Conservative surgery with and without radiotherapy in elderly patients with early-stage breast cancer: A prospective randomised multicentre trial

Breast

Volumn 18, Issue 6, 2009, Pages 373-377

  Tinterri, C ^a   Gatzemeier, W ^a   Zanini, V ^b   Regolo, L ^b   Pedrazzoli, C ^g   Rondini, E ^g   Amanti, C ^h   Gentile, G ^k   Taffurelli, M ^j   Fenaroli, P ^e   Tondini, C ^e   Sacchetto, G ^d   Sismondi, P ^l   Murgo, R ⁱ   Orlandi, M ^m   Cianchetti, E ^f   Andreoli, C ^c  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^b IRCCS   (Italy)

^c Senology Division   (Italy)

^d General Hospital Alba   (Italy)

^e General Hospital Bergamo   (Italy)

^f General Hospital Ortona   (Italy)

^g S MARIA NUOVA HOSPITAL   (Italy)

^h SAPIENZA UNIVERSITY OF ROME   (Italy)

ⁱ CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^j UNIVERSITY OF BOLOGNA   (Italy)

^k SANTA MARIA DELLA MISERICORDIA UNIVERSITY HOSPITAL   (Italy)

^l Cancer Research Centre Torino   (Italy)

^m General Hospital Cirié   (Italy)

more..

Author keywords

Breast conserving therapy; Clinical trial; Radiation treatment

Indexed keywords

AGED; ARTICLE; AXILLARY LYMPH NODE; BREAST CANCER; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RELAPSE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DISTANT METASTASIS; FEMALE; FOLLOW UP; GERIATRIC PATIENT; HUMAN; LYMPH NODE DISSECTION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OVERALL SURVIVAL; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEGMENTAL MASTECTOMY; SENTINEL LYMPH NODE BIOPSY;

EID: 72049113068     PISSN: 09609776     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.breast.2009.09.013     Document Type: Article

References (22)

1. NIH Consensus Conference. Treatment of early stage breast cancer. JAMA 265 3 (1991 Jan 16V) 391-395
2. Fisher B., Anderson S., Redmond C.K., Wolmark N., Wickerham D.L., and Cronin W.M. Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med 333 (1995) 1456-1461
3. Veronesi U., Luini A., Galimberti V., and Zurrida S. Conservation approaches for the management of stage I/II carcinoma of the breast: Milan Cancer Institute Trials. World J Surg 18 (1994) 70-75
4. Clark R.M., Whelan T., Levine M., Roberts R., Willan A., McCulloch P., et al. Randomized clinical trial of irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. J Natl Cancer Inst 88 (1996) 1659-1664
5. Forrest A.P., Stewart H.J., Evering D., Prescott R.J., McArdle C.S., Harnett A.N., et al. Randomized controlled trial of conservation therapy for breast cancer: 6 year analysis of the Scottish trial. Lancet 348 (1996) 708-713
6. Renton S.C., Gazet J.C., Ford H.T., Crbishley C., and Sutcliff R. The importance of the margin in conservative surgery for breast cancer. Eur J Surg Oncol 22 (1996) 17-22
7. Liljegren G., Holmberg L., Bergh J., Lindgren A., Tabár L., Nordgren H., et al. 10-Year results after sector resection with or without postoperative radiotherapy for stage I breast cancer: a randomized trial. J Clin Oncol 17 (1999) 2326-2333
8. Veronesi U., Saccozzi R., Del Vecchio M., Banfi A., Clemente C., De Lena M., et al. Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med 305 1 (1981 Jul 2) 6-11
9. Veronesi U., Marubini E., Mariani L., Galimberti V., Luini A., Veronesi P., et al. Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial. Ann Oncol 12 (2001) 997-1003
10. Standard di Riferimento dell'irradiazione del cancro della mammella in stadio iniziale. AIRO (1997)
11. Bull A.A., Meyerowitz B.E., Hart S., Mosconi P., Apolone G., and Liberati A. Quality of life in women with breast cancer. Breast Cancer Res Treat 54 (1999) 47-57
12. Athas W.F., Adams-Cameron M., Hunt W.C., Amir-Fazli A., and Key C.R. Travel distance to radiation therapy and receipt of radiotherapy following breast conserving surgery. J Natl Cancer Inst 92 (2000) 269-271
13. Anderson M. Risk of second primary cancer among patients with early operable breast cancer registered or randomised in Danish Breast Cancer cooperative Group (DBCG) protocols of the 77, 82 and 89 programmes during 1977-2001. Acta Oncol 47 (2008) 755-764
14. Patel R.R., Christensen M.E., Hodge C.W., Adkison J.B., and Das P.K. Clinical outcome analysis in "high-risk" versus "low-risk" patients eligible for national surgical adjuvant breast and bowel B-39/radiation therapy oncology group 0413 trial: five-year results. Int J Radiat Oncol Biol Phys 70 4 (2008 Mar 15) 970-973
15. Vicini F.A., and McCarthy N.J. Three-year analysis of treatment efficacy, cosmesis, and toxicity by the American Society of Breast Surgeons MammoSite Breast Brachytherapy Registry Trial in patients treated with accelerated partial breast irradiation (APBI). Cancer 15 112 (2008) 758-766
16. Passage K.J. Critical review of the management of early-stage breast cancer in elderly women. Internal Med J 37 (2007) 181-189
17. Albrand G. Early breast cancer in the elderly: assessment and management considerations. Drugs Aging 25 (2008) 35-45
18. Crivellari D., Aapro M., Leonard R., von Minckwitz G., Brain E., Goldhirsch A., et al. Breast cancer in the elderly. J Clin Oncol 25 14 (2007 May 10) 1882-1890
19. START Trialists' Group, Bentzen S.M., Agrawal R.K., Aird E.G., Barrett J.M., Barrett-Lee P.J., Bliss J.M., et al. The UK standardisation of breast radiotherapy (START) trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet Oncol 9 (2008) 331-341
20. Lövey K., Fodor J., Major T., Szabó E., Orosz Z., Sulyok Z., et al. Fat necrosis after partial-breast irradiation with brachytherapy or electron irradiation versus standard whole-breast radiotherapy - 4-year results of a randomized trial. Int J Radiat Oncol Biol Phys 69 3 (2007 Nov 1) 694-702
21. Pötter R., Gnant M., Kwasny W., Tausch C., Handl-Zeller L., Pakisch B., et al. Lumpectomy plus tamoxifen or anastrozole with or without whole breast irradiation in women with favorable early breast cancer. Int J Radiat Oncol Biol Phys 68 2 (2007 Jun 1) 334-340
22. PRIME trial. Health Technol Assess 11 31 (2007 Aug) 1-149 iii-iv