A Murine Model for the Study of Molecular Pathogenesis of Radiation Proctitis

International Journal of Radiation Oncology Biology Physics

Volumn 76, Issue 1, 2010, Pages 242-250

  Symon, Zvi ^a   Goldshmidt, Yifat ^a   Picard, Orit ^a   Yavzori, Miri ^a   Ben Horin, Shomron ^a   Alezra, Dror ^a   Barshack, Iris ^a   Chowers, Yehuda ^b  

^a SHEBA MEDICAL CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Chronic radiation proctitis; Murine model

Indexed keywords

AREA UNDER THE CURVES; BALB/C MICE; BOWEL OBSTRUCTION; BRACHYTHERAPY; C57BL/6 MICE; CYTOKINES; DOSE-DEPENDENT; INTERLEUKIN-1; INTERVENTIONAL; MOLECULAR PATHOGENESIS; MOUSE MODELS; MRNA EXPRESSION; MRNA EXPRESSION LEVEL; MRNA LEVEL; MURINE MODEL; PROINFLAMMATORY CYTOKINES; RADIATION DOSE; RADIATION INJURY; RADIATION-INDUCED; REAL-TIME PCR; RECEIVER OPERATING CHARACTERISTIC CURVES; TISSUE EXPRESSION; TRANSFORMING GROWTH FACTORS; TUMOR NECROSIS FACTORS;

INTERLOCKING SIGNALS;

RADIATION;

INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRACHYTHERAPY; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; INFLAMMATION; IRRADIATION; MORTALITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROCTITIS; RADIATION DOSE; RECTUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; WEIGHT REDUCTION;

ANIMALS; BIOLOGICAL MARKERS; BRACHYTHERAPY; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; INTERLEUKIN-1BETA; INTERLEUKIN-6; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PROCTITIS; RADIATION INJURIES, EXPERIMENTAL; RECTUM; RNA, MESSENGER; ROC CURVE; SPECIES SPECIFICITY; TIME FACTORS; TRANSFORMING GROWTH FACTORS; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT LOSS;

EID: 72049112820     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.07.1736     Document Type: Article

References (30)

