Modeling volume effects of experimental brachytherapy in the rat rectum: Uncovering the limitations of a radiobiologic concept

International Journal of Radiation Oncology Biology Physics

Volumn 53, Issue 4, 2002, Pages 1014-1022

  Johannessen, Hans Olaf ^a   Dale, Einar ^a   Hellebust, Taran P ^a   Olsen, Dag R ^a   Nesland, Jahn M ^a   Giercksky, Karl Erik ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

Brachytherapy; Experimental radiation injuries; Normal tissue complication probabilities; Rectum; Volume dependence

Indexed keywords

DOSIMETRY; ONCOLOGY; POLYSTYRENES; TISSUE;

RECTAL STENOSIS;

RADIATION;

IRIDIUM 192; LEAD; POLYSTYRENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOPHYSICS; BRACHYTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DOSIMETRY; EXPERIMENTAL MODEL; EXPERIMENTAL RAT; INCIDENCE; LIVER; MALE; NONHUMAN; PARAMETER; PRIORITY JOURNAL; PROBABILITY; RADIATION APPLICATOR; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIATION DOSE FRACTIONATION; RADIATION FIELD; RADIATION INJURY; RADIATION RESPONSE; RADIATION SHIELD; RADIOBIOLOGY; RAT; RECTUM; RECTUM INJURY; STENOSIS; TISSUE REACTION; TISSUE REPAIR; ULCER; X IRRADIATION;

ANIMALS; BIOPHYSICS; BODY WEIGHT; BRACHYTHERAPY; DOSE-RESPONSE RELATIONSHIP, RADIATION; IRIDIUM RADIOISOTOPES; LIVER; MALE; MODELS, THEORETICAL; RADIOMETRY; RATS; RATS, INBRED F344; RECTAL NEOPLASMS; RECTUM; X-RAYS;

EID: 0037100051     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(02)02835-3     Document Type: Article

References (54)

1. The efficacy of lead shielding in megavoltage radiotherapy
2. Lateral rectal shielding reduces late rectal morbidity following high dose three-dimensional conformal radiation therapy for clinically localized prostate cancer: Further evidence for a significant dose effect
3. Late rectal toxicity after conformal radiotherapy of prostate cancer (I): Multivariate analysis and dose-response
4. Measurement of dose distribution around Fletcher-Suit-Delcos colpostats using a Therados radiation field analyzer (RFA-3)
5. Evaluation of rectal shielding in a Henschke System Applicator
6. Factors affecting local control and survival after treatment of carcinoma of the rectum by endocavitary radiation: A retrospective study of 97 cases
7. Technical hints for high dose rate interstitial tongue brachytherapy
8. Conformal episcleral plaque therapy
9. Complication probability as assessed from dose volume histograms
10. Calculation of complication probability factors for non-uniform normal tissue irradiation: The effective volume method
11. Fitting of normal tissue tolerance data to an analytic function
12. Normal tissue complication probabilities correlated with late effects in the rectum after prostate conformal therapy
13. Optimization of radiation therapy: Integral-response of a model biological system
14. Treatment volume and tissue tolerance
15. Tumor and normal tissue response to fractionated non uniform dose delivery
16. Analysis of clinical complication data for radiation hepatitis using a parallel architecture model
17. Tolerance of normal tissue to therapeutic irradiation
18. Estimation of the incidence of late bladder and rectum complications after high-dose (70-78 Gy) conformal radiotherapy for prostate cancer, using dose volume histograms
19. Incidence of and factors related to late complications in conformal and conventional radiation treatment of cancer of the prostate
20. Modeling normal tissue complication probability from repetitive computed tomography scans during fractionated high-dose-rate brachytherapy and external beam radiotherapy of the uterine cervix
21. Late rectal bleeding following combined X-ray and proton high dose irradiation for patients with stages T3-T4 prostate carcinoma
22. New wine in an old bottle? Dose escalation under dose-volume constraints: A model of conformal therapy of the prostate
23. Late radiation damage in prostate cancer patients treated by high dose external radiotherapy in relation to rectal dose
24. Complications from radiotherapy dose escalation in prostate cancer: Preliminary results of a randomized trial
25. A method of analysing rectal surface area irradiated and rectal complication in prostate conformal radiotherapy
26. Endocavitary irradiation in the conservative treatment of adenocarcinoma of the low rectum
27. The role of radiotherapy in the conservative treatment of rectal carcinoma - The Lyon experience
28. Chronic radiation sequelae in the rat rectum following intracavitary irradiation with different doses
29. Development of an experimental model for high dose rate endocavitary irradiation of the rat rectum
30. Influence of brachytherapy dosage and shielding on body weight and the development of radiation proctitis in the rat
31. High dose rate endocavitary irradiation of the rat rectum with an unshielded applicator: Early and late reactions after single dose and hypofractionation
32. Ferrous sulphate gels for determination of absorbed dose distributions using MRI technique: Basic studies
33. Chemical dosimetry
34. MR imaging of absorbed dose distributions for radiotherapy using ferrous sulphate gels
35. Quantitation of the late effects of x-radiation on the large intestine
36. 241Am applicator for continuous low dose rate irradiation of the rat rectum
37. Treatment-time-dependence models of early and delayed radiation injury in rat small intestine
38. Alpha/beta value and importance of dose per fraction for late rectal and recto-sigmoid complications
39. Chronic radiation damage in the rat rectum: An analysis of the influence of fractionation, time and volume
40. Normal tissue complication probabilities: How well do the models work?
41. The volume effect in radiotherapy - Its biological significance
42. Volume effects in radiobiology as applied to radiotherapy
43. Effect of irradiated volume on lung damage in pigs
44. Endoscopic scoring of late rectal mucosal damage after conformal radiotherapy for prostatic carcinoma
45. Effect of age on radiation-induced early changes of rat rectum. A histological time sequence
46. The effect of irradiated volume on the chronic radiation damage of the rat large bowel
47. Regulation of intestinal regeneration: New insights
48. Mechanisms and modulation of intestinal epithelial repair
49. The radiobiological basis for low dose-rate radiotherapy
50. RBE values for colo-rectal injury after caesium 137 gamma-ray and neutron irradiation. I. Single doses
51. Present status of radiation therapy in the conservative management of rectal cancer
52. The status of radiation therapy in the management of carcinoma of the rectum
53. Endoluminal radiotherapy for rectal tumors