: 401–408.
30. Mortakis AE, Mavrelos K. Transvaginal ultrasonography and hysteroscopy in the diagnosis of endometrial abnormalities. J Am Assoc Gynecol Laparosc 1997; 4: 449–452.
31. Torrejon R, Fernandez-Alba JJ Carnicer I, et al. The value of hysteroscopic exploration for abnormal uterine bleeding. J Am Assoc Gynecol Laparosc 1997; 4: 453–456.
32. Ben-Yehuda OM Kim YB Leuchter RS. Does hysteroscopy improve upon the sensitivity of dilatation of curettage in the diagnosis of endometrial hyperplasia or carcinoma? Gynecol Oncol 1998; 68: 4–7.
33. Tahir MM, Bigrigg MA, Browning JJ, et al. A randomised controlled trial comparing transvaginal ultrasound, outpatient hysteroscopy and endometrial biopsy with inpatient hysteroscopy and curettage. Br J Obstet Gynaecol 1999; 106: 1259–1264.
34. Clark TJ, Voit D, Gupta JK, et al. Accuracy of hysteroscopy in the diagnosis of endometrial cancer and hyperplasia: a systematic quantitative review. JAMA 2002; 288: 1610–1621.
35. Arikan G, Reich O, Weiss U, et al. Are endometrial carcinoma cells disseminated at hysteroscopy functionally viable? Gynecol Oncol 2001; 83: 221–226.