1. Hayne D., Vaizey C.J., and Boulos P.B. Anorectal injury following pelvic radiotherapy. Br J Surg 88 (2001) 1037-1048
2. Cotti G., Seid V., Araujo S., et al. Conservative therapies for hemorrhagic radiation proctitis: a review. Rev Hosp Clin Fac Med Sao Paulo 58 (2003) 284-292
3. Andreyev J. Gastrointestinal complications of pelvic radiotherapy: are they of any importance?. Gut 54 (2005) 1051-1054
4. Simone N.L., Menard C., Soule B.P., et al. Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score. Int J Radiat Oncol Biol Phys 70 (2008) 90-95
5. Hovdenak N., Sorbye H., and Dahl O. Sucralfate does not ameliorate acute radiation proctitis: Randomised study and meta-analysis. Clin Oncol (R Coll Radiol) 17 (2005) 485-491
6. Sanguineti G., Franzone P., Marcenaro M., et al. Sucralfate versus mesalazine versus hydrocortisone in the prevention of acute radiation proctitis during conformal radiotherapy for prostate carcinoma. A randomized study. Strahlenther Onkol 179 (2003) 464-470
7. Gul Y.A., Prasannan S., Jabar F.M., et al. Pharmacotherapy for chronic hemorrhagic radiation proctitis. World J Surg 26 (2002) 1499-1502
8. Kochhar R., Sriram P.V., Sharma S.C., et al. Natural history of late radiation proctosigmoiditis treated with topical sucralfate suspension. Dig Dis Sci 44 (1999) 973-978
9. O'Brien P.C., Franklin C.I., Dear K.B., et al. A phase III double-blind randomised study of rectal sucralfate suspension in the prevention of acute radiation proctitis. Radiother Oncol 45 (1997) 117-123
10. Kochhar R., Patel F., Dhar A., et al. Radiation-induced proctosigmoiditis. Prospective, randomized, double-blind controlled trial of oral sulfasalazine plus rectal steroids versus rectal sucralfate. Dig Dis Sci 36 (1991) 103-107
11. Clarke R.E., Tenorio L.M., Hussey J.R., et al. Hyperbaric oxygen treatment of chronic refractory radiation proctitis: a randomized and controlled double-blind crossover trial with long-term follow-up. Int J Radiat Oncol Biol Phys 72 (2008) 134-143
12. Tagkalidis P.P., and Tjandra J.J. Chronic radiation proctitis. ANZ J Surg 71 (2001) 230-237
13. Denton A.S., Andreyev H.J., Forbes A., et al. Systematic review for non-surgical interventions for the management of late radiation proctitis. Br J Cancer 87 (2002) 134-143
14. Rubinstein E., Ibsen T., Rasmussen R.B., et al. Formalin treatment of radiation-induced hemorrhagic proctitis. Am J Gastroenterol 81 (1986) 44-45
15. Armour E.P., White J.R., Armin A., et al. Pulsed low dose rate brachytherapy in a rat model: Dependence of late rectal injury on radiation pulse size. Int J Radiat Oncol Biol Phys 38 (1997) 825-834
16. Johannessen H.O., Dale E., Hellebust T.P., et al. Modeling volume effects of experimental brachytherapy in the rat rectum: Uncovering the limitations of a radiobiologic concept. Int J Radiat Oncol Biol Phys 53 (2002) 1014-1022
17. Black W.C., Gomez L.S., Yuhas J.M., et al. Quantitation of the late effects of X-radiation on the large intestine. Cancer 45 (1980) 444-451
18. White J.R., Armour E.P., Armin A.R., et al. Reproducible rat model for comparing late rectal toxicity from different brachytherapy techniques. Int J Radiat Oncol Biol Phys 37 (1997) 1155-1161
19. Jensen M.H., Sauer T., Devik F., et al. Late changes following single dose roentgen irradiation of rat small intestine. Acta Radiol Oncol 22 (1983) 299-303
20. O'Brien P.C. Radiation injury of the rectum. Radiother Oncol 60 (2001) 1-14
21. Skwarchuk M.W., and Travis E.L. Changes in histology and fibrogenic cytokines in irradiated colorectum of two murine strains. Int J Radiat Oncol Biol Phys 42 (1998) 169-178
22. Skwarchuk M.W., and Travis E.L. Murine strain differences in the volume effect and incidence of radiation-induced colorectal obstruction. Int J Radiat Oncol Biol Phys 41 (1998) 889-895
23. Trott K.R., Tamou S., Sassy T., et al. The effect of irradiated volume on the chronic radiation damage of the rat large bowel. Strahlenther Onkol 171 (1995) 326-331
24. Tamou S., and Trott K.R. The effects of local X-irradiation on the distensibility of the rectum in rats. Br J Radiol 68 (1995) 64-69
25. Langberg C.W., Sauer T., Reitan J.B., et al. Relationship between intestinal fibrosis and histopathologic and morphometric changes in consequential and late radiation enteropathy. Acta Oncol 35 (1996) 81-87
26. Followill D.S., Kester D., and Travis E.L. Histological changes in mouse colon after single- and split-dose irradiation. Radiat Res 136 (1993) 280-288
27. Linard C., Ropenga A., Vozenin-Brotons M.C., et al. Abdominal irradiation increases inflammatory cytokine expression and activates NF-kappaB in rat ileal muscularis layer. Am J Physiol Gastrointest Liver Physiol 285 (2003) G556-565
28. Nagtegaal I.D., Gaspar C.G., Peltenburg L.T., et al. Radiation induces different changes in expression profiles of normal rectal tissue compared with rectal carcinoma. Virchows Arch 446 (2005) 127-135
29. Indaram A.V., Visvalingam V., Locke M., et al. Mucosal cytokine production in radiation-induced proctosigmoiditis compared with inflammatory bowel disease. Am J Gastroenterol 95 (2000) 1221-1225
30. Withers H.R., and Mason K.A. The kinetics of recovery in irradiated colonic mucosa of the mouse. Cancer 34 Suppl (1974) 896-903