Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples

Psychiatry Research

Volumn 175, Issue 1-2, 2010, Pages 176-178

  Hirata, Yuko ^a,b   Souza, Renan P ^a,b   Lieberman, Jeffrey A ^c   Meltzer, Herbert Y ^d   Kennedy, James L ^a,b  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d VANDERBILT UNIVERSITY   (United States)

Author keywords

5 HT4; Schizophrenia; Serotonin receptor 4

Indexed keywords

SEROTONIN 4 RECEPTOR;

ADULT; ARTICLE; CASE CONTROL STUDY; CAUCASIAN; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECEPTOR GENE; RISK FACTOR; SCHIZOPHRENIA;

ADULT; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; POLYMORPHISM, GENETIC; RECEPTORS, SEROTONIN, 5-HT4; SCHIZOPHRENIA;

EID: 72049101243     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2009.08.005     Document Type: Article

References (15)

1. Altshuler D., Kruglyak L., and Lander E. Genetic polymorphisms and disease. New England Journal of Medicine 338 (1998) 1626
2. Blondel O., Gastineau M., Dahmoune Y., Langlois M., and Fischmeister R. Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. Journal of Neurochemistry 70 (1998) 2252-2261
3. Elvevag B., and Goldberg T.E. Cognitive impairment in schizophrenia is the core of the disorder. Critical Reviews in Neurobiology 14 (2000) 1-21
4. Freedman R. Schizophrenia. New England Journal of Medicine 349 (2003) 1738-1749
5. Hodgkinson C.A., Yuan Q., Xu K., Shen P.H., Heinz E., Lobos E.A., Binder E.B., Cubells J., Ehlers C.L., Gelernter J., Mann J., Riley B., Roy A., Tabakoff B., Todd R.D., Zhou Z., and Goldman D. Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol and Alcoholism 43 (2008) 505-515
6. Ji X., Takahashi N., Saito S., Ishihara R., Maeno N., Inada T., and Ozaki N. Relationship between three serotonin receptor subtypes (HTR3A, HTR2A and HTR4) and treatment-resistant schizophrenia in the Japanese population. Neuroscience Letters 435 (2008) 95-98
7. Medhurst A.D., Lezoualc'h F., Fischmeister R., Middlemiss D.N., and Sanger G.J. Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR. Brain Research Molecular Brain Research 90 (2001) 125-134
8. Meneses A. 5-HT system and cognition. Neuroscience & Biobehavioral Reviews 23 (1999) 1111-1125
9. Ohtsuki T., Ishiguro H., Detera-Wadleigh S.D., Toyota T., Shimizu H., Yamada K., Yoshitsugu K., Hattori E., Yoshikawa T., and Arinami T. Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees. Molecular Psychiatry 7 (2002) 954-961
10. Reis H.J., Rosa D.V., Guimaraes M.M., Souza B.R., Barros A.G., Pimenta F.J., Souza R.P., Torres K.C., and Romano-Silva M.A. Is DARPP-32 a potential therapeutic target?. Expert Opinion in Therapeutic Targets 11 (2007) 1649-1661
11. Rosa D.V., Souza R.P., Souza B.R., Guimaraes M.M., Carneiro D.S., Valvassori S.S., Gomez M.V., Quevedo J., and Romano-Silva M.A. DARPP-32 expression in rat brain after an inhibitory avoidance task. Neurochemical Research 33 (2008) 2257-2262
12. Souza R.P., Romano-Silva M.A., Lieberman J.A., Meltzer H.Y., Wong A.H., and Kennedy J.L. Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response. Psychopharmacology (Berl) 200 (2008) 177-186
13. Sullivan P.F. Spurious genetic associations. Biological Psychiatry 61 (2007) 1121-1126
14. Suzuki T., Iwata N., Kitamura Y., Kitajima T., Yamanouchi Y., Ikeda M., Nishiyama T., Kamatani N., and Ozaki N. Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia. American Journal of Medical Genetics B Neuropsychiatric Genetics 121B (2003) 7-13
15. Svenningsson P., Tzavara E.T., Liu F., Fienberg A.A., Nomikos G.G., and Greengard P. DARPP-32 mediates serotonergic neurotransmission in the forebrain. Proceedings of the National Academy of Sciences USA 99 (2002) 3188-3193