Oxo-bridged isomers of aza-trishomocubane sigma (σ) receptor ligands: Synthesis, in vitro binding, and molecular modeling

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 1, 2010, Pages 145-148

  Banister, Samuel D ^a   Moussa, Iman A ^a   Jordan, Meredith J T ^a   Coster, Mark J ^b   Kassiou, Michael ^a,c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b GRIFFITH UNIVERSITY   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Drug design; Hemiaminal; Molecular modeling; Sigma receptor; Structure activity; Trishomocubane

Indexed keywords

ADRENERGIC RECEPTOR; ADRENERGIC RECEPTOR ALPHA2C; AZA TRISHOMOCUBANE SIGMA RECEPTOR LIGAND; DOPAMINE TRANSPORTER; OPIATE RECEPTOR; PHENETHYL ALCOHOL; PHENETHYL DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOASSAY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ISOMER; MOLECULAR MODEL;

AZA COMPOUNDS; DRUG DESIGN; ISOMERISM; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, SIGMA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72049117883     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.019     Document Type: Article

